Recombinant Human ATRX protein, GST-tagged

• Cat.No.: ATRX-1028H
• Product Overview: Human ATRX full-length ORF ( AAH02521, 1 a.a. - 90 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: The protein encoded by this gene contains an ATPase/helicase domain, and thus it belongs to the SWI/SNF family of chromatin remodeling proteins. This protein is found to undergo cell cycle-dependent phosphorylation, which regulates its nuclear matrix and chromatin association, and suggests its involvement in the gene regulation at interphase and chromosomal segregation in mitosis. Mutations in this gene are associated with an X-linked mental retardation (XLMR) syndrome most often accompanied by alpha-thalassemia (ATRX) syndrome. These mutations have been shown to cause diverse changes in the pattern of DNA methylation, which may provide a link between chromatin remodeling, DNA methylation, and gene expression in developmental processes. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Aug 2013]
• Source: Wheat Germ
• Species: Human
• Tag: GST
• Molecular Mass: 35.53 kDa
• AA Sequence: MTAEPMSESKLNTLVQKLHDFLAHS SEESEETSSPPRLAMNQNTDKISGS GSNSDMMENSKEEGTSSSEKSKSSG SSRSKRKPSIVNKND
• Applications: Enzyme-linked Immunoabsorbent Assay; Western Blot (Recombinant protein); Antibody Production; Protein Array
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: ATRX alpha thalassemia/mental retardation syndrome X-linked [ Homo sapiens ]
• Official Symbol: ATRX
• Synonyms: ATRX; alpha thalassemia/mental retardation syndrome X-linked; alpha thalassemia/mental retardation syndrome X linked (RAD54 (S. cerevisiae) homolog) , JMS, Juberg Marsidi syndrome , RAD54; transcriptional regulator ATRX; RAD54 homolog (S. cerevisiae); XH2; XNP; RAD54 homolog; X-linked helicase II; Zinc finger helicase; helicase 2, X-linked; X-linked nuclear protein; ATP-dependent helicase ATRX; DNA dependent ATPase and helicase; alpha thalassemia/mental retardation syndrome X-linked (RAD54 homolog, S. cerevisiae); JMS; SHS; ATR2; SFM1; RAD54; MRXHF1; RAD54L; ZNF-HX; MGC2094
• Gene ID: 546
• mRNA Refseq: NM_000489
• Protein Refseq: NP_000480
• MIM: 300032
• UniProt ID: P46100

Reviews

10/20/2022

The purity of ATRX is very high, which can ensure the reliability of the experimental results and also facilitate the subsequent experimental operation.

10/26/2019

ATRX is really amazing. The results of every experiment are very consistent, which shows that its production process is very careful.

07/24/2019

This band positions of ATRX in Western blot were accurate and showed good specificity.

Q&As

What progress has been made in the research of ATRX gene?

The research on ATRX gene mainly focuses on its function and regulatory mechanism, and its relationship with genetic diseases and cancer. So far, several important findings on ATRX gene function and regulation have been made.

Is ATRX gene regulated?

Yes, ATRX gene expression is affected by a variety of regulatory factors, including transcription factor binding, DNA methylation status, etc. These regulatory mechanisms ensure the adaptability and stability of the ATRX gene.

What diseases or symptoms are caused by ATRX mutation?

ATRX gene mutation can lead to Alpha thalassemia/mental retardation syndrome X-linked. The main features of this syndrome include mental retardation, developmental delay, craniofacial deformity, anemia, etc.

What is the expression pattern of ATRX gene?

ATRX gene is widely expressed in human body, but its expression level may vary in different tissues and organs. Its expression is higher in brain, kidney, muscle and other tissues.

Are there other genes that interact with the ATRX gene?

ATRX genes may interact with other genes related to chromatin structure and DNA repair. For example, ATRX interacts with Death-domain associated protein (DAXX) to participate in chromatin repair and regulation.

Is ATRX gene involved in DNA repair?

Yes, the ATRX gene is involved in the regulation of DNA repair. Together with other proteins, it maintains the normal progression of DNA repair by maintaining chromatin structure and regulating gene expression.