Recombinant Human AVEN protein, GST-tagged
Cat.No. : | AVEN-1041H |
Product Overview : | Human AVEN full-length ORF ( NP_065104.1, 1 a.a. - 362 a.a.) recombinant protein with GST-tag at N-terminal. |
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Description : | AVEN (Apoptosis And Caspase Activation Inhibitor) is a Protein Coding gene. Diseases associated with AVEN include Schizoid Personality Disorder and Alzheimer Disease Mitochondrial. Among its related pathways are Apoptosis and Autophagy. |
Source : | Wheat Germ |
Species : | Human |
Tag : | GST |
Molecular Mass : | 64.9 kDa |
AA Sequence : | MQAERGARGGRGRRPGRGRPGGDRH SERPGAAAAVARGGGGGGGGDGGGR RGRGRGRGFRGARGGRGGGGAPRGS RREPGGWGAGASAPVEDDSDAETYG EENDEQGNYSKRKIVSNWDRYQDIE KEVNNESGESQRGTDFSVLLSSAGD SFSQFRFAEEKEWDSEASCPKQNSA FYVDSELLVRALQELPLCLRLNVAA ELVQGTVPLEVPQVKPKRTDDGKGL GMQLKGPLGPGGRGPIFELKSVAAG CPVLLGKDNPSPGPSRDSQKPTSPL QSAGDHLEEELDLLLNLDAPIKEGD NILPDQTSQDLKSKEDGEVVQEEEV CAKPSVTEEKNMEPEQPSTSKNVTE EELEDWLDSMIS |
Applications : | Enzyme-linked Immunoabsorbent Assay; Western Blot (Recombinant protein); Antibody Production; Protein Array |
Notes : | Best use within three months from the date of receipt of this protein. |
Storage : | Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing. |
Storage Buffer : | 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer. |
Gene Name : | AVEN apoptosis, caspase activation inhibitor [ Homo sapiens ] |
Official Symbol : | AVEN |
Synonyms : | AVEN; apoptosis, caspase activation inhibitor; cell death regulator Aven; cell death regulator aven; PDCD12; programmed cell death 12; |
Gene ID : | 57099 |
mRNA Refseq : | NM_020371 |
Protein Refseq : | NP_065104 |
MIM : | 605265 |
UniProt ID : | Q9NQS1 |
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Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (6)
Ask a questionAVEN has been implicated in the development of some cancers, particularly acute promyelocytic leukemia (APL). The high expression of AVEN is closely related to the pathogenesis of APL.
The activity of AVEN can be modulated by different regulatory mechanisms, including phosphorylation and dephosphorylation, interaction with other proteins, and small molecule regulation. These regulatory mechanisms can affect the function of AVEN.
Potential applications of AVEN in cancer therapy include therapeutic targets, diagnostic markers, and drug development candidates. Drug development for AVEN may help treat certain types of cancer.
It can interact with other members of the Bcl-2 protein family to inhibit the activation of the mitochondrial apoptotic pathway by blocking the activation of the pro-apoptotic proteins Bax and Bak.
The role of AVEN in different types of cells may vary. Its function may be affected by factors such as cell type, tissue, and stage of development.
The expression level of AVEN is regulated by a variety of factors, including transcription factors, epigenetic modifications, and signal transduction pathways. These factors can affect the transcription and translation process of the AVEN gene, thereby regulating its expression level in cells.
Customer Reviews (3)
Write a reviewEndotoxin levels are low and do not interfere with the experimental results.
AVEN is highly expressed and can be easily detected.
It performs well in Western blots, even if stored for a long time, it will not affect its performance.
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