Recombinant Human CDK6 Protein, Myc/DDK-tagged, C13 and N15-labeled
Cat.No. : | CDK6-1883H |
Product Overview : | CDK6 MS Standard C13 and N15-labeled recombinant protein (NP_001250) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells. |
- Specification
- Gene Information
- Related Products
- Download
Description : | The protein encoded by this gene is a member of the CMGC family of serine/threonine protein kinases. This kinase is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression and G1/S transition. The activity of this kinase first appears in mid-G1 phase, which is controlled by the regulatory subunits including D-type cyclins and members of INK4 family of CDK inhibitors. This kinase, as well as CDK4, has been shown to phosphorylate, and thus regulate the activity of, tumor suppressor protein Rb. Altered expression of this gene has been observed in multiple human cancers. A mutation in this gene resulting in reduced cell proliferation, and impaired cell motility and polarity, and has been identified in patients with primary microcephaly. |
Source : | HEK293 |
Species : | Human |
Tag : | Myc/DDK |
Molecular Mass : | 36.9 kDa |
AA Sequence : | MEKDGLCRADQQYECVAEIGEGAYG KVFKARDLKNGGRFVALKRVRVQTG EEGMPLSTIREVAVLRHLETFEHPN VVRLFDVCTVSRTDRETKLTLVFEH VDQDLTTYLDKVPEPGVPTETIKDM MFQLLRGLDFLHSHRVVHRDLKPQN ILVTSSGQIKLADFGLARIYSFQMA LTSVVVTLWYRAPEVLLQSSYATPV DLWSVGCIFAEMFRRKPLFRGSSDV DQLGKILDVIGLPGEEDWPRDVALP RQAFHSKSAQPIEKFVTDIDELGKD LLLKCLTFNPAKRISAYSALSHPYF QDLERCKENLDSHLPPSQNTSELNT ATRTRPLEQKLISEEDLAANDILDY KDDDDKV |
Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining |
Stability : | Stable for 3 months from receipt of products under proper storage and handling conditions. |
Storage : | Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
Concentration : | 50 μg/mL as determined by BCA |
Storage Buffer : | 100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
Gene Name : | CDK6 cyclin-dependent kinase 6 [ Homo sapiens (human) ] |
Official Symbol : | CDK6 |
Synonyms : | CDK6; cyclin-dependent kinase 6; PLSTIRE; cell division protein kinase 6; serine/threonine-protein kinase PLSTIRE; MGC59692; |
Gene ID : | 1021 |
mRNA Refseq : | NM_001259 |
Protein Refseq : | NP_001250 |
MIM : | 603368 |
UniProt ID : | Q00534 |
Products Types
◆ Recombinant Protein | ||
Cdk6-867M | Recombinant Mouse Cdk6 Protein, MYC/DDK-tagged | +Inquiry |
CDK6-1032H | Active Recombinant Human CDK6 Protein, GST-Tagged | +Inquiry |
CDK6-565H | Recombinant Human CDK6 Protein, His (Fc)-Avi-tagged | +Inquiry |
CDK6-1028H | Recombinant Human CDK6 Protein, GST-Tagged | +Inquiry |
CDK6-614R | Recombinant Rhesus Macaque CDK6 Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Lysates | ||
CDK6-7622HCL | Recombinant Human CDK6 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
- Q&As
- Reviews
Q&As (6)
Ask a questionThe expression level of CDK6 is regulated by a variety of factors, including transcription factors, epigenetic modifications, and signal transduction pathways. These factors can affect the transcription and translation processes of the CDK6 gene, thereby regulating its expression level in cells.
There are several challenges in the development of CDK6 inhibitors, including issues such as inhibitor selectivity, drug resistance, and drug delivery. In addition, since CDK6 also has a certain function in normal cells, the side effects of inhibitors are also a factor to consider.
It plays an important role in stem cell biology. It is involved in the process of self-renewal and differentiation of stem cells, as well as in determining the fate of stem cells. By regulating the activity of CDK6, it is possible to influence the proliferation and fate selection of stem cells.
CDK6 inhibitors have been developed as potential anti-cancer drugs and have shown some efficacy in clinical trials. They block the progression of the cell cycle by inhibiting the activity of CDK6, thereby inhibiting the proliferation of cancer cells.
The activity of CDK6 is regulated at multiple levels, including binding to other cyclins and inhibitors, phosphorylation and dephosphorylation events, and transcriptional and post-translational modifications.
The role of CDK6 in different types of cancer may vary. It may act as a promoter in some cancers and as a suppressant in others. This difference can be related to factors such as the type, stage, and genetic background of the cancer.
Customer Reviews (3)
Write a reviewThe results obtained after analysis by SDS-PAGE or Western blot were good.
It has a wide range of applications and can be used in various biological experiments.
The purity of CDK6 is good, and the experimental results obtained are very accurate.
Ask a Question for All CDK6 Products
Required fields are marked with *
My Review for All CDK6 Products
Required fields are marked with *
Inquiry Basket