Recombinant Human GP1BA protein, His-tagged

• Cat.No.: GP1BA-1832H
• Product Overview: Recombinant Human GP1BA aa. (Leu136~Pro276 (Accession # P07359)) fused with N-terminal His tag was produced in E. coli cells.

Specification

• Source: E. coli
• Species: Human
• Tag: His
• Form: Freeze-dried powder
• Molecular Mass: Predicted Molecular Mass: 17.4kDa
• Protein length: Leu136~Pro276 (Accession # P07359)
• Endotoxin: <1.0EU per 1ug (determined by the LAL method)
• Purity: >95%
• Characteristic: The isoelectric point is 6.2.
• Applications: SDS-PAGE; WB; ELISA; IP.
• Stability: The thermal stability is described by the loss rate of the target protein. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. (Referring from China Biological Products Standard, which was calculated by the Arrhenius equation.) The loss of this protein is less than 5% within the expiration date under appropriate storage condition.
• Storage: Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months.
• Storage buffer: Supplied as lyophilized form in PBS, pH8.0, containing 5% sucrose, 0.02% sarcosyl.
• Reconstitution: Reconstitute in sterile PBS.

Gene Information

• Gene Name: GP1BA glycoprotein Ib platelet alpha subunit [ Homo sapiens (human) ]
• Official Symbol: GP1BA
• Synonyms: GP1BA; glycoprotein Ib platelet alpha subunit; BSS; GP1B; VWDP; CD42B; GPIbA; BDPLT1; BDPLT3; DBPLT3; GPIbalpha; CD42b-alpha; platelet glycoprotein Ib alpha chain; GP-Ib alpha; antigen CD42b-alpha; glycoprotein Ib (platelet), alpha polypeptide; mutant platelet membrane glycoprotein Ib-alpha; platelet membrane glycoprotein 1b-alpha subunit; platelet membrane glycoprotein Ib-alpha
• Gene ID: 2811
• mRNA Refseq: NM_000173.6
• Protein Refseq: NP_000164.5
• UniProt ID: P07359

Reviews

11/04/2022

Its compatibility with collaborative platforms and open-source tools facilitated sharing and reproducibility of our experiments.

04/12/2022

The product's support in the form of educational resources positively impacted the learning curve for our researchers.

06/24/2016

The product's track record of being featured in influential publications positively influenced our decision to use it.

Q&As

What is the primary function of Glycoprotein Ib platelet subunit alpha (GP1BA) in platelet physiology and hemostasis?

Glycoprotein Ib platelet subunit alpha (GP1BA) plays a crucial role in platelet physiology and hemostasis, specifically in platelet adhesion.

What diseases or conditions are associated with dysregulation or abnormal expression of GP1BA?

Dysregulation or abnormal expression of GP1BA is associated with conditions such as Bernard-Soulier syndrome and other platelet disorders.

How does GP1BA contribute to platelet adhesion and the formation of platelet plugs at sites of vascular injury?

GP1BA contributes to platelet adhesion by interacting with von Willebrand factor (vWF), facilitating platelet plug formation at vascular injury sites.

What are the interactions or binding partners of GP1BA, and how do they influence platelet function?

Interactions or binding partners of GP1BA include vWF and other components of the platelet glycoprotein Ib-IX-V complex, influencing platelet function.

How does GP1BA participate in the regulation of blood clotting and coagulation cascades?

GP1BA participates in the regulation of blood clotting and coagulation cascades by initiating platelet activation and aggregation.

In which cellular compartments is GP1BA predominantly localized, especially within platelets?

GP1BA is predominantly localized on the surface of platelets, especially within the platelet membrane.

Are there therapeutic implications or potential targets related to GP1BA in diseases involving platelet disorders?

There are potential therapeutic implications related to GP1BA in diseases involving platelet disorders, making it a target for drug development.