Recombinant Human AVEN Protein, DYKDDDDK-tagged

• Cat.No.: AVEN-01H
• Product Overview: Recombinant protein from the full-length sequence of Homo sapiens apoptosis and caspase activation inhibitor (AVEN) (NM_020371), with a DYKDDDDK tag was expressed in human cells.

Specification

• Description: Involved in negative regulation of apoptotic process. Located in membrane.
• Source: Human Cells
• Species: Human
• Tag: DYKDDDDK
• Molecular Mass: 38.3 kDa
• Endotoxin: < 0.1 ng/μg of protein (<1EU/μg)
• Purity: > 90% by SDS-PAGE gel and Coomassie Blue staining
• Applications: Antigens, Western, ELISA and other in vitro binding or in vivo functional assays, and protein-protein interaction studies; For research & development use only!
• Storage Buffer: Purified protein formulated in a sterile solution of TBS buffer, pH7.4, without any preservatives

Gene Information

• Gene Name: AVEN apoptosis and caspase activation inhibitor [ Homo sapiens (human) ]
• Official Symbol: AVEN
• Synonyms: AVEN; apoptosis and caspase activation inhibitor; PDCD12; cell death regulator Aven; apoptosis, caspase activation inhibitor; programmed cell death 12
• Gene ID: 57099
• mRNA Refseq: NM_020371
• Protein Refseq: NP_065104
• MIM: 605265
• UniProt ID: Q9NQS1

Reviews

03/22/2023

Endotoxin levels are low and do not interfere with the experimental results.

03/10/2021

AVEN is highly expressed and can be easily detected.

06/30/2020

It performs well in Western blots, even if stored for a long time, it will not affect its performance.

Q&As

What diseases are associated with AVEN?

AVEN has been implicated in the development of some cancers, particularly acute promyelocytic leukemia (APL). The high expression of AVEN is closely related to the pathogenesis of APL.

How do you regulate AVEN's activities?

The activity of AVEN can be modulated by different regulatory mechanisms, including phosphorylation and dephosphorylation, interaction with other proteins, and small molecule regulation. These regulatory mechanisms can affect the function of AVEN.

What are the potential applications of AVEN in cancer therapy?

Potential applications of AVEN in cancer therapy include therapeutic targets, diagnostic markers, and drug development candidates. Drug development for AVEN may help treat certain types of cancer.

Does AVEN inhibit apoptosis?

It can interact with other members of the Bcl-2 protein family to inhibit the activation of the mitochondrial apoptotic pathway by blocking the activation of the pro-apoptotic proteins Bax and Bak.

Does AVEN function differently in different cell types?

The role of AVEN in different types of cells may vary. Its function may be affected by factors such as cell type, tissue, and stage of development.

How is the expression level of AVEN regulated?

The expression level of AVEN is regulated by a variety of factors, including transcription factors, epigenetic modifications, and signal transduction pathways. These factors can affect the transcription and translation process of the AVEN gene, thereby regulating its expression level in cells.