ABCE1
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Official Full Name
ATP-binding cassette, sub-family E (OABP), member 1
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Overview
ATP binding cassette E1 (ABCE1, also RNase L inhibitor) is an ATPase found in humans involved in viral assembly. It is a member of the ATP-binding cassette (ABC) transporters superfamily and OABP subfamily. ABCE1 inhibits the action of ribonuclease L. Ribonuclease L normally binds to 2-5A (5'-phosphorylated 2',5'-linked oligoadenylates) and inhibits the interferon-regulated 2-5A/RNase L pathway, which is used by viruses. ABCE1 heterodimerize with ribonuclease L and prevents its interaction with 2-5A, antagonizing the anti-viral properties of ribonuclease L, and allow the virus to synthesize viral proteins. It has also been implicated to have an effect in tumor cell proliferation and antiapoptosis. -
Synonyms
RLI; OABP; ABC38; RNS4I; RNASEL1; RNASELI; ATP-binding cassette, sub-family E (OABP), member 1; ABCE1;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Rhesus Macaque
- Zebrafish
- E.coli
- E.Coli or Yeast
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian Cell
- Mammalian cells
- Flag
- GST
- His
- His (Fc)
- Avi
- His|T7
- Myc
- DDK
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- ABCE1 Related Articles
ABCE1 involved in several pathways and played different roles in them. We selected most pathways ABCE1 participated on our site, such as ABC-family proteins mediated transport, Transmembrane transport of small molecules, which may be useful for your reference. Also, other proteins which involved in the same pathway with ABCE1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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ABC-family proteins mediated transport | EIF2S1A;ABCA4A;ABCE1;ABCD3B;EIF2S3;CFTR;APOA1B;ABCC9;ABCA7 |
Transmembrane transport of small molecules | TRPC4A;TRPC4AP;ATP2B3A;SLC4A3;SLC8A2A;SLC39A2;RHCGB;ANO9;SLC6A20A |
ABCE1 has several biochemical functions, for example, ATP binding, ATPase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ABCE1 itself. We selected most functions ABCE1 had, and list some proteins which have the same functions with ABCE1. You can find most of the proteins on our site.
Function | Related Protein |
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ATP binding | CDK11B;CLCN3;TOP2A;NEK2;PMS2;CDC7;PI4K2A;DDX19;GAK |
ATPase activity | ABCD3;KIFC3;HLTF;KIF3CB;DNAH6;PSMC3;ATAD1B;HSPA1B;Abca2 |
protein binding | UBA6;RAB10;CRMP1;PAM16;TTBK2;EIF4EBP2;LMNA;SIN3B;ASF1B |
ribonuclease inhibitor activity | RNH1;ABCE1 |
ABCE1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ABCE1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ABCE1.
gag; M; EIF3H; USP50; Kif13b; Cdc6; XRCC5; VCAM1; Brca1; ILK; LRRK2; Sidt2
- Q&As
- Reviews
Q&As (20)
Ask a questionit is plausible that cellular stress responses, such as nutrient availability, environmental stresses, or cellular growth signals, could impact ABCE1 function and localization
It directly interacts with eukaryotic release factors eRF1 and eRF3, facilitating the dissociation of post-termination ribosomal complexes. These interactions contribute to the overall coordination of translation termination and ribosome recycling processes.
ABCE1 is evolutionarily conserved across different species, indicating its importance in fundamental cellular processes. It is found in a wide range of organisms, including bacteria, archaea, and eukaryotes.
ABCE1 interacts with PINK1, CNOT4 and PELO. What's more,it probably heterodimerizes with RNASEL; this interaction inhibits RNASEL.
It is known to associate with ribosomes and is generally considered to be a cytoplasmic protein
The three-dimensional structure of ABCE1 has been determined using X-ray crystallography and cryo-electron microscopy techniques. It consists of two main domains: the nucleotide-binding domain (NBD) and the C-terminal domain (CTD)
ABCE1 has been implicated in cellular stress responses. It is involved in stress granule formation, which is a cellular response to various stresses, including oxidative stress and heat shock. Stress granules are dynamic cytoplasmic aggregates that sequester untranslated mRNAs and RNA-binding proteins during stress conditions.
Cotranslational quality control factor involved in the No-Go Decay (NGD) pathway
The NBD binds and hydrolyzes ATP, while the CTD contributes to protein-protein interactions involved in ribosome recycling.
Interacts with HIV-1 proteins Vif and Gag
ABCE1 has been implicated in cellular processes, including ribosome biogenesis, RNA degradation, and RNA interference.
The main function of ABCE1 is to participate in translation termination, which is a crucial step in protein synthesis
ABCE1 participates in multiple cellular pathways and processes. Apart from its role in ribosome recycling, it is also involved in mRNA surveillance, RNA quality control, and the assembly of stress granules.
While ABCE1's primary known roles are in ribosome recycling and mRNA surveillance, emerging evidence suggests it may have additional functions and interactions. Some studies have indicated potential involvement in DNA repair processes and modulation of microRNA activity
Post-translational modifications can impact ABCE1 activity or function. For example, phosphorylation has been shown to modulate ABCE1's interaction with other proteins involved in translation termination and ribosome recycling.
Pontocerebellar hypoplasia (PCH), Breast cancer and Viral infections are related to ABCE1's involvement.
It is known that ABCE1 activity can be modulated by various factors, including post-translational modifications and interactions with other proteins.
ABCE1 has been found to interact with several proteins involved in ribosome recycling and RNA metabolism. Some of its known interacting partners include eukaryotic release factors eRF1 and eRF3, as well as other ribosomal proteins.
Belongs to the ABC transporter superfamily. ABCE family.
given its involvement in fundamental cellular processes such as translation termination and ribosome recycling, it is likely to play essential roles in these processes during development and in specific tissues
Customer Reviews (5)
Write a reviewI was provided detailed technical support whenever I needed assistance.
Using the protein product significantly enhanced the expression level of my target protein.
I appreciated that the protein product had no unusual odor or caused any adverse reactions
It offered comparable or even superior features
The ABCE1 has minimal impurities.
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