Recombinant Human ROBO1

• Cat.No.: ROBO1-30953TH
• Product Overview: Recombinant fragment, corresponding to amino acids 491-589 of Human Robo1, with an N-terminal proprietary tag, predicted MWt 36.52 kDa

Specification

• Description: Bilateral symmetric nervous systems have special midline structures that establish a partition between the two mirror image halves. Some axons project toward and across the midline in response to long-range chemoattractants emanating from the midline. The product of this gene is a member of the immunoglobulin gene superfamily and encodes an integral membrane protein that functions in axon guidance and neuronal precursor cell migration. This receptor is activated by SLIT-family proteins, resulting in a repulsive effect on glioma cell guidance in the developing brain. A related gene is located at an adjacent region on chromosome 3. Multiple transcript variants encoding different isoforms have been found for this gene.
• Protein length: 99 amino acids
• Molecular Weight: 36.520kDa inclusive of tags
• Source: Wheat germ
• Tissue specificity: Widely expressed, with exception of kidney.
• Form: Liquid
• Purity: Proprietary Purification
• Storage buffer: pH: 8.00Constituents:0.3% Glutathione, 0.79% Tris HCl
• Storage: Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
• Sequences of amino acids: DGVLVSTQDSRIKQLENGVLQIRYA KLGDTGRYTCIASTPSGEATWSAYI EVQEFGVPVQPPRPTDPNLIPSAPS KPEVTDVSRNTVTLSWQPNLNSGA
• Sequence Similarities: Belongs to the immunoglobulin superfamily. ROBO family.Contains 3 fibronectin type-III domains.Contains 5 Ig-like C2-type (immunoglobulin-like) domains.

Gene Information

• Gene Name: ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) [ Homo sapiens ]
• Official Symbol: ROBO1
• Synonyms: ROBO1; roundabout, axon guidance receptor, homolog 1 (Drosophila); roundabout (axon guidance receptor, Drosophila) homolog 1; roundabout homolog 1; DUTT1; FLJ21882; SAX3
• Gene ID: 6091
• mRNA Refseq: NM_001145845
• Protein Refseq: NP_001139317
• MIM: 602430
• Uniprot ID: Q9Y6N7
• Chromosome Location: 3p12.3
• Pathway: Activation of Rac, organism-specific biosystem; Axon guidance, organism-specific biosystem; Axon guidance, conserved biosystem; Axon guidance, organism-specific biosystem; Developmental Biology, organism-specific biosystem
• Function: LRR domain binding; axon guidance receptor activity; identical protein binding; protein binding; receptor activity

Reviews

06/28/2023

ROBO1 is able to maintain its biological activity and structural integrity under specific experimental conditions.

06/07/2022

ROBO1 products have low endotoxin levels and do not interfere with experimental results.

07/31/2021

When using ROBO1 for experiments, you can get a clear and reliable interpretation of your results.

Q&As

What is the association between ROBO1 recombinant protein and tumors?

Some studies have shown that ROBO1 recombinant protein may be involved in the initiation and progression of tumors, especially in neurological tumors.

Does ROBO1 recombinant protein function in pregnant women?

The level of ROBO1 recombinant protein in pregnant women may change due to the needs of fetal growth and development, and regular monitoring is required.

Does ROBO1 have a function in the human body?

ROBO1 is mainly involved in axon guidance and neural network formation in the human body, affecting the development and function of the nervous system.

If the level of ROBO1 recombinant protein is abnormal, what should I do?

If the level of ROBO1 recombinant protein is abnormal, treatment may include the use of drugs or other special treatments, depending on the condition and the doctor's recommendation.

Is there a treatment for ROBO1 recombinant proteins?

The current treatments for ROBO1 recombinant protein mainly include gene therapy, protein replacement therapy, and drug therapy for axon guidance.

What is the association between ROBO1 recombinant protein and neurological diseases?

ROBO1 recombinant protein may be involved in the occurrence and progression of neurological diseases, especially in glioma, neural tube defects, and autism.