Recombinant Human CHAC1 Protein (K2-V222), His/Strep tagged

• Cat.No.: CHAC1-0223H
• Product Overview: Recombinant Human 6His-StrepII-TEV-GG-CHAC1(K2-V222 end) Protein was expressed in E. coli.

Specification

• Description: Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides. Glutathione depletion is an important factor for apoptosis initiation and execution. Acts as a pro-apoptotic component of the unfolded protein response pathway by mediating the pro-apoptotic effects of the ATF4-ATF3-DDIT3/CHOP cascade. Negative regulator of Notch signaling pathway involved in embryonic neurogenesis: acts by inhibiting Notch cleavage by furin, maintaining Notch in an immature inactive form, thereby promoting neurogenesis in embryos.
• Source: E. coli
• Species: Human
• Tag: His/Strep
• Form: Liquid
• Protein Length: K2-V222
• Endotoxin: < 0.01 EU per μg of the protein
• Purity: 90%
• Stability: Samples are stable for up to twelve months from date of receipt at -20 to -80 centigrade.
• Storage: Store it under sterile conditions at -20 to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Storage Buffer: Supplied as sterile 50 mM Tris-HCl (pH7.5), 200 mM NaCl, 20% glycerol
• Shipping: It is shipped out with blue ice.

Gene Information

• Gene Name: CHAC1 ChaC, cation transport regulator homolog 1 (E. coli) [ Homo sapiens (human) ]
• Official Symbol: CHAC1
• Gene ID: 79094
• mRNA Refseq: NM_024111
• Protein Refseq: NP_077016
• MIM: 614587
• UniProt ID: Q9BUX1