Recombinant Human FOXA1 protein, His-tagged

• Cat.No.: FOXA1-3739H
• Product Overview: Recombinant Human FOXA1 protein(267-399 aa), fused to His tag, was expressed in E. coli.

Specification

• Source: E. coli
• Species: Human
• Tag: His
• Form: The purified protein was Lyophilized from sterile PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH7.4). 5 % trehalose and 5 % mannitol are added as protectant before lyophilization. The elution buffer contain 300mM imidazole.
• Protein length: 267-399 aa
• AA Sequence: KCEKQPGAGGGGGSGSGGSGAKGGP ESRKDPSGASNPSADSPLHRGVHGK TGQLEGAPAPGPAASPQTLDHSGAT ATGGASELKTPASSTAPPISSGPGA LASVPASHPAHGLAPHESQLHLKGD PHYSFNHP
• Purity: 90%, by SDS-PAGE with Coomassie Brilliant Blue staining.
• Storage: Short-term storage: Store at 2-8°C for (1-2 weeks).
  Long-term storage: Aliquot and store at -20°C to -80°C for up to 3 months, buffer containing 50% glycerol is recommended for reconstitution. Avoid repeat freeze-thaw cycles.
• Reconstitution: Reconstitute at 0.25 µg/μl in 200 μl sterile water for short-term storage.
  Reconstitution with 200 μl 50% glycerol solution is recommended for longer term storage.

Gene Information

• Gene Name: FOXA1 forkhead box A1 [ Homo sapiens ]
• Official Symbol: FOXA1
• Synonyms: FOXA1; forkhead box A1; hepatocyte nuclear factor 3, alpha , HNF3A; hepatocyte nuclear factor 3-alpha; HNF-3A; TCF-3A; HNF-3-alpha; forkhead box protein A1; transcription factor 3A; hepatocyte nuclear factor 3, alpha; HNF3A; TCF3A; MGC33105
• Gene ID: 3169
• mRNA Refseq: NM_004496
• Protein Refseq: NP_004487
• MIM: 602294
• UniProt ID: P55317

Reviews

02/03/2023

The company provides a dedicated team of experts who are readily available to assist researchers throughout their experimental journey.

12/15/2022

Whether it be troubleshooting issues, offering experimental guidance, or addressing any concerns, the manufacturer's technical support ensures that researchers have a reliable and knowledgeable resource to rely on.

06/11/2017

In addition to its scientific merits, the manufacturer of FOXA1 protein stands out for its outstanding technical support.

Q&As

How does FOXA1 protein contribute to the development of liver cancer?

FOXA1 has been implicated in the development and progression of hepatocellular carcinoma, with its expression levels serving as a potential prognostic marker.

Is FOXA1 protein involved in the regulation of estrogen receptor signaling?

Yes, FOXA1 is a key co-regulator of estrogen receptor (ER) signaling, influencing the expression of ER-responsive genes and impacting the response to anti-estrogen therapies.

Can FOXA1 protein expression be used as a predictive biomarker in lung cancer?

FOXA1 expression has been associated with specific subtypes of lung cancer and may hold potential as a predictive biomarker for treatment response.

Are there any clinical trials investigating the role of FOXA1 protein in cancer treatment?

Yes, there are clinical trials focused on understanding the role of FOXA1 in cancer and exploring its potential as a therapeutic target in various cancer types.

How does FOXA1 protein influence the response to anti-androgen therapy in prostate cancer?

High FOXA1 expression has been linked to resistance to anti-androgen therapy in prostate cancer, highlighting its clinical relevance in treatment decision-making.