Recombinant Human RSPO3 protein, His & T7-tagged
Cat.No. : | RSPO3-1946H |
Product Overview : | Recombinant Human RSPO3 aa. (Gln22~His272 (Accession # Q9BXY4)) fused with N-terminal His & T7 tag was produced in E. coli cells. |
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Description : | This gene belongs to the R-spondin family. The encoded protein plays a role in the regulation of Wnt (wingless-type MMTV integration site family)/beta-catenin and Wnt/planar cell polarity (PCP) signaling pathways, which are involved in development, cell growth and disease pathogenesis. Genome-wide association studies suggest a correlation of this gene with bone mineral density and risk of fracture. This gene may be involved in tumor development. |
Source : | E. coli |
Species : | Human |
Tag : | His & T7 |
Form : | Freeze-dried powder |
Molecular Mass : | Predicted Molecular Mass: 32.0kDa |
Protein length : | Gln22~His272 (Accession # Q9BXY4) |
Endotoxin : | <1.0EU per 1ug (determined by the LAL method) |
Purity : | >95% |
Applications : | SDS-PAGE; WB; ELISA; IP. |
Stability : | The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition. |
Storage : | Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months. |
Storage buffer : | Supplied as lyophilized form in PBS, pH7.4, containing 5% trehalose, 0.01% sarcosyl. |
Reconstitution : | Reconstitute in sterile PBS, pH7.2-pH7.4. |
Isoelectric Point : | 9.5 |
Gene Name : | RSPO3 R-spondin 3 [ Homo sapiens (human) ] |
Official Symbol : | RSPO3 |
Synonyms : | RSPO3; R-spondin 3; PWTSR; THSD2; CRISTIN1; R-spondin-3; R-spondin 3 homolog; protein with TSP type-1 repeat; roof plate-specific spondin-3; thrombospondin type-1 domain-containing protein 2; thrombospondin, type I, domain containing 2 |
Gene ID : | 84870 |
mRNA Refseq : | NM_032784.4 |
Protein Refseq : | NP_116173.2 |
UniProt ID : | Q9BXY4 |
Products Types
◆ Recombinant Protein | ||
RSPO3-35H | Recombinant Human RSPO3 Protein | +Inquiry |
RSPO3-423H | Recombinant Human RSPO3 Protein, His-tagged | +Inquiry |
RSPO3-14554M | Active Recombinant Mouse RSPO3 Protein | +Inquiry |
RSPO3-2455H | Recombinant Human RSPO3, GST-tagged | +Inquiry |
RSPO3-2315Z | Recombinant Zebrafish RSPO3 | +Inquiry |
◆ Lysates | ||
RSPO3-1906HCL | Recombinant Human RSPO3 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (7)
Ask a questionGenetic mutations in RSPO3 can disrupt normal development and tissue regeneration.
Targeting RSPO3 could offer advances in regenerative medicine and cancer therapy by modulating Wnt signaling.
RSPO3 plays a significant role in maintaining stem cell populations and influencing their differentiation.
It stimulates tissue development and regeneration by activating Wnt pathways, essential for cellular proliferation.
RSPO3, a member of the R-spondin family, enhances Wnt signaling, crucial for cellular growth and differentiation.
Altered RSPO3 activity is linked to cancer development and progression, particularly in colorectal cancer.
RSPO3 interacts synergistically with Wnt pathway components, amplifying signal transduction.
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