Recombinant Mouse Abce1, His-tagged
Cat.No. : | Abce1-3741M |
Product Overview : | ATP-binding cassette sub-family E member 1 (Abce1) |
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Description : | The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the OABP subfamily. Alternatively referred to as the RNase L inhibitor, this protein functions to block the activity of ribonuclease L. Activation of ribonuclease L leads to inhibition of protein synthesis in the 2-5A/RNase L system, the central pathway for viral interferon action. |
Source : | E. Coli or Yeast |
Species : | Mouse |
Tag : | His |
Form : | This item requires custom production and lead time is between 5-9 weeks. We can custom produce according to your specifications. |
Protein length : | 599 |
Purity : | >90% |
Notes : | Small volumes of Abce1 recombinant protein may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice. |
Storage : | Store at -20 degree C. For extended storage, store at -20 or -80 degree C. |
Storage Buffer : | PBS pH 7.4, 50% glycerol |
Warning : | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Gene Name : | Abce1 |
Official Symbol : | Abce1 |
Synonyms : | Abce1; Rli ; Abce1; Abce1; RLI; Oabp; RN... |
Gene ID : | 24015 |
mRNA Refseq : | NM_015751.2 |
Protein Refseq : | NP_056566.2 |
UniProt ID : | P61222 |
Chromosome Location : | Chromosome: 8; NC_000074.6 (79683442..79711740, complement). Location: 8 C; 8 |
Function : | The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the OABP subfamily. Alternatively referred to as the RNase L inhibitor, this protein functions to block the activity of ribonuclease L. Activation of ribonuclease L leads to inhibition of protein synthesis in the 2-5A/RNase L system, the central pathway for viral interferon action. |
Products Types
◆ Recombinant Protein | ||
Abce1-1462M | Recombinant Mouse Abce1 Protein, Myc/DDK-tagged | +Inquiry |
ABCE1-245H | Recombinant Human ABCE1 Protein, His (Fc)-Avi-tagged | +Inquiry |
ABCE1-204M | Recombinant Mouse ABCE1 Protein, His (Fc)-Avi-tagged | +Inquiry |
ABCE1-11R | Recombinant Rhesus Macaque ABCE1 Protein, His (Fc)-Avi-tagged | +Inquiry |
ABCE1-3481H | Recombinant Human ABCE1 protein, His-tagged | +Inquiry |
◆ Lysates | ||
ABCE1-9145HCL | Recombinant Human ABCE1 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (20)
Ask a questionit is plausible that cellular stress responses, such as nutrient availability, environmental stresses, or cellular growth signals, could impact ABCE1 function and localization
It directly interacts with eukaryotic release factors eRF1 and eRF3, facilitating the dissociation of post-termination ribosomal complexes. These interactions contribute to the overall coordination of translation termination and ribosome recycling processes.
ABCE1 is evolutionarily conserved across different species, indicating its importance in fundamental cellular processes. It is found in a wide range of organisms, including bacteria, archaea, and eukaryotes.
ABCE1 interacts with PINK1, CNOT4 and PELO. What's more,it probably heterodimerizes with RNASEL; this interaction inhibits RNASEL.
It is known to associate with ribosomes and is generally considered to be a cytoplasmic protein
The three-dimensional structure of ABCE1 has been determined using X-ray crystallography and cryo-electron microscopy techniques. It consists of two main domains: the nucleotide-binding domain (NBD) and the C-terminal domain (CTD)
ABCE1 has been implicated in cellular stress responses. It is involved in stress granule formation, which is a cellular response to various stresses, including oxidative stress and heat shock. Stress granules are dynamic cytoplasmic aggregates that sequester untranslated mRNAs and RNA-binding proteins during stress conditions.
Cotranslational quality control factor involved in the No-Go Decay (NGD) pathway
The NBD binds and hydrolyzes ATP, while the CTD contributes to protein-protein interactions involved in ribosome recycling.
Interacts with HIV-1 proteins Vif and Gag
ABCE1 has been implicated in cellular processes, including ribosome biogenesis, RNA degradation, and RNA interference.
The main function of ABCE1 is to participate in translation termination, which is a crucial step in protein synthesis
ABCE1 participates in multiple cellular pathways and processes. Apart from its role in ribosome recycling, it is also involved in mRNA surveillance, RNA quality control, and the assembly of stress granules.
While ABCE1's primary known roles are in ribosome recycling and mRNA surveillance, emerging evidence suggests it may have additional functions and interactions. Some studies have indicated potential involvement in DNA repair processes and modulation of microRNA activity
Post-translational modifications can impact ABCE1 activity or function. For example, phosphorylation has been shown to modulate ABCE1's interaction with other proteins involved in translation termination and ribosome recycling.
Pontocerebellar hypoplasia (PCH), Breast cancer and Viral infections are related to ABCE1's involvement.
It is known that ABCE1 activity can be modulated by various factors, including post-translational modifications and interactions with other proteins.
ABCE1 has been found to interact with several proteins involved in ribosome recycling and RNA metabolism. Some of its known interacting partners include eukaryotic release factors eRF1 and eRF3, as well as other ribosomal proteins.
Belongs to the ABC transporter superfamily. ABCE family.
given its involvement in fundamental cellular processes such as translation termination and ribosome recycling, it is likely to play essential roles in these processes during development and in specific tissues
Customer Reviews (5)
Write a reviewI was provided detailed technical support whenever I needed assistance.
Using the protein product significantly enhanced the expression level of my target protein.
I appreciated that the protein product had no unusual odor or caused any adverse reactions
It offered comparable or even superior features
The ABCE1 has minimal impurities.
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