Recombinant Human Interleukin 17A, Fc Chimera
Cat.No. : | IL17A-279H |
Product Overview : | Recombinant Human Interleukin 17A is produced in mammalian cells andfused with human IgG1Fc. IL-17A (C-terminus fused with human IgG1Fc) contains 361 amino acids with predicted MW 40.82kDa x 2 (dimmer) and 12 cysteines (Fc has 6). It also has 1 N-link glycosylation site with MW increase up to 5 kDa. Receptor for IL-17A induces stromal cells to produce proinflamatory and hematopoietic cytokins. Enhances the surface expression of the intracellular adhesion molecule-1 (ICAM-1) in fibroblasts. |
- Specification
- Gene Information
- Related Products
Cat. No. : | IL17A-279H |
Description : | The protein encoded by this gene is a proinflammatory cytokine produced by activated T cells. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis. |
Source : | Mammalian cells. |
Purity : | >90%. |
Quantity : | 2.0mg/2ml PBS. |
Availability : | Back order, one month for production. |
Storage : | -70°C |
Gene Name : | 17A interleukin 17A [ Homo sapiens ] |
Synonyms : | IL17A; interleukin 17A; IL17; CTLA8; IL-17; IL-17A; toxic T-lymphocyte-associated antigen 8; otoxic T-lymphocyte-associated protein 8; cytotoxic T-lymphocyte-associated serine esterase 8; interleukin 17 (cytotoxic T-lymphocyte-associated serine esterase 8) |
Gene ID : | 3605 |
mRNA Refseq : | NM_002190 |
Protein Refseq : | NP_002181 |
MIM : | 603149 |
UniProt ID : | Q16552 |
Chromosome Location : | 6p12 |
Pathway : | Cytokine-cytokine receptor interaction |
Function : | cytokine activity |
Products Types
◆ Recombinant Protein | ||
IL17A-168C | Active Recombinant Canine IL17A protein(Gly26-Ala155) | +Inquiry |
IL17A-100I | Active Recombinant Human IL17A Protein (136 aa) | +Inquiry |
IL17A-15P | Recombinant Pig IL17A Protein (Gly26-Ser155), C-His tagged, Animal-free, Carrier-free | +Inquiry |
IL17A-254I | Active Recombinant Human IL17A Protein (142 aa), His-tagged | +Inquiry |
IL17A-508M | Recombinant Mouse IL17A Protein | +Inquiry |
◆ Lysates | ||
IL17A-001HCL | Recombinant Human IL17A cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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