Recombinant Mouse Cdk6 Protein, MYC/DDK-tagged
Cat.No. : | Cdk6-867M |
Product Overview : | Purified recombinant protein of full-length mouse cyclin-dependent kinase 6 (Cdk6), with C-terminal MYC/DDK tag, was expressed in HEK293T cells. |
- Specification
- Gene Information
- Related Products
- Download
Description : | This gene encodes a member of the cyclin dependent kinase family of proteins that play important roles in the progression and regulation of the cell cycle. The encoded protein binds to a D-type cyclin to form an active kinase complex to regulate progression through the G1 phase of the cell cycle. Mice lacking the encoded protein exhibit thymic and splenic hypoplasia, and hematopoietic defects such as reduced number of megakaryocytes and erythrocytes. A pseudogene of this gene has been defined on chromosome 4. |
Source : | HEK293T |
Species : | Mouse |
Tag : | MYC/DDK |
Molecular Mass : | 37.5 kDa |
Purity : | >80% as determined by SDS-PAGE and Coomassie blue staining |
Stability : | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
Storage : | Store at -80 centigrade after receiving vials. |
Concentration : | >50 µg/mL as determined by microplate BCA method |
Storage Buffer : | 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol. |
Gene Name : | Cdk6 cyclin-dependent kinase 6 [ Mus musculus (house mouse) ] |
Official Symbol : | Cdk6 |
Synonyms : | Cdk6; cyclin-dependent kinase 6; Crk2; AI504062; cyclin-dependent kinase 6; CR2 protein kinase; cell division protein kinase 6; serine/threonine-protein kinase PLSTIRE; EC 2.7.11.22 |
Gene ID : | 12571 |
mRNA Refseq : | NM_009873 |
Protein Refseq : | NP_034003 |
UniProt ID : | Q64261 |
Products Types
◆ Recombinant Protein | ||
CDK6-1028H | Recombinant Human CDK6 Protein, GST-Tagged | +Inquiry |
CDK6-565H | Recombinant Human CDK6 Protein, His (Fc)-Avi-tagged | +Inquiry |
CDK6/CCND3-278H | Recombinant Human CDK6/CCND3, His-tagged, Active | +Inquiry |
CDK6-1032H | Active Recombinant Human CDK6 Protein, GST-Tagged | +Inquiry |
CDK6-728H | Recombinant Human CDK6 Protein, His-tagged | +Inquiry |
◆ Lysates | ||
CDK6-7622HCL | Recombinant Human CDK6 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
- Q&As
- Reviews
Q&As (6)
Ask a questionThe expression level of CDK6 is regulated by a variety of factors, including transcription factors, epigenetic modifications, and signal transduction pathways. These factors can affect the transcription and translation processes of the CDK6 gene, thereby regulating its expression level in cells.
There are several challenges in the development of CDK6 inhibitors, including issues such as inhibitor selectivity, drug resistance, and drug delivery. In addition, since CDK6 also has a certain function in normal cells, the side effects of inhibitors are also a factor to consider.
It plays an important role in stem cell biology. It is involved in the process of self-renewal and differentiation of stem cells, as well as in determining the fate of stem cells. By regulating the activity of CDK6, it is possible to influence the proliferation and fate selection of stem cells.
CDK6 inhibitors have been developed as potential anti-cancer drugs and have shown some efficacy in clinical trials. They block the progression of the cell cycle by inhibiting the activity of CDK6, thereby inhibiting the proliferation of cancer cells.
The activity of CDK6 is regulated at multiple levels, including binding to other cyclins and inhibitors, phosphorylation and dephosphorylation events, and transcriptional and post-translational modifications.
The role of CDK6 in different types of cancer may vary. It may act as a promoter in some cancers and as a suppressant in others. This difference can be related to factors such as the type, stage, and genetic background of the cancer.
Customer Reviews (3)
Write a reviewThe results obtained after analysis by SDS-PAGE or Western blot were good.
It has a wide range of applications and can be used in various biological experiments.
The purity of CDK6 is good, and the experimental results obtained are very accurate.
Ask a Question for All Cdk6 Products
Required fields are marked with *
My Review for All Cdk6 Products
Required fields are marked with *
Inquiry Basket