Recombinant Human DNM1L Protein, Myc/DDK-tagged, C13 and N15-labeled
Cat.No. : | DNM1L-3896H |
Product Overview : | DNM1L MS Standard C13 and N15-labeled recombinant protein (NP_036192) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells. |
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Description : | This gene encodes a member of the dynamin superfamily of GTPases. The encoded protein mediates mitochondrial and peroxisomal division, and is involved in developmentally regulated apoptosis and programmed necrosis. Dysfunction of this gene is implicated in several neurological disorders, including Alzheimer's disease. Mutations in this gene are associated with the autosomal dominant disorder, encephalopathy, lethal, due to defective mitochondrial and peroxisomal fission (EMPF). Alternative splicing results in multiple transcript variants encoding different isoforms. |
Source : | HEK293 |
Species : | Human |
Tag : | Myc/DDK |
Molecular Mass : | 81.7 kDa |
AA Sequence : | MEALIPVINKLQDVFNTVGADIIQL PQIVVVGTQSSGKSSVLESLVGRDL LPRGTGIVTRRPLILQLVHVSQEDK RKTTGEENGVEAEEWGKFLHTKNKL YTDFDEIRQEIENETERISGNNKGV SPEPIHLKIFSPNVVNLTLVDLPGM TKVPVGDQPKDIELQIRELILRFIS NPNSIILAVTAANTDMATSEALKIS REVDPDGRRTLAVITKLDLMDAGTD AMDVLMGRVIPVKLGIIGVVNRSQL DINNKKSVTDSIRDEYAFLQKKYPS LANRNGTKYLARTLNRLLMHHIRDC LPELKTRINVLAAQYQSLLNSYGEP VDDKSATLLQLITKFATEYCNTIEG TAKYIETSELCGGARICYIFHETFG RTLESVDPLGGLNTIDILTAIRNAT GPRPALFVPEVSFELLVKRQIKRLE EPSLRCVELVHEEMQRIIQHCSNYS TQELLRFPKLHDAIVEVVTCLLRKR LPVTNEMVHNLVAIELAYINTKHPD FADACGLMNNNIEEQRRNRLARELP SAVSRDKSSKVPSALAPASQEPSPA ASAEADGKLIQDSRRETKNVASGGG GVGDGVQEPTTGNWRGMLKTSKAEE LLAEEKSKPIPIMPASPQKGHAVNL LDVPVPVARKLSAREQRDCEVIERL IKSYFLIVRKNIQDSVPKAVMHFLV NHVKDTLQSELVGQLYKSSLLDDLL TESEDMAQRRKEAADMLKALQGASQ IIAEIRETHLWTRTRPLEQKLISEE DLAANDILDYKDDDDKV |
Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining |
Stability : | Stable for 3 months from receipt of products under proper storage and handling conditions. |
Storage : | Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
Concentration : | 50 μg/mL as determined by BCA |
Storage Buffer : | 100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
Gene Name : | DNM1L dynamin 1-like [ Homo sapiens (human) ] |
Official Symbol : | DNM1L |
Synonyms : | DNM1L; dynamin 1-like; dynamin-1-like protein; DRP1; DVLP; DYMPLE; HDYNIV; VPS1; dynamin-like protein 4; dynamin-like protein IV; Dnm1p/Vps1p-like protein; dynamin-related protein 1; dynamin family member proline-rich carboxyl-terminal domain less; DLP1; EMPF; DYNIV-11; FLJ41912; |
Gene ID : | 10059 |
mRNA Refseq : | NM_012062 |
Protein Refseq : | NP_036192 |
MIM : | 603850 |
UniProt ID : | O00429 |
Products Types
◆ Recombinant Protein | ||
Dnm1l-2618M | Recombinant Mouse Dnm1l Protein, Myc/DDK-tagged | +Inquiry |
DNM1L-2470M | Recombinant Mouse DNM1L Protein, His (Fc)-Avi-tagged | +Inquiry |
DNM1L-2584H | Recombinant Human DNM1L Protein (1-710 aa), His-Myc-tagged | +Inquiry |
DNM1L-2785H | Recombinant Human DNM1L Protein, GST-tagged | +Inquiry |
DNM1L-1582R | Recombinant Rat DNM1L Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Lysates | ||
DNM1L-6858HCL | Recombinant Human DNM1L 293 Cell Lysate | +Inquiry |
DNM1L-6859HCL | Recombinant Human DNM1L 293 Cell Lysate | +Inquiry |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (6)
Ask a questionA mutation in the DNM1L gene may have a genetic predisposition, meaning that the mutation is more likely to occur in a patient's family member.
DNM1L is involved in the regulation of neuronal connections and synaptic function, especially in the endocytosis and release process of synaptic vesicles, thereby affecting the transmission of neural signals.
DNM1L gene mutations can be transmitted in different genetic ways such as autosomal dominant, dominant negative, and dominant homosexual, depending on the type and location of the mutation.
DNM1L gene mutations are associated with a number of neurological-related diseases, including Charcot-Marie-Tooth disease, multiple system atrophy, intellectual disability, and movement disorders.
Mutations in the DNM1L gene may be associated with neurodegenerative diseases such as Parkinson's disease, Alzheimer's disease and Huntington's disease.
Through long-term follow-up and clinical data analysis of patients, the impact of DNM1L gene mutations on disease prognosis, such as age of onset, disease progression and quality of life, can be evaluated.
Customer Reviews (3)
Write a reviewIncrease yield and purity and improve production efficiency in biotechnology production.
Good fluorescence labeling performance in light microscopy technology, which is helpful for cell imaging studies.
In vaccine research, it has been found that it can induce immune protective effect and has potential for disease prevention.
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