Recombinant Human ATP2A2 Protein (M1-S1042 end), Strep II/His tagged

• Cat.No.: ATP2A2-1268H
• Product Overview: Recombinant Human 10His-Strep II-eGFP-SERCA2b(M1-S1042 end) Protein was expressed in Mammalian cell.

Specification

• Description: This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen. Involved in autophagy in response to starvation. Upon interaction with VMP1 and activation, controls ER-isolation membrane contacts for autophagosome formation. Also modulates ER contacts with lipid droplets, mitochondria and endosomes.
• Source: Mammalian cell
• Species: Human
• Tag: Strep II/His
• Form: Liquid
• Protein Length: M1-S1042 end
• Endotoxin: < 0.01 EU per μg of the protein
• Purity: 85%
• Stability: Samples are stable for up to twelve months from date of receipt at -20 to -80 centigrade.
• Storage: Store it under sterile conditions at -20 to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Storage Buffer: Supplied as sterile 50 mM HEPES pH 7.5, 100 mM KCl, 1mM DTT, 1mM CaCl2, 1mM MgCl2, 0.001% (w/v) LMNG
• Shipping: It is shipped out with blue ice.

Gene Information

• Gene Name: ATP2A2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 [ Homo sapiens (human) ]
• Official Symbol: ATP2A2
• Synonyms: ATP2A2; ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2; DD; DAR; ATP2B; SERCA2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2; ATPase Ca++ transporting cardiac muscle slow twitch 2; ATPase, Ca++ dependent, slow-twitch, cardiac muscle-2; SR Ca(2+)-ATPase 2; calcium pump 2; cardiac Ca2+ ATPase; endoplasmic reticulum class 1/2 Ca(2+) ATPase; EC 7.2.2.10
• Gene ID: 488
• mRNA Refseq: NM_170665
• Protein Refseq: NP_733765
• MIM: 108740
• UniProt ID: P16615

Reviews

08/09/2020

Because ATP2A2 has a short half-life and high clearance, it better prevents drug accumulation in the body, thereby reducing the risk of side effects caused by long-term use.

07/28/2019

The production process of ATP2A2 focuses on harmonious coexistence with nature, realizes zero pollution in the production process, and brings a positive impact on the environment.

03/25/2019

It can maintain stable performance even in extremely harsh environments, which is a rare quality.

Q&As

Are ATP2A2 recombinant protein mutations associated with human nervous system related diseases?

Mutations in the recombinant ATP2A2 protein are associated with several nervous system related diseases, such as neurodegenerative diseases and neurodysregulation.

What are the structural features of the recombinant ATP2A2 protein?

ATP2A2 protein is a calcium pump protein containing multiple membrane channels and ATP-binding sites for the regulation of intracellular calcium homeostasis.

Is the expression and function of recombinant ATP2A2 protein regulated in the nervous system?

Yes, the expression and function of ATP2A2 recombinant protein in the nervous system are regulated by complex mechanisms, including endogenous signaling pathways and cell-to-cell interactions.

Is there any polymorphic variation or mutation in ATP2A2 recombinant protein?

Yes, there are polymorphic variations or mutations in ATP2A2 recombinant protein, which may be related to the susceptibility and pathogenesis of nervous system related diseases.

What is the function of ATP2A2 recombinant protein in the nervous system?

The recombinant ATP2A2 protein is responsible for regulating calcium homeostasis and maintaining nerve cell communication in the nervous system.

Does the recombinant ATP2A2 protein interact with other proteins?

The recombinant ATP2A2 protein interacts with other membrane proteins, such as calcium channels and transporters, to regulate the function of nerve cells.