Recombinant Human NCR2 Protein, C-His-tagged

• Cat.No.: NCR2-188H
• Product Overview: Recombinant Human NCR2 Protein with C-His tag was expressed in E. coli.

Specification

• Description: Natural killer (NK) cells direct cytotoxicity against tumor or virally infected cells. NK cell-mediated cytotoxicity is stimulated by several activating receptors associated with the signaling adapter DNAX activation 12/killer cellactivating receptor-associated protein (DAP12). NKp44 is a natural cytotoxicity receptor that is expressed on IL-2-activated human NK cells and may contribute to the increased efficiency of NK cells to mediate tumor cell lysis. NKp44 is composed of one Ig-like extracellular domain, a transmembrane segment and a cytoplasmic domain. Prolactin upregulates and cortisol downregulates the surface expression of NKp44 at the transcriptional level. A cellular ligand for NKp44 (NKp44L) is expressed during HIV-1 infection and is correlated with the progression of CD4+ T cell depletion and an increase of viral load. This implicates NKp44 as a therapeutic agent that may aid in the progress towards a vaccine for HIV-1 infection.
• Source: E. coli
• Species: Human
• Tag: C-His
• Molecular Mass: ~19 kDa
• AA Sequence: QSKAQVLQSVAGQTLTVRCQYPPTG SLYEKKGWCKEASALVCIRLVTSSK PRTMAWTSRFTIWDDPDAGFFTVTM TDLREEDSGHYWCRIYRPSDNSVSK SVRFYLVVSPASASTQTSWTPRDLV SSQTQTQSCVPPTAGARQAPESPST IPVPSQPQNSTLRPGPAAPIA
• Purity: Transferred into competent cells and the supernatant was purified by NI column affinity chromatography and the purity is > 85% (by SDS-PAGE).
• Notes: For research use only, not for use in diagnostic procedure.
• Storage: Store at 4 centigrade short term. Aliquot and store at -20 centigrade long term. Avoid freeze-thaw cycles.
• Concentration: ≥0.5 mg/mL
• Storage Buffer: PBS, 4M Urea, pH7.4

Gene Information

• Gene Name: NCR2 natural cytotoxicity triggering receptor 2 [ Homo sapiens (human) ]
• Official Symbol: NCR2
• Synonyms: NCR2; natural cytotoxicity triggering receptor 2; LY95, lymphocyte antigen 95 (activating NK receptor; NK p44); CD336; NK p44; NK cell-activating receptor; NK cell activating receptor (NKp44); natural killer cell p44-related protein; lymphocyte antigen 95 (activating NK-receptor; NK-p44); lymphocyte antigen 95 homolog (activating NK-receptor; LY95; NKP44; NK-p44; dJ149M18.1
• Gene ID: 9436
• mRNA Refseq: NM_001199509
• Protein Refseq: NP_001186438
• MIM: 604531
• UniProt ID: O95944

Reviews

01/27/2023

The NCR2 proteins purchased from your company is suitable for ELISA.

08/12/2022

The technical expert communicated with me in time to understand the progress of my experiment and gave me suggestions for improvement.

07/20/2022

The high quality of the purchased protein helped me to obtain satisfactory experimental results.

Q&As

Where NCR2 is expressed?

NCR2 is only expressed on the surface of activated natural killer (NK) cells.

What is the relationship between NCR2 and DAP12?

NCR2 interacts with DAP12.

What function does NCR2 have?

NCR2 proteins function as cytotoxic activation receptors that enhance the efficiency of activated natural killer (NK) cells to mediate tumor cell lysis.