Recombinant Human CDK6 Protein, His-tagged
Cat.No. : | CDK6-728H |
Product Overview : | Recombinant Human CDK6 Protein (Met1-Ala326) with His tag was expressed in E. coli. |
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Description : | The protein encoded by this gene is a member of the CMGC family of serine/threonine protein kinases. This kinase is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression and G1/S transition. The activity of this kinase first appears in mid-G1 phase, which is controlled by the regulatory subunits including D-type cyclins and members of INK4 family of CDK inhibitors. This kinase, as well as CDK4, has been shown to phosphorylate, and thus regulate the activity of, tumor suppressor protein Rb. Altered expression of this gene has been observed in multiple human cancers. A mutation in this gene resulting in reduced cell proliferation, and impaired cell motility and polarity, and has been identified in patients with primary microcephaly. |
Source : | E. coli |
Species : | Human |
Tag : | N-His |
Form : | Freeze-dried powder |
Molecular Mass : | Predicted Molecular Mass: 40.6 kDa; Accurate Molecular Mass: 41 kDa |
Protein length : | Met1-Ala326 |
Purity : | > 95% |
Applications : | Positive Control; Immunogen; SDS-PAGE; WB. |
Stability : | The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 centigrade for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition. |
Storage : | Avoid repeated freeze/thaw cycles. Store at 2-8 centigrade for one month. Aliquot and store at -80 centigrade for 12 months. |
Storage Buffer : | 20mM Tris, 150mM NaCl, pH8.0, containing 1mM EDTA, 1mM DTT, 0.01% SKL, 5% Trehalose and Proclin300. |
Reconstitution : | Reconstitute in 20mM Tris, 150mM NaCl (pH8.0) to a concentration of 0.1-1.0 mg/mL. Do not vortex. |
Gene Name : | CDK6 cyclin-dependent kinase 6 [ Homo sapiens (human) ] |
Official Symbol : | CDK6 |
Synonyms : | CDK6; cyclin-dependent kinase 6; PLSTIRE; cell division protein kinase 6; serine/threonine-protein kinase PLSTIRE; MGC59692; |
Gene ID : | 1021 |
mRNA Refseq : | NM_001145306 |
Protein Refseq : | NP_001138778 |
MIM : | 603368 |
UniProt ID : | Q00534 |
Products Types
◆ Recombinant Protein | ||
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CDK6-565H | Recombinant Human CDK6 Protein, His (Fc)-Avi-tagged | +Inquiry |
CDK6-1028H | Recombinant Human CDK6 Protein, GST-Tagged | +Inquiry |
CDK6-614R | Recombinant Rhesus Macaque CDK6 Protein, His (Fc)-Avi-tagged | +Inquiry |
CDK6-27H | Recombinant Human CDK6/CCND2 Protein (Full length), N-GST-tagged | +Inquiry |
◆ Lysates | ||
CDK6-7622HCL | Recombinant Human CDK6 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (6)
Ask a questionThe expression level of CDK6 is regulated by a variety of factors, including transcription factors, epigenetic modifications, and signal transduction pathways. These factors can affect the transcription and translation processes of the CDK6 gene, thereby regulating its expression level in cells.
There are several challenges in the development of CDK6 inhibitors, including issues such as inhibitor selectivity, drug resistance, and drug delivery. In addition, since CDK6 also has a certain function in normal cells, the side effects of inhibitors are also a factor to consider.
It plays an important role in stem cell biology. It is involved in the process of self-renewal and differentiation of stem cells, as well as in determining the fate of stem cells. By regulating the activity of CDK6, it is possible to influence the proliferation and fate selection of stem cells.
CDK6 inhibitors have been developed as potential anti-cancer drugs and have shown some efficacy in clinical trials. They block the progression of the cell cycle by inhibiting the activity of CDK6, thereby inhibiting the proliferation of cancer cells.
The activity of CDK6 is regulated at multiple levels, including binding to other cyclins and inhibitors, phosphorylation and dephosphorylation events, and transcriptional and post-translational modifications.
The role of CDK6 in different types of cancer may vary. It may act as a promoter in some cancers and as a suppressant in others. This difference can be related to factors such as the type, stage, and genetic background of the cancer.
Customer Reviews (3)
Write a reviewThe results obtained after analysis by SDS-PAGE or Western blot were good.
It has a wide range of applications and can be used in various biological experiments.
The purity of CDK6 is good, and the experimental results obtained are very accurate.
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