Recombinant Human RPE65, His-tagged
Cat.No. : | RPE65-2371H |
Product Overview : | Recombinant Human RPE65 protein, fused to His-tag, was expressed in E.coli and purified by Ni-sepharose. |
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Source : | E.coli |
Species : | Human |
Tag : | His |
Protein length : | 204-533aa |
Storage : | The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles. |
Storage Buffer : | 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 300mM Imidazole and 0.7% Sarcosyl, 15%glycerol. |
Gene Name : | RPE65 retinal pigment epithelium-specific protein 65kDa [ Homo sapiens ] |
Official Symbol : | RPE65 |
Synonyms : | RPE65; retinal pigment epithelium-specific protein 65kDa; retinal pigment epithelium specific protein (65kD) , RP20; retinoid isomerohydrolase; all trans retinyl palmitate hydrolase; LCA2; rd12; retinol isomerase; p63; RBP-binding membrane protein; all-trans-retinyl-palmitate hydrolase; retinitis pigmentosa 20 (autosomal recessive); retinal pigment epithelium-specific 65 kDa protein; RP20; mRPE65; sRPE65; |
Gene ID : | 6121 |
mRNA Refseq : | NM_000329 |
Protein Refseq : | NP_000320 |
MIM : | 180069 |
UniProt ID : | Q16518 |
Chromosome Location : | 1p31 |
Pathway : | Retinol metabolism, organism-specific biosystem; Retinol metabolism, conserved biosystem; Visual signal transduction: Cones, organism-specific biosystem; Visual signal transduction: Rods, organism-specific biosystem; Vitamin A and carotenoid metabolism, organism-specific biosystem; the visual cycle, conserved biosystem; the visual cycle, organism-specific biosystem; |
Function : | all-trans-retinyl-palmitate hydrolase activity; hydrolase activity; isomerase activity; metal ion binding; |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (7)
Ask a questionGene therapy targeting RPE65 shows promise in treating inherited retinal dystrophies, restoring some visual functions.
RPE65 facilitates the conversion of vitamin A derivatives, essential for the regeneration of visual pigments.
Mutations in RPE65 impact visual acuity and night vision, leading to difficulties in low-light conditions.
Changes in RPE65 may contribute to the progression of age-related macular degeneration, affecting central vision.
RPE65 is involved in the regeneration of photoreceptors and visual pigments, key for maintaining healthy vision.
RPE65 is crucial in the visual cycle, converting vitamin A derivatives necessary for retinal function and vision.
RPE65 deficiency leads to retinal diseases by disrupting the visual cycle, affecting vision from an early age.
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