Recombinant Human ASAH1 protein, MYC/DDK-tagged
Cat.No. : | ASAH1-2682H |
Product Overview : | Recombinant Human ASAH1, transcript variant 2, fused with MYC/DDK tag at C-terminal was expressed in HEK293. |
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Description : | This gene encodes a heterodimeric protein consisting of a nonglycosylated alpha subunit and a glycosylated beta subunit that is cleaved to the mature enzyme posttranslationally. The encoded protein catalyzes the synthesis and degradation of ceramide into sphingosine and fatty acid. Mutations in this gene have been associated with a lysosomal storage disorder known as Farber disease. Multiple transcript variants encoding several distinct isoforms have been identified for this gene. |
Source : | HEK293 |
Species : | Human |
Tag : | MYC/DDK |
Form : | 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol. |
Molecular Mass : | 46.3 kDa |
Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining |
Concentration : | >50 ug/mL as determined by microplate BCA method |
Gene Name : | ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1 [ Homo sapiens ] |
Official Symbol : | ASAH1 |
Synonyms : | ASAH1; N-acylsphingosine amidohydrolase (acid ceramidase) 1; ASAH, N acylsphingosine amidohydrolase (acid ceramidase); acid ceramidase; AC; FLJ21558; PHP32; acid CDase; acylsphingosine deacylase; putative 32 kDa heart protein; PHP; ASAH; ACDase; FLJ22079; |
Gene ID : | 427 |
mRNA Refseq : | NM_004315 |
Protein Refseq : | NP_004306 |
MIM : | 613468 |
UniProt ID : | Q13510 |
Chromosome Location : | 8p22 |
Pathway : | Ceramide signaling pathway, organism-specific biosystem; Glycosphingolipid metabolism, organism-specific biosystem; Lysosome, organism-specific biosystem; Lysosome, conserved biosystem; Metabolic pathways, organism-specific biosystem; Metabolism, organism-specific biosystem; Metabolism of lipids and lipoproteins, organism-specific biosystem; |
Function : | catalytic activity; ceramidase activity; hydrolase activity; |
Products Types
◆ Recombinant Protein | ||
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Asah1-655M | Recombinant Mouse Asah1 Protein, MYC/DDK-tagged | +Inquiry |
ASAH1-1134H | Recombinant Human ASAH1 Protein, His-SUMO-tagged | +Inquiry |
ASAH1-2093M | Recombinant Mouse ASAH1 Protein (19-141 aa), His-GST-Myc-tagged | +Inquiry |
ASAH1-524H | Recombinant Human ASAH1 Protein, His-tagged | +Inquiry |
◆ Lysates | ||
ASAH1-8670HCL | Recombinant Human ASAH1 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (8)
Ask a questionGiven the involvement of ASAH1 in various diseases, including cancer, modulating its activity or developing ASAH1 inhibitors holds promise as potential therapeutic strategies.
Yes, alterations in ASAH1 gene expression or activity can impact cellular differentiation processes, as ceramide metabolism is crucial for normal development and tissue homeostasis.
Yes, mutations or deficiencies in the ASAH1 gene are associated with Farber disease, a rare inherited disorder characterized by the accumulation of ceramide in tissues throughout the body.
ASAH1 deficiency, as seen in Farber disease, is a genetic disorder. Prevention involves genetic counseling for at-risk individuals and prenatal testing during pregnancy.
Currently, ASAH1 deficiency is not included in routine newborn screening panels. However, advancements in testing methods may lead to its inclusion in the future.
Besides its role in ceramide metabolism, the ASAH1 protein can affect immune response, inflammation, and cellular stress responses.
Dysfunction of the ASAH1 protein impairs the breakdown of ceramide, leading to its accumulation in various tissues and disrupting cellular homeostasis.
Yes, the ASAH1 protein can modulate signaling pathways like the sphingosine-1-phosphate pathway, which influences various cellular processes such as migration, inflammation, and angiogenesis.
Customer Reviews (3)
Write a reviewSuch dedicated support makes me feel confident in my choice of using the ASAH1 protein for my experiments.
The manufacturer's commitment to excellence is truly commendable, especially when it comes to their outstanding technical support.
The ASAH1 Protein is a protein of exceptional quality that surpasses my expectations and fulfills all my experimental requirements.
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