Recombinant Human SOD3

• Cat.No.: SOD3-31476TH
• Product Overview: Recombinant fragment, corresponding to amino acids 26-125 of Human Superoxide Dismutase 3, with an N-terminal proprietary tag, predicted MWt 36.63 kDa

Specification

• Description: This gene encodes a member of the superoxide dismutase (SOD) protein family. SODs are antioxidant enzymes that catalyze the dismutation of two superoxide radicals into hydrogen peroxide and oxygen. The product of this gene is thought to protect the brain, lungs, and other tissues from oxidative stress. The protein is secreted into the extracellular space and forms a glycosylated homotetramer that is anchored to the extracellular matrix (ECM) and cell surfaces through an interaction with heparan sulfate proteoglycan and collagen. A fraction of the protein is cleaved near the C-terminus before secretion to generate circulating tetramers that do not interact with the ECM.
• Protein length: 100 amino acids
• Molecular Weight: 36.630kDa inclusive of tags
• Source: Wheat germ
• Tissue specificity: Expressed in blood vessels, heart, lung, kidney and placenta. Major SOD isoenzyme in extracellular fluids such as plasma, lymph and synovial fluid.
• Form: Liquid
• Purity: Proprietary Purification
• Storage buffer: pH: 8.00Constituents:0.3% Glutathione, 0.79% Tris HCl
• Storage: Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
• Sequences of amino acids: EPNSDSAEWIRDMYAKVTEIWQEVM QRRDDDGTLHAACQVQPSATLDAAQ PRVTGVVLFRQLAPRAKLDAFFALE GFPTEPNSSSRAIHVHQFGDLSQGC
• Sequence Similarities: Belongs to the Cu-Zn superoxide dismutase family.

Gene Information

• Gene Name: SOD3 superoxide dismutase 3, extracellular [ Homo sapiens ]
• Official Symbol: SOD3
• Synonyms: SOD3; superoxide dismutase 3, extracellular; extracellular superoxide dismutase [Cu-Zn]; EC SOD
• Gene ID: 6649
• mRNA Refseq: NM_003102
• Protein Refseq: NP_003093
• MIM: 185490
• Uniprot ID: P08294
• Chromosome Location: 4pter-q21
• Pathway: Folate Metabolism, organism-specific biosystem; Oxidative Stress, organism-specific biosystem; Selenium Pathway, organism-specific biosystem
• Function: copper ion binding; heparin binding; metal ion binding; oxidoreductase activity; protein binding

Reviews

02/19/2023

Trusted for results accuracy. A research necessity.

06/22/2017

Efficient and dependable. Accelerates our research progress.

06/12/2017

Enhances research credibility. Consistent and trustworthy.

Q&As

What potential therapeutic applications arise from targeting SOD3 in oxidative stress-related conditions?

Enhancing SOD3 activity could be a therapeutic strategy in treating oxidative stress-related diseases.

How do genetic variations in SOD3 affect its antioxidant function?

Genetic mutations in SOD3 can impair its ability to scavenge free radicals, affecting its protective role.

How does SOD3 contribute to cellular protection against free radicals?

It protects cells from oxidative damage by converting free radicals to less harmful substances.

What is the impact of altered SOD3 activity on aging and age-related diseases?

Altered SOD3 activity is linked with accelerated aging and the development of age-related diseases.

How does SOD3 interact with other cellular antioxidants?

SOD3 works alongside other antioxidants, contributing to the overall oxidative defense system.

What is the primary role of SOD3 in oxidative stress management?

SOD3, a type of superoxide dismutase, is crucial for neutralizing superoxide radicals, reducing oxidative stress.

What role does SOD3 play in cardiovascular health?

SOD3 is important for cardiovascular health, preventing oxidative damage in blood vessels.