Recombinant Human SOD3 protein, GST-tagged

• Cat.No.: SOD3-203H
• Product Overview: Recombinant Human SOD3 fused with GST tag at N-terminal was expressed in Insect cells.

Specification

• Description: Extracellular superoxide dismutase [Cu-Zn] (SOD3) protects the extracellular space from toxic effect of reactive oxygen intermediates by converting superoxide radicals into hydrogen peroxide and oxygen. Although the function of SOD3 as a regulator of cellular growth has been well established, the role of SOD3 in tumorigenesis is still unclear.
• Source: Insect cells
• Species: Human
• Tag: GST
• Form: 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
• Molecular Mass: 52 kDa
• Endotoxin: <1.0 EU/μg of recombinant protein as determined by the LAL method.
• Purity: >70%
• Applications: Western Blot
• Stability: 1 year at -70 centigrade from the date of shipment.
• Storage: The lyophilized protein is stable for at least one year from date of receipt at -70 centigrade. Upon reconstitution, this cytokine can be stored in working aliquots at 2 centigrade- 8 centigrade for one month, or at -20 centigrade for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles.
• Concentration: 0.05μg/μl

Gene Information

• Gene Name: SOD3 superoxide dismutase 3, extracellular [ Homo sapiens ]
• Official Symbol: SOD3
• Synonyms: SOD3; superoxide dismutase 3, extracellular; extracellular superoxide dismutase [Cu-Zn]; EC SOD; EC-SOD; MGC20077
• Gene ID: 6649
• mRNA Refseq: NM_003102
• Protein Refseq: NP_003093
• MIM: 185490
• UniProt ID: P08294
• Chromosome Location: 4pter-q21
• Pathway: Folate Metabolism, organism-specific biosystem; Oxidative Stress, organism-specific biosystem; Selenium Pathway, organism-specific biosystem; superoxide radicals degradation, organism-specific biosystem
• Function: copper ion binding; heparin binding; metal ion binding; oxidoreductase activity; protein binding; superoxide dismutase activity; zinc ion binding

Reviews

02/19/2023

Trusted for results accuracy. A research necessity.

06/22/2017

Efficient and dependable. Accelerates our research progress.

06/12/2017

Enhances research credibility. Consistent and trustworthy.

Q&As

What potential therapeutic applications arise from targeting SOD3 in oxidative stress-related conditions?

Enhancing SOD3 activity could be a therapeutic strategy in treating oxidative stress-related diseases.

How do genetic variations in SOD3 affect its antioxidant function?

Genetic mutations in SOD3 can impair its ability to scavenge free radicals, affecting its protective role.

How does SOD3 contribute to cellular protection against free radicals?

It protects cells from oxidative damage by converting free radicals to less harmful substances.

What is the impact of altered SOD3 activity on aging and age-related diseases?

Altered SOD3 activity is linked with accelerated aging and the development of age-related diseases.

How does SOD3 interact with other cellular antioxidants?

SOD3 works alongside other antioxidants, contributing to the overall oxidative defense system.

What is the primary role of SOD3 in oxidative stress management?

SOD3, a type of superoxide dismutase, is crucial for neutralizing superoxide radicals, reducing oxidative stress.

What role does SOD3 play in cardiovascular health?

SOD3 is important for cardiovascular health, preventing oxidative damage in blood vessels.