Recombinant Mouse ARPC1A Protein, His (Fc)-Avi-tagged
Cat.No. : | ARPC1A-747M |
Product Overview : | Recombinant Mouse ARPC1A with His (Fc)-Avi tag was expressed and purified |
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Source : | HEK293 |
Species : | Mouse |
Tag : | His (Fc)-Avi |
Endotoxin : | < 1.0 EU per μg of the protein as determined by the LAL method |
Purity : | ≥85% by SDS-PAGE |
Stability : | Stable for at least 6 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
Storage : | For long term storage, aliquot and store at -20 to -80 centigrade. Avoid repeated freezing and thawing cycles. |
Storage Buffer : | PBS buffer |
Gene Name : | Arpc1a actin related protein 2/3 complex, subunit 1A [ Mus musculus ] |
Official Symbol : | ARPC1A |
Gene ID : | 56443 |
mRNA Refseq : | NM_019767.2 |
Protein Refseq : | NP_062741.1 |
UniProt ID : | Q9R0Q6 |
Products Types
◆ Recombinant Protein | ||
ARPC1A-453R | Recombinant Rat ARPC1A Protein, His (Fc)-Avi-tagged | +Inquiry |
Arpc1a-1724M | Recombinant Mouse Arpc1a Protein, Myc/DDK-tagged | +Inquiry |
ARPC1A-151H | Recombinant Human ARPC1A Protein, His-tagged | +Inquiry |
ARPC1A-844H | Recombinant Human ARPC1A protein, GST-tagged | +Inquiry |
ARPC1A-9881H | Recombinant Human ARPC1A, GST-tagged | +Inquiry |
◆ Lysates | ||
ARPC1A-8687HCL | Recombinant Human ARPC1A 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (7)
Ask a questionYes, the ARPC1A protein can undergo post-translational modifications, including phosphorylation and acetylation, which may regulate its activity and interactions with other proteins. The specific effects and functional significance of these modifications are still being studied.
Yes, in addition to its association with the other subunits of the Arp2/3 complex, the ARPC1A protein can interact with various actin-binding proteins and regulatory factors. For example, it can associate with WASP (Wiskott-Aldrich syndrome protein) family members, which play a crucial role in actin cytoskeleton regulation.
The ARPC1A protein consists of multiple domains that are involved in protein-protein interactions. It has a predicted alpha-helical coiled-coil domain near the N-terminus, which mediates interactions with other subunits of the Arp2/3 complex. The C-terminus of ARPC1A contains an actin-binding-like domain (ABD) that helps anchor the complex to newly polymerized actin filaments.
The ARPC1A protein interacts with other subunits of the Arp2/3 complex, such as ARPC1B, ARPC2, and ARPC5, to form the functional complex. It also interacts with various actin-binding proteins, regulatory proteins, and signaling molecules that help regulate actin polymerization and participate in specific cellular processes.
Yes, the ARPC1A protein is expressed in most, if not all, cell types. Actin filament nucleation and branching are essential processes for various cellular functions, so the ARPC1A protein is required in a wide range of cell types and tissues.
Yes, mutations in the ARPC1A gene have been linked to a rare genetic disorder called ARPC1A-related intellectual disability, which is characterized by developmental delay, intellectual disability, and distinctive facial features. These mutations can disrupt the normal function of the ARPC1A protein, impairing actin filament nucleation and branching processes.
The activity and expression of the ARPC1A protein can be regulated in multiple ways. It can be regulated at the transcriptional level through various transcription factors and signaling pathways. Post-translational modifications, such as phosphorylation and acetylation, can also regulate its activity. Additionally, the availability of other subunits of the Arp2/3 complex can influence the assembly and stability of the complex, thereby affecting ARPC1A function.
Customer Reviews (3)
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Used in protein electron microscopy structure analysis.Great.
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