Recombinant Human IL18R1 protein(Ala19-Arg329), hFc-tagged
Cat.No. : | IL18R1-165H |
Product Overview : | Recombinant Human IL18R1 protein(Ala19-Arg329)(AAH69575.1) is expressed from HEK293 with hFc tag at the C-terminus. |
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Source : | HEK293 |
Species : | Human |
Tag : | C-hFc |
Protein length : | Ala19-Arg329 |
Form : | Lyophilized from 0.22 μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. |
Bio-activity : | Human IL-18 R1, hFc Tag captured on CM5 Chip via Protein A can bind Human IL-18, No Tag with an affinity constant of 0.73 nM as determined in SPR assay (Biacore T200). |
Molecular Mass : | The protein has a predicted MW of 62.52 kDa. Due to glycosylation, the protein migrates to 75-95 kDa based on Tris-Bis PAGE result. |
Endotoxin : | Less than 1EU per μg by the LAL method. |
Purity : | > 95% as determined by Tris-Bis PAGE > 95% as determined by HPLC |
Storage : | -20 to -80°C for 12 months as supplied from date of receipt. -80°C for 3-6 months after reconstitution. 2-8°C for 2-7 days after reconstitution. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
Reconstitution : | Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water. |
Gene Name : | IL18R1 interleukin 18 receptor 1 [ Homo sapiens ] |
Official Symbol : | IL18R1 |
Synonyms : | IL18R1; interleukin 18 receptor 1; interleukin-18 receptor 1; CD218a; IL 1Rrp; IL1RRP; IL-18R1; IL1R-rp; IL-18R-1; cytokine receptor; IL1 receptor-related protein; CD218 antigen-like family member A; IL18RA; CDw218a; IL-1Rrp; |
Gene ID : | 8809 |
mRNA Refseq : | NM_003855 |
Protein Refseq : | NP_003846 |
MIM : | 604494 |
UniProt ID : | Q13478 |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (10)
Ask a questionCo-immunoprecipitation, co-receptor binding assays, and functional studies unveil the cooperative roles of IL18R1 and IL18RAP in signaling.
Fluorescence microscopy, confocal imaging, and super-resolution microscopy visualize IL18R1 dynamics and clustering upon IL18 stimulation.
Mass spectrometry, phosphorylation assays, and ubiquitination studies investigate IL18R1 post-translational modifications.
Disease model assessments, patient sample analyses, and pharmacological interventions explore IL18R1's involvement in diseases and therapeutic potential.
RT-qPCR, flow cytometry, and single-cell RNA sequencing assess IL18R1 expression across different cell types and physiological states.
Knockout models, siRNA-mediated knockdown, and CRISPR/Cas9 gene editing reveal the physiological roles of IL18R1 in vivo and in vitro.
Western blotting, ELISAs, and phosphoprotein analyses decipher IL18R1-mediated signaling cascades and cytokine production.
Site-directed mutagenesis, chimera studies, and domain swapping experiments dissect the functional contributions of IL18R1's domains.
X-ray crystallography, cryo-electron microscopy, and molecular dynamics simulations elucidate the structural basis of IL18R1-IL18 recognition and activation.
Surface plasmon resonance, bio-layer interferometry, and kinetic binding assays quantify IL18R1-IL18 interactions.
Customer Reviews (3)
Write a reviewLow endotoxin levels.
Good for flow cytometry.
Potent in Th1 activation.
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