Recombinant Human CFL2, GST-tagged

• Cat.No.: CFL2-11143H
• Product Overview: Recombinant Human CFL2 protein, fused to GST-tag, was expressed in E.coli and purified by GSH-sepharose.

Specification

• Description: This gene encodes an intracellular protein that is involved in the regulation of actin-filament dynamics. This protein is a major component of intranuclear and cytoplasmic actin rods. It can bind G- and F-actin in a 1:1 ratio of cofilin to actin, and it reversibly controls actin polymerization and depolymerization in a pH-dependent manner. Mutations in this gene cause nemaline myopathy type 7, a form of congenital myopathy. Alternative splicing results in multiple transcript variants.
• Source: E.coli
• Species: Human
• Tag: GST
• Protein length: 1-166a.a.
• Storage: The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
• Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol.

Gene Information

• Gene Name: CFL2 cofilin 2 (muscle) [ Homo sapiens ]
• Official Symbol: CFL2
• Synonyms: CFL2; cofilin 2 (muscle); cofilin-2; cofilin, muscle isoform; NEM7
• Gene ID: 1073
• mRNA Refseq: NM_001243645
• Protein Refseq: NP_001230574
• MIM: 601443
• UniProt ID: Q9Y281
• Chromosome Location: 14q13.2
• Pathway: Axon guidance, organism-specific biosystem; Axon guidance, conserved biosystem; Caspase cascade in apoptosis, organism-specific biosystem; Fc gamma R-mediated phagocytosis, organism-specific biosystem; Fc gamma R-mediated phagocytosis, conserved biosystem; G13 Signaling Pathway, organism-specific biosystem; Pertussis, organism-specific biosystem
• Function: actin binding; protein binding

Reviews

05/23/2022

It has been extensively used in protein-protein interaction studies, enzymatic assays, and structural analyses, showcasing its reliability and adaptability in diverse research areas.

11/13/2021

I am certain of obtaining reliable and reproducible results, enabling me to contribute to scientific progress and make new discoveries.

11/07/2017

I highly recommend the CFL2 Protein for its outstanding performance in ELISA assays.

Q&As

Are there any ongoing clinical trials targeting CFL2 for therapeutic purposes?

It's important to check current clinical trial databases for the latest information, but research exploring CFL2 as a therapeutic target is ongoing.

How does CFL2 relate to cardiac diseases?

CFL2 is involved in maintaining the structure and function of cardiac muscle cells, and its dysregulation has been linked to conditions such as cardiomyopathies.

Are there diagnostic applications for CFL2 in muscle-related disorders?

Research suggests that analyzing CFL2 levels and activity could serve as diagnostic markers for certain muscle-related disorders.

How does CFL2 interact with other proteins in the context of muscle function?

CFL2 interacts with actin and other regulatory proteins to modulate the dynamics of the actin cytoskeleton, influencing cellular processes crucial for muscle function.

Can CFL2 be a potential therapeutic target for muscle-related disorders?

Investigating CFL2 as a therapeutic target is an active area of research, with the aim of developing interventions for conditions characterized by impaired muscle function.