Recombinant Human FOXA1 Protein, His-tagged

• Cat.No.: FOXA1-24H
• Product Overview: Recombinant Human FOXA1 Protein, fused to His-tag, was expressed in E. coli.

Specification

• Description: The protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyze the reduction of hydrogen peroxide, organic hydroperoxides and lipid hydroperoxides, and thereby protect cells against oxidative damage. Several isozymes of this gene family exist in vertebrates, which vary in cellular location and substrate specificity. This isozyme has a high preference for lipid hydroperoxides and protects cells against membrane lipid peroxidation and cell death. It is also required for normal sperm development; thus, it has been identified as a 'moonlighting' protein because of its ability to serve dual functions as a peroxidase, as well as a structural protein in mature spermatozoa. Mutations in this gene are associated with Sedaghatian type of spondylometaphyseal dysplasia (SMDS). This isozyme is also a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Transcript variants resulting from alternative splicing or use of alternate promoters have been described to encode isoforms with different subcellular localization.
• Source: E. coli
• Species: Human
• Tag: His
• Form: Supplied as a 0.2 μm filtered solution in PBS, pH8.0.
• Molecular Mass: ~13.7 kDa
• AA Sequence: MGSSHHHHHHSSGLVPRGSHMDAKT FKRSYPHAKPPYSYISLITMAIQQA PSKMLTLSEIYQWIMDLFPYYRQNQ QRWQNSIRHSLSFNDCFVKVARSPD KPGKGSYWTLHPDSGNMFENGCYLR RQKRFKCEKQP
• Purity: >95%
• Storage: Store it under sterile conditions at -20 to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Concentration: 0.15 mg*7

Gene Information

• Gene Name: FOXA1 forkhead box A1 [ Homo sapiens (human) ]
• Official Symbol: FOXA1
• Synonyms: HNF3A; TCF3A
• Gene ID: 3169
• mRNA Refseq: NM_004496
• Protein Refseq: NP_004487
• MIM: 602294
• UniProt ID: P55317

Reviews

02/03/2023

The company provides a dedicated team of experts who are readily available to assist researchers throughout their experimental journey.

12/15/2022

Whether it be troubleshooting issues, offering experimental guidance, or addressing any concerns, the manufacturer's technical support ensures that researchers have a reliable and knowledgeable resource to rely on.

06/11/2017

In addition to its scientific merits, the manufacturer of FOXA1 protein stands out for its outstanding technical support.

Q&As

How does FOXA1 protein contribute to the development of liver cancer?

FOXA1 has been implicated in the development and progression of hepatocellular carcinoma, with its expression levels serving as a potential prognostic marker.

Is FOXA1 protein involved in the regulation of estrogen receptor signaling?

Yes, FOXA1 is a key co-regulator of estrogen receptor (ER) signaling, influencing the expression of ER-responsive genes and impacting the response to anti-estrogen therapies.

Can FOXA1 protein expression be used as a predictive biomarker in lung cancer?

FOXA1 expression has been associated with specific subtypes of lung cancer and may hold potential as a predictive biomarker for treatment response.

Are there any clinical trials investigating the role of FOXA1 protein in cancer treatment?

Yes, there are clinical trials focused on understanding the role of FOXA1 in cancer and exploring its potential as a therapeutic target in various cancer types.

How does FOXA1 protein influence the response to anti-androgen therapy in prostate cancer?

High FOXA1 expression has been linked to resistance to anti-androgen therapy in prostate cancer, highlighting its clinical relevance in treatment decision-making.