Recombinant Human ASCC2 Protein, Myc/DDK-tagged, C13 and N15-labeled

• Cat.No.: ASCC2-5530H
• Product Overview: ASCC2 MS Standard C13 and N15-labeled recombinant protein (NP_115580) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.

Specification

• Description: Enhances NF-kappa-B, SRF and AP1 transactivation.
• Source: HEK293
• Species: Human
• Tag: Myc/DDK
• Molecular Mass: 86.4 kDa
• AA Sequence: MPALPLDQLQITHKDPKTGKLRTSP ALHPEQKADRYFVLYKPPPKDNIPA LVEEYLERATFVANDLDWLLALPHD KFWCQVIFDETLQKCLDSYLRYVPR KFDEGVASAPEVVDMQKRLHRSVFL TFLRMSTHKESKDHFISPSAFGEIL YNNFLFDIPKILDLCVLFGKGNSPL LQKMIGNIFTQQPSYYSDLDETLPT ILQVFSNILQHCGLQGDGANTTPQK LEERGRLTPSDMPLLELKDIVLYLC DTCTTLWAFLDIFPLACQTFQKHDF CYRLASFYEAAIPEMESAIKKRRLE DSKLLGDLWQRLSHSRKKLMEIFHI ILNQICLLPILESSCDNIQGFIEEF LQIFSSLLQEKRFLRDYDALFPVAE DISLLQQASSVLDETRTAYILQAVE SAWEGVDRRKATDAKDPSVIEEPNG EPNGVTVTAEAVSQASSHPENSEEE ECMGAAAAVGPAMCGVELDSLISQV KDLLPDLGEGFILACLEYYHYDPEQ VINNILEERLAPTLSQLDRNLDREM KPDPTPLLTSRHNVFQNDEFDVFSR DSVDLSRVHKGKSTRKEENTRSLLN DKRAVAAQRQRYEQYSVVVEEVPLQ PGESLPYHSVYYEDEYDDTYDGNQV GANDADSDDELISRRPFTIPQVLRT KVPREGQEEDDDDEEDDADEEAPKP DHFVQDPAVLREKAEARRMAFLAKK GYRHDSSTAVAGSPRGHGQSRETTQ ERRKKEANKATRANHNRRTMADRKR SKGMIPSTRTRPLEQKLISEEDLAA NDILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 3 months from receipt of products under proper storage and handling conditions.
• Storage: Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
• Concentration: 50 μg/mL as determined by BCA
• Storage Buffer: 100 mM glycine, 25 mM Tris-HCl, pH 7.3.

Gene Information

• Gene Name: ASCC2 activating signal cointegrator 1 complex subunit 2 [ Homo sapiens (human) ]
• Official Symbol: ASCC2
• Synonyms: ASCC2; activating signal cointegrator 1 complex subunit 2; ASC 1 complex subunit P100; ASC1p100; DKFZp586O0223; FLJ21588; ASC-1 complex subunit P100; trip4 complex subunit p100; p100
• Gene ID: 84164
• mRNA Refseq: NM_032204
• Protein Refseq: NP_115580
• MIM: 614216
• UniProt ID: Q9H1I8

Reviews

03/07/2020

Another advantage of using ASCC2 protein in trials is its potential as a therapeutic agent.

05/13/2017

Collaborative discussions with the manufacturer can also help optimize experimental protocols and provide insights into the best practices in working with ANXA5B.

02/18/2017

The manufacturer can further support researchers by providing customized solutions tailored to their specific needs.

Q&As

Is there any association between ASCC2 and human diseases?

Currently, there are no known human diseases directly associated with ASCC2. However, dysregulation of transcriptional coactivation complexes, in which ASCC2 is involved, can contribute to various diseases.

Does ASCC2 have any impact on cellular metabolism?

The direct impact of ASCC2 on cellular metabolism is not well-documented. However, given its role in transcriptional regulation, it may indirectly influence metabolic processes by controlling gene expression.

Does ASCC2 undergo any post-translational modifications?

The post-translational modifications of ASCC2 have not been extensively studied. However, it is possible that ASCC2 may undergo modifications such as phosphorylation or acetylation, which can regulate its activity.

How is ASCC2 localized within the cell?

ASCC2 is primarily localized in the nucleus, where it carries out its functions in gene expression regulation.

Is ASCC2 involved in DNA repair processes?

ASCC2 is known to be involved in DNA repair processes as part of the ASC-1 complex. It contributes to the repair of DNA double-strand breaks, promoting genome stability.