Recombinant Human NCR2, His-tagged

• Cat.No.: NCR2-5003H
• Product Overview: Recombinant human NKP44 protein, fused to His-tag at N-terminus, was expressed in E.coli.

Specification

• Description: NCR2 belongs to the natural cytotoxicity receptor (NCR) family and contains 1 Ig-like (immunoglobulin-like) domain. This protein interacts with TYROBP/DAP12 and is selectively expressed by activated NK cells and by in vitro cultured (i.e. activated) TCRg/d lymphoid cells. NCR2 is a cytotoxicity-activating receptor that may contribute to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis.
• Source: E. coli
• Species: Human
• Tag: His
• Form: Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 10% glycerol, 0.4M Urea
• Molecular Mass: 15.0 kDa (133aa)
• AA Sequence: MGSSHHHHHH SSGLVPRGSH MSQAQSKAQV LQSVAGQTLT VRCQYPPTGS LYEKKGWCKE ASALVCIRLV TSSKPRTMAW TSRFTIWDDP DAGFFTVTMT DLREEDSGHY WCRIYRPSDN SVSKSVRFYL VVS
• Purity: >80 % by SDS - PAGE
• Applications: SDS-PAGE
• Storage: Can be stored at +4centigrade short term (1-2 weeks). For long term storage, aliquot and store at -20centigrade or -70centigrade. Avoid repeated freezing and thawing cycles.
• Concentration: 1.0 mg/ml (determined by Bradford assay)

Gene Information

• Gene Name: NCR2 natural cytotoxicity triggering receptor 2 [ Homo sapiens ]
• Official Symbol: NCR2
• Synonyms: NCR2; natural cytotoxicity triggering receptor 2; LY95, lymphocyte antigen 95 (activating NK receptor; NK p44); CD336; NK p44; NK cell-activating receptor; NK cell activating receptor (NKp44); natural killer cell p44-related protein; lymphocyte antigen 95 (activating NK-receptor; NK-p44); lymphocyte antigen 95 homolog (activating NK-receptor; LY95; NKP44; NK-p44; dJ149M18.1
• Gene ID: 9436
• mRNA Refseq: NM_001199509
• Protein Refseq: NP_001186438
• MIM: 604531
• UniProt ID: O95944
• Chromosome Location: 6p21.1
• Pathway: Natural killer cell mediated cytotoxicity, organism-specific biosystem; Natural killer cell mediated cytotoxicity, conserved biosystem
• Function: receptor activity; transmembrane signaling receptor activity

Reviews

01/27/2023

The NCR2 proteins purchased from your company is suitable for ELISA.

08/12/2022

The technical expert communicated with me in time to understand the progress of my experiment and gave me suggestions for improvement.

07/20/2022

The high quality of the purchased protein helped me to obtain satisfactory experimental results.

Q&As

Where NCR2 is expressed?

NCR2 is only expressed on the surface of activated natural killer (NK) cells.

What is the relationship between NCR2 and DAP12?

NCR2 interacts with DAP12.

What function does NCR2 have?

NCR2 proteins function as cytotoxic activation receptors that enhance the efficiency of activated natural killer (NK) cells to mediate tumor cell lysis.