Recombinant Human COL17A1 protein, His-tagged

• Cat.No.: COL17A1-4947H
• Product Overview: Recombinant Human COL17A1 protein(Q9UMD9)(1253-1497aa), fused to N-terminal His tag, was expressed in E. coli

Specification

• Source: E. coli
• Species: Human
• Tag: His
• Form: If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.
  If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
• Molecular Mass: 28.4 kDa
• Protein length: 1253-1497aa
• Purity: Greater than 90% as determined by SDS-PAGE.
• Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
• Reconstitution: Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. Our default final concentration of glycerol is 50%.

Gene Information

• Gene Name: COL17A1 collagen, type XVII, alpha 1 [ Homo sapiens ]
• Official Symbol: COL17A1
• Synonyms: COL17A1; collagen, type XVII, alpha 1; BPAG2; collagen alpha-1(XVII) chain; BP180; alpha 1 type XVII collagen; collagen XVII, alpha-1 polypeptide; 180 kDa bullous pemphigoid antigen 2; bullous pemphigoid antigen 2 (180kD); bA16H23.2 (collagen, type XVII, alpha 1 (BP180)); BPA-2; LAD-1; BA16H23.2; FLJ60881; KIAA0204
• Gene ID: 1308
• mRNA Refseq: NM_000494
• Protein Refseq: NP_000485
• MIM: 113811
• UniProt ID: Q9UMD9

Reviews

03/10/2022

By incorporating the COL17A1 Protein into their studies, scientists have the opportunity to conduct their research with utmost confidence, paving the way for groundbreaking discoveries and novel insights in their respective fields.

12/06/2021

Considering the aforementioned qualities, I wholeheartedly recommend the COL17A1 Protein to fellow researchers in search of a top-tier protein solution that not only meets their experimental needs but also benefits from exceptional technical support.

05/02/2016

What further sets the COL17A1 Protein apart is the outstanding technical support provided by the manufacturer.

Q&As

Are there any known interactions between COL17A1 protein and other cellular components?

COL17A1 protein interacts with integrins, laminins, and other extracellular matrix proteins to maintain skin integrity.

How does COL17A1 protein contribute to the pathogenesis of autoimmune skin diseases?

Dysregulation of COL17A1 protein can trigger autoimmunity and lead to the development of autoimmune skin diseases such as bullous pemphigoid.

What are the potential therapeutic targets related to COL17A1 protein?

Are there any known interactions between COL17A1 protein and other cellular components?

Are there any clinical implications of COL17A1 mutations beyond skin disorders?

Mutations in COL17A1 have been associated with certain forms of cancer, indicating a potential role in tumor progression and metastasis.

How is COL17A1 protein measured in a clinical setting?

COL17A1 protein levels can be measured using techniques such as western blotting, ELISA, and immunohistochemistry.