Recombinant Mouse ANO5 Protein

• Cat.No.: ANO5-1701M
• Product Overview: Recombinant Mouse ANO5 full length or partial length protein was expressed.

Specification

• Source: Mammalian Cells
• Species: Mouse
• Tag: His
• Form: Liquid or lyophilized powder
• Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method.
• Purity: >80%
• Notes: This item requires custom production and lead time is between 5-9 weeks. We can custom produce according to your specifications.
• Storage: Store it at +4 ºC for short term. For long term storage, store it at -20 ºC～-80 ºC.
• Storage Buffer: PBS buffer

Gene Information

• Gene Name: Ano5 anoctamin 5 [ Mus musculus ]
• Official Symbol: ANO5
• Gene ID: 233246
• mRNA Refseq: NM_177694.5
• Protein Refseq: NP_808362.2
• UniProt ID: Q75UR0

Reviews

11/28/2021

the high-quality ANO5 protein is available in various forms, including recombinant proteins and purified samples, enabling researchers to select the most suitable format for their specific experimental setup.

04/12/2020

The knowledgeable and responsive support team is dedicated to resolving issues and providing solutions that are tailored to specific experimental requirements.

12/04/2018

This enables researchers to confidently incorporate ANO5 into their studies, knowing that they have access to a reliable and well-characterized protein that will contribute to robust and accurate results.

03/22/2018

the ANO5 protein is carefully characterized, and its functional properties are well-documented.

Q&As

Does ANO5 protein have any role in cancer?

Currently, there is limited information on the involvement of ANO5 protein in cancer. Some studies have suggested a potential association between ANO5 expression and certain cancer types. However, more research is needed to determine the exact role, if any, of ANO5 in cancer development or progression.

Can ANO5 mutations cause bone abnormalities?

Yes, ANO5 mutations have been associated with gnathodiaphyseal dysplasia, a rare bone disorder characterized by increased bone density, tooth abnormalities, and fractures. The exact mechanisms by which ANO5 mutations lead to bone abnormalities are not fully understood.

Is ANO5 protein implicated in other types of muscular dystrophies?

While ANO5 mutations are primarily associated with Miyoshi muscular dystrophy type 3, they have also been identified in some cases of limb-girdle muscular dystrophy and distal myopathy. These findings suggest a broader role for ANO5 in muscle-related conditions.

Is ANO5 protein involved in membrane trafficking?

Yes, ANO5 protein has been suggested to be involved in membrane trafficking processes. It interacts with proteins involved in vesicle fusion and intracellular transport, indicating its potential role in regulating membrane dynamics.

What are the different types of ANO5-related muscle disorders?

ANO5-related muscle disorders include Miyoshi muscular dystrophy type 3 (MMD3), limb-girdle muscular dystrophy type 2L (LGMD2L), and distal myopathy (DM). These disorders are characterized by progressive muscle weakness and atrophy, typically affecting the lower limbs first.

Are there any potential therapeutic targets for ANO5-related disorders?

The understanding of ANO5-related disorders is still evolving, and the identification of specific therapeutic targets is an ongoing area of research. However, strategies such as gene therapy, muscle-specific gene delivery, and modulation of calcium-activated chloride channels hold promise as potential therapeutic avenues.

How do ANO5 mutations contribute to the development of muscular dystrophies?

Mutations in the ANO5 gene can lead to abnormal protein function or reduced protein levels, which disrupts normal muscle membrane repair mechanisms. This disruption compromises muscle health and can contribute to the development of muscular dystrophies.

How is ANO5 protein involved in membrane repair?

ANO5 protein has been implicated in the repair of damaged muscle cell membranes. It is thought to participate in the resealing of membrane disruptions by facilitating the fusion of intracellular vesicles with the damaged membrane, thus preventing the loss of cellular contents and maintaining membrane integrity.

Can ANO5 mutations lead to muscle inflammation?

Yes, ANO5 mutations have been associated with muscle inflammation. In some cases, individuals with ANO5-related muscle disorders may experience ongoing muscle inflammation, which can contribute to muscle weakness and damage.

Can ANO5 mutations lead to cardiomyopathy?

Yes, ANO5 mutations have been associated with cardiomyopathy, particularly dilated cardiomyopathy, which is a condition characterized by the enlargement of the heart chambers and reduced cardiac function.

Does ANO5 protein have any structural similarities with other proteins?

ANO5 protein shares structural similarities with other members of the Anoctamin family, including conserved transmembrane domains and intracellular loops. These proteins have similar overall architectures.

Are there any known functions of ANO5 protein in non-muscle tissues?

While ANO5's functions in non-muscle tissues are not fully understood, studies have suggested its involvement in processes such as cell migration, calcium signaling, and lipid metabolism. However, further research is needed to elucidate its specific roles in these contexts.

Are there any therapies or treatments targeting ANO5-related disorders?

Currently, there are no specific therapies or treatments available for ANO5-related disorders. Management of these conditions typically involves symptomatic and supportive care, such as physical therapy and orthopedic interventions, to address muscle weakness and associated complications.

Is ANO5 protein involved in calcium signaling?

ANO5 protein has been implicated in calcium-dependent signaling, although the exact mechanisms are not fully understood. It may participate in calcium homeostasis and intracellular calcium signaling pathways.

Is ANO5 protein involved in calcium-activated chloride currents?

ANO5 protein is known to function as a calcium-activated chloride channel. It can mediate calcium-dependent chloride currents, which are involved in various physiological processes, including cell volume regulation and secretion.

Can ANO5 protein regulate ion channels?

Yes, ANO5 protein has been shown to interact with and regulate certain ion channels, such as the calcium-activated chloride channels (CaCCs). It can modulate their activity and calcium-dependent signaling pathways.

How is ANO5 protein involved in muscle regeneration?

ANO5 protein plays a role in muscle regeneration by participating in the repair process of injured muscle fibers. It aids in the incorporation of new membrane material to the damaged areas, facilitating the restoration of functional muscles.

Are there any animal models available for studying ANO5-related diseases?

Yes, various animal models, including mouse and zebrafish models, have been generated to study ANO5-related diseases. These models help researchers understand the molecular mechanisms underlying these disorders and explore potential therapeutic approaches.

Are there any known inhibitors or activators of ANO5 protein?

Currently, there are no specific inhibitors or activators of ANO5 protein that have been widely characterized. Further research is needed to identify such molecules.

Are there any genetic disorders associated with ANO5 protein?

Yes, mutations in the ANO5 gene have been linked to several genetic disorders, including Miyoshi muscular dystrophy 3 (MMD3) and gnathodiaphyseal dysplasia. These disorders affect muscle and bone development.

Can ANO5 protein interact with other proteins?

Yes, ANO5 protein has been shown to interact with several other proteins. For example, it interacts with dysferlin, a protein involved in muscular dystrophy, and myomatrin, another member of the Anoctamin family. These interactions may be important for ANO5's normal function and regulation.

Can ANO5 protein be used as a biomarker for any diseases?

The potential use of ANO5 protein as a biomarker for specific diseases is still being investigated. However, some studies have suggested its potential as a biomarker for certain types of muscular dystrophies. Further research is needed in this area.