Recombinant Mouse ANO10 Protein, His (Fc)-Avi-tagged

• Cat.No.: ANO10-567M
• Product Overview: Recombinant Mouse ANO10 with His (Fc)-Avi tag was expressed and purified

Specification

• Source: HEK293
• Species: Mouse
• Tag: His (Fc)-Avi
• Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method
• Purity: ≥85% by SDS-PAGE
• Stability: Stable for at least 6 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: For long term storage, aliquot and store at -20 to -80 centigrade. Avoid repeated freezing and thawing cycles.
• Storage Buffer: PBS buffer

Gene Information

• Gene Name: Ano10 anoctamin 10 [ Mus musculus ]
• Official Symbol: ANO10
• Gene ID: 102566
• mRNA Refseq: NM_133979.2
• Protein Refseq: NP_598740.1
• UniProt ID: Q8BH79

Reviews

09/03/2021

The manufacturer can provide researchers with high-quality ANO10 protein, ensuring it is properly purified, characterized, and quality-controlled.

03/16/2021

This may include options like different formulations, protein modifications, or tagging techniques. Customization can enhance the versatility of the protein and optimize its utility in the intended research.

08/01/2020

They can also address any questions or concerns regarding the ANO10 protein, thereby facilitating smooth and efficient research execution.

01/23/2019

manufacturers may offer customization options, allowing researchers to tailor the ANO10 protein to their specific needs.

03/05/2017

This collaboration may extend beyond the purchase of the ANO10 protein, potentially leading to additional support, joint research projects, or access to expertise in the field.

Q&As

Is ANO10 involved in any physiological processes?

ANO10 may play a role in various physiological processes. For example, it has been suggested to be involved in neurotransmitter release, skeletal muscle function, and regulation of lipid metabolism. However, more research is needed to fully understand its physiological functions.

Are there any animal models for studying ANO10 dysfunction?

Animal models are valuable tools for studying the function and dysfunction of genes, including ANO10. Currently, there are no specific animal models for ANO10-related disorders. However, researchers have used other animal models, such as mice and zebrafish, to study the broader functions of ANO10 or related genes. These models provide insights into the physiological roles and potential therapeutic strategies related to ANO10.

What are the current treatment options for ANO10-related disorders?

Currently, there are no specific treatments available to cure or halt the progression of ANO10-related disorders. Instead, treatment focuses on managing the symptoms and improving the quality of life for affected individuals. This may involve physical therapy, occupational therapy, speech therapy, and assistive devices to cope with motor impairments and maintain independence. Additional symptom-specific medications may be prescribed to address specific symptoms such as muscle stiffness or tremors. Research is ongoing to develop targeted therapies that can address the underlying molecular mechanisms of ANO10-related disorders.

Where is ANO10 expressed in the body?

ANO10 is expressed in various tissues throughout the body, including the brain, skeletal muscles, heart, liver, and kidneys.

Can ANO10 mutations be inherited?

Yes, ANO10 mutations can be inherited in different patterns depending on the specific disorder. Spinocerebellar ataxia type 10 (SCA10) is primarily inherited in an autosomal dominant manner, meaning a person only needs to inherit one copy of the mutated ANO10 gene from one parent to develop the disorder. However, there are also reports of recessive inheritance patterns and de novo mutations in ANO10-related disorders. Genetic counseling and testing are essential for affected individuals and their families to determine the mode of inheritance and assess the risk of passing on the mutations to future generations.

Are there any genetic disorders associated with ANO10 mutations?

Yes, mutations in the ANO10 gene have been linked to several genetic disorders. For example, mutations in ANO10 have been identified in patients with autosomal recessive spinocerebellar ataxia type 10 (SCAR10), a neurodegenerative disorder characterized by progressive cerebellar ataxia.

Can genetic testing be done to diagnose ANO10-related disorders?

Yes, genetic testing can be performed to diagnose ANO10-related disorders, such as spinocerebellar ataxia type 10. Analysis of the ANO10 gene can identify pathogenic mutations that are associated with these disorders. Genetic testing is typically done through a blood or saliva sample, and it may be recommended for individuals with symptoms suggestive of ANO10-related conditions or in families with a history of these disorders.

Are there any other diseases or conditions associated with ANO10?

In addition to spinocerebellar ataxia type 10, ANO10 mutations have also been reported in individuals with parkinsonism, dystonia, and craniocervical dystonia. Further research is needed to fully understand the role of ANO10 in these conditions.

Are there any potential therapeutic targets related to ANO10?

Due to the limited knowledge about ANO10's exact function, potential therapeutic targets related to ANO10 are yet to be defined. However, further research into ANO10's role in cellular processes and associated diseases may provide insights for future therapeutic strategies.

Is there any ongoing research on ANO10?

Yes, there is ongoing research on ANO10. Scientists are working to uncover the exact function and regulation of ANO10, as well as its roles in various diseases. This includes studying its involvement in cancer progression, exploring its potential as a therapeutic target, and investigating its role in other neurological disorders.

Can mutations in ANO10 lead to other neurological disorders?

While ANO10 mutations have been primarily associated with spinocerebellar ataxia type 10, there is growing evidence linking ANO10 mutations to other neurological disorders. These include parkinsonism, dystonia, hereditary spastic paraplegia, and autosomal recessive cerebellar ataxia. Further research is necessary to fully understand the extent of ANO10's involvement in these disorders.

What are the physiological functions of ANO10?

The exact physiological functions of ANO10 are not fully understood. However, studies suggest that ANO10 may play a role in a variety of cellular processes, including calcium signaling, membrane trafficking, and lipid metabolism. ANO10 has been implicated in processes such as ciliary function, autophagy, and phagocytosis. Further research is needed to fully elucidate the specific functions of ANO10 in different cell types and tissues.

Are there any other genetic disorders associated with ANO10 mutations?

Yes, besides spinocerebellar ataxia type 10 (SCA10), mutations in the ANO10 gene have been associated with other disorders. For example, ANO10 mutations have been identified in individuals with autosomal recessive cerebellar ataxia and parkinsonism.

Is ANO10 associated with any cancer types?

ANO10 has been implicated in the development and progression of certain cancer types. It has been found to be overexpressed in colorectal cancer, gastric cancer, and pancreatic cancer, and its upregulation is linked to poor patient prognosis. However, the exact mechanisms through which ANO10 contributes to cancer progression are still being investigated.