AVEN
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Official Full Name
apoptosis, caspase activation inhibitor
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Overview
Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells. Disruption of this process has been implicated in a variety of diseases such as cancer. AVEN is a recently discovered protein that blocks apoptosis induced by Apaf-1 and caspase-9. It is thought that AVEN functions by binding to Bcl-xL, an antiapoptotic member of the Bcl-2 family, and to Apaf-1, possibly interfering with the ability of Apaf-1 to self-associate, suggesting that AVEN impedes Apaf-1-mediated caspase activation. Higher levels of AVEN mRNA are seen in patients with acute leukemia than in control patients, suggesting that AVEN may be useful as a prognostic indicator in leukemia patients. -
Synonyms
AVEN; apoptosis, caspase activation inhibitor; PDCD12; cell death regulator aven; programmed cell death 12; OTTHUMP00000159733;
- Recombinant Proteins
- Chicken
- Human
- Mouse
- Zebrafish
- HEK293
- HEK293T
- Human Cell
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- DYKDDDDK
- GST
- His
- Myc
- DDK
- Myc|DDK
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
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Human | AVEN-1041H | Recombinant Human AVEN protein, GST-tagged | Wheat Germ | GST | ||
Human | AVEN-3208H | Recombinant Human AVEN Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293T | Myc/DDK | ||
Human | AVEN-01H | Recombinant Human AVEN Protein, DYKDDDDK-tagged | Human Cell | DYKDDDDK | ||
Human | AVEN-3034H | Recombinant Human AVEN Protein, MYC/DDK-tagged | HEK293 | Myc/DDK | ||
Human | AVEN-1254HF | Recombinant Full Length Human AVEN Protein, GST-tagged | In Vitro Cell Free System | GST | 362 amino acids | |
Mouse | Aven-1790M | Recombinant Mouse Aven Protein, Myc/DDK-tagged | HEK293T | Myc/DDK | ||
Zebrafish | AVEN-4283Z | Recombinant Zebrafish AVEN | Mammalian Cell | His | ||
Chicken | AVEN-1249C | Recombinant Chicken AVEN | Mammalian Cell | His |
- AVEN Related Articles
AVEN involved in several pathways and played different roles in them. We selected most pathways AVEN participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with AVEN were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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AVEN has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by AVEN itself. We selected most functions AVEN had, and list some proteins which have the same functions with AVEN. You can find most of the proteins on our site.
Function | Related Protein |
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AVEN has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AVEN here. Most of them are supplied by our site. Hope this information will be useful for your research of AVEN.
- Q&As
- Reviews
Q&As (6)
Ask a questionAVEN has been implicated in the development of some cancers, particularly acute promyelocytic leukemia (APL). The high expression of AVEN is closely related to the pathogenesis of APL.
The activity of AVEN can be modulated by different regulatory mechanisms, including phosphorylation and dephosphorylation, interaction with other proteins, and small molecule regulation. These regulatory mechanisms can affect the function of AVEN.
Potential applications of AVEN in cancer therapy include therapeutic targets, diagnostic markers, and drug development candidates. Drug development for AVEN may help treat certain types of cancer.
It can interact with other members of the Bcl-2 protein family to inhibit the activation of the mitochondrial apoptotic pathway by blocking the activation of the pro-apoptotic proteins Bax and Bak.
The role of AVEN in different types of cells may vary. Its function may be affected by factors such as cell type, tissue, and stage of development.
The expression level of AVEN is regulated by a variety of factors, including transcription factors, epigenetic modifications, and signal transduction pathways. These factors can affect the transcription and translation process of the AVEN gene, thereby regulating its expression level in cells.
Customer Reviews (3)
Write a reviewEndotoxin levels are low and do not interfere with the experimental results.
AVEN is highly expressed and can be easily detected.
It performs well in Western blots, even if stored for a long time, it will not affect its performance.
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