Recombinant Human GP1BA protein, GST-tagged

• Cat.No.: GP1BA-2983H
• Product Overview: Recombinant Human GP1BA protein(BC027955)(17-531aa), fused to N-terminal GST tag, was expressed in E. coli.

Specification

• Source: E. coli
• Species: Human
• Tag: GST
• Form: If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.
  If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
• Molecular Mass: 83.9 kDa
• Protein length: 17-531aa
• AA Sequence: HPICEVSKVASHLEVNCDKRNLTAL PPDLPKDTTILHLSENLLYTFSLAT LMPYTRLTQLNLDRCELTKLQVDGT LPVLGTLDLSHNQLQSLPLLGQTLP ALTVLDVSFNRLTSLPLGALRGLGE LQELYLKGNELKTLPPGLLTPTPKL EKLSLANNNLTELPAGLLNGLENLD TLLLQENSLYTIPKGFFGSHLLPFA FLHGNPWLCNCEILYFRRWLQDNAE NVYVWKQGVDVKAMTSNVASVQCDN SDKFPVYKYPGKGCPTLGDEGDTDL YDYYPEEDTEGDKVRATRTVVKFPT KAHTTPWGLFYSWSTASLDSQMPSS LHPTQESTKEQTTFPPRWTPNFTLH MESITFSKTPKSTTEPTPSPTTSEP VPEPAPNMTTLEPTPSPTTPEPTSE PAPSPTTPEPTPIPTIATSPTILVS ATSLITPKSTFLTTTKPVSLLESTK KTIPELDQPPKLRGVLQGHLESSRN DPFLHPDFCCLLPLGFYVLGLFWLL FASVVLILLLSWVGH
• Purity: Greater than 85% as determined by SDS-PAGE.
• Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
• Reconstitution: Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. Our default final concentration of glycerol is 50%.

Gene Information

• Gene Name: GP1BA glycoprotein Ib (platelet), alpha polypeptide [ Homo sapiens ]
• Official Symbol: GP1BA
• Synonyms: GP1BA; glycoprotein Ib (platelet), alpha polypeptide; GP1B; platelet glycoprotein Ib alpha chain; CD42b; GP-Ib alpha; antigen CD42b-alpha; platelet membrane glycoprotein 1b-alpha subunit; BSS; VWDP; CD42B; GPIbA; BDPLT1; BDPLT3; DBPLT3; CD42b-alpha; MGC34595
• Gene ID: 2811
• mRNA Refseq: NM_000173
• Protein Refseq: NP_000164
• MIM: 606672
• UniProt ID: P07359

Reviews

11/04/2022

Its compatibility with collaborative platforms and open-source tools facilitated sharing and reproducibility of our experiments.

04/12/2022

The product's support in the form of educational resources positively impacted the learning curve for our researchers.

06/24/2016

The product's track record of being featured in influential publications positively influenced our decision to use it.

Q&As

What is the primary function of Glycoprotein Ib platelet subunit alpha (GP1BA) in platelet physiology and hemostasis?

Glycoprotein Ib platelet subunit alpha (GP1BA) plays a crucial role in platelet physiology and hemostasis, specifically in platelet adhesion.

What diseases or conditions are associated with dysregulation or abnormal expression of GP1BA?

Dysregulation or abnormal expression of GP1BA is associated with conditions such as Bernard-Soulier syndrome and other platelet disorders.

How does GP1BA contribute to platelet adhesion and the formation of platelet plugs at sites of vascular injury?

GP1BA contributes to platelet adhesion by interacting with von Willebrand factor (vWF), facilitating platelet plug formation at vascular injury sites.

What are the interactions or binding partners of GP1BA, and how do they influence platelet function?

Interactions or binding partners of GP1BA include vWF and other components of the platelet glycoprotein Ib-IX-V complex, influencing platelet function.

How does GP1BA participate in the regulation of blood clotting and coagulation cascades?

GP1BA participates in the regulation of blood clotting and coagulation cascades by initiating platelet activation and aggregation.

In which cellular compartments is GP1BA predominantly localized, especially within platelets?

GP1BA is predominantly localized on the surface of platelets, especially within the platelet membrane.

Are there therapeutic implications or potential targets related to GP1BA in diseases involving platelet disorders?

There are potential therapeutic implications related to GP1BA in diseases involving platelet disorders, making it a target for drug development.