Recombinant Human DNM1L Protein (Met520-Arg736), His tagged
Cat.No. : | DNM1L-1671H |
Product Overview : | Recombinant human DRP1 (Met520-Arg736) fused with His tag was expressed in E. coli. |
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Description : | Functions in mitochondrial and peroxisomal division. Mediates membrane fission through oligomerization into membrane-associated tubular structures that wrap around the scission site to constrict and sever the mitochondrial membrane through a GTP hydrolysis-dependent mechanism. The specific recruitment at scission sites is mediated by membrane receptors like MFF, MIEF1 and MIEF2 for mitochondrial membranes. While the recruitment by the membrane receptors is GTP-dependent, the following hydrolysis of GTP induces the dissociation from the receptors and allows DNM1L filaments to curl into closed rings that are probably sufficient to sever a double membrane. Through its function in mitochondrial division, ensures the survival of at least some types of postmitotic neurons, including Purkinje cells, by suppressing oxidative damage. Required for normal brain development, including that of cerebellum. Facilitates developmentally regulated apoptosis during neural tube formation. |
Source : | E. coli |
Species : | Human |
Tag : | His |
Form : | Lyophilized powder/frozen liquid |
Molecular Mass : | 54.61 kDa |
Protein Length : | Met520-Arg736 |
Purity : | >90% as determined by SDS-PAGE |
Notes : | For research use only. |
Storage : | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8 centigrade for one week. Store at -20 to -80 centigrade for twelve months from the date of receipt. |
Storage Buffer : | Supplied as solution form in PBS, pH 7.5 or lyophilized from PBS, pH 7.5. |
Reconstitution : | Reconstitute in sterile water for a stock solution. |
Shipping : | They are shipped out with dry ice/blue ice unless customers require otherwise. |
Gene Name : | DNM1L dynamin 1-like [ Homo sapiens (human) ] |
Official Symbol : | DNM1L |
Synonyms : | DNM1L; dynamin 1-like; dynamin-1-like protein; DRP1; DVLP; DYMPLE; HDYNIV; VPS1; dynamin-like protein 4; dynamin-like protein IV; Dnm1p/Vps1p-like protein; dynamin-related protein 1; dynamin family member proline-rich carboxyl-terminal domain less; DLP1; EMPF; DYNIV-11; FLJ41912; |
Gene ID : | 10059 |
mRNA Refseq : | NM_005690 |
Protein Refseq : | NP_005681 |
MIM : | 603850 |
UniProt ID : | O00429 |
Products Types
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DNM1L-2470M | Recombinant Mouse DNM1L Protein, His (Fc)-Avi-tagged | +Inquiry |
Dnm1l-2618M | Recombinant Mouse Dnm1l Protein, Myc/DDK-tagged | +Inquiry |
◆ Lysates | ||
DNM1L-6858HCL | Recombinant Human DNM1L 293 Cell Lysate | +Inquiry |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (6)
Ask a questionA mutation in the DNM1L gene may have a genetic predisposition, meaning that the mutation is more likely to occur in a patient's family member.
DNM1L is involved in the regulation of neuronal connections and synaptic function, especially in the endocytosis and release process of synaptic vesicles, thereby affecting the transmission of neural signals.
DNM1L gene mutations can be transmitted in different genetic ways such as autosomal dominant, dominant negative, and dominant homosexual, depending on the type and location of the mutation.
DNM1L gene mutations are associated with a number of neurological-related diseases, including Charcot-Marie-Tooth disease, multiple system atrophy, intellectual disability, and movement disorders.
Mutations in the DNM1L gene may be associated with neurodegenerative diseases such as Parkinson's disease, Alzheimer's disease and Huntington's disease.
Through long-term follow-up and clinical data analysis of patients, the impact of DNM1L gene mutations on disease prognosis, such as age of onset, disease progression and quality of life, can be evaluated.
Customer Reviews (3)
Write a reviewIncrease yield and purity and improve production efficiency in biotechnology production.
Good fluorescence labeling performance in light microscopy technology, which is helpful for cell imaging studies.
In vaccine research, it has been found that it can induce immune protective effect and has potential for disease prevention.
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