Recombinant Human CACNG7, GST-tagged

• Cat.No.: CACNG7-10647H
• Product Overview: Recombinant Human CACNG7 protein, fused to GST-tag, was expressed in E.coli and purified by GSH-sepharose.

Specification

• Description: The protein encoded by this gene is a type II transmembrane AMPA receptor regulatory protein (TARP). TARPs regulate both trafficking and channel gating of the AMPA receptors. This gene is part of a functionally diverse eight-member protein subfamily of the PMP-22/EMP/MP20 family and is located in a cluster with two family members, a type I TARP and a calcium channel gamma subunit.
• Source: E.coli
• Species: Human
• Tag: GST
• Protein length: 154-275a.a.
• Storage: The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
• Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol.

Gene Information

• Gene Name: CACNG7 calcium channel, voltage-dependent, gamma subunit 7 [ Homo sapiens ]
• Official Symbol: CACNG7
• Synonyms: CACNG7; calcium channel, voltage-dependent, gamma subunit 7; voltage-dependent calcium channel gamma-7 subunit; TARP gamma-7; transmembrane AMPAR regulatory protein gamma-7; neuronal voltage-gated calcium channel gamma-7 subunit
• Gene ID: 59284
• mRNA Refseq: NM_031896
• Protein Refseq: NP_114102
• MIM: 606899
• UniProt ID: P62955
• Chromosome Location: 19q13.4
• Pathway: Arrhythmogenic right ventricular cardiomyopathy (ARVC), organism-specific biosystem; Arrhythmogenic right ventricular cardiomyopathy (ARVC), conserved biosystem; Cardiac muscle contraction, organism-specific biosystem; Cardiac muscle contraction, conserved biosystem; Dilated cardiomyopathy, organism-specific biosystem; Dilated cardiomyopathy, conserved biosystem; Hypertrophic cardiomyopathy (HCM), organism-specific biosystem
• Function: voltage-gated calcium channel activity; voltage-gated ion channel activity

Reviews

09/06/2021

Quick and precise protein quantification services.

05/08/2021

Excellent results, highly reliable protein assays.

03/05/2021

Saves time with efficient sample processing.

Q&As

Are there any specific diseases or conditions linked to anomalies in CACNG7?

Dysfunctions or mutations in CACNG7 have been suggested in certain neurological disorders, though more detailed research is essential for specific associations.

How might genetic variants in the CACNG7 gene affect its regulatory role?

Genetic variations in the CACNG7 gene can impact its regulatory influence on calcium channels, potentially affecting neural communication and related processes.

What is the primary biological function of CACNG7 in the context of calcium channels?

CACNG7 acts as an auxiliary subunit, influencing the modulation of activity, trafficking, and surface expression of voltage-gated calcium channels.

Which proteins are known to directly interact with CACNG7?

CACNG7 mainly interacts with the alpha-1 subunit of calcium channels, and may also have associations with other proteins in the channel complex.

How does CACNG7 modulate the activity of associated calcium channels?

Through its interaction, CACNG7 can influence the channel's gating dynamics, cellular localization, and calcium ion permeation characteristics.

In which human tissues or cells is CACNG7 predominantly expressed?

CACNG7 is primarily expressed in neural tissues, with significant levels in particular regions of the brain.

Have any post-translational modifications been documented on CACNG7?

Techniques like mass spectrometry might uncover potential post-translational modifications on CACNG7.