Recombinant Mouse Elac1 Protein, MYC/DDK-tagged

• Cat.No.: Elac1-520M
• Product Overview: Purified recombinant protein of full-length mouse elaC ribonuclease Z 1 (Elac1), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Description: Ubiquitous expression in cerebellum adult (RPKM 4.6), frontal lobe adult (RPKM 3.9) and 28 other tissues.
• Source: HEK293T
• Species: Mouse
• Tag: MYC/DDK
• Molecular Mass: 39.7 kDa
• Purity: >80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Elac1 elaC ribonuclease Z 1 [ Mus musculus (house mouse) ]
• Official Symbol: Elac1
• Synonyms: Elac1; elaC ribonuclease Z 1; 2610018O07Rik; 8430417G19Rik; zinc phosphodiesterase ELAC protein 1; RNase Z 1; elaC homolog 1; elaC homolog protein 1; ribonuclease Z 1; tRNA 3 endonuclease 1; tRNase Z 1; EC 3.1.26.11
• Gene ID: 114615
• mRNA Refseq: NM_053255
• Protein Refseq: NP_444485
• UniProt ID: Q8VEB6

Reviews

03/07/2018

The ELAC1 Protein exhibits remarkable stability and functionality, making it an optimal choice for a wide range of applications in various fields.

10/31/2017

Its exceptional purity and consistency have consistently yielded reliable and reproducible results, ensuring the accuracy and reliability of my research outcomes.

07/10/2016

Their prompt and knowledgeable assistance has been instrumental in overcoming hurdles and has significantly contributed to the success of my research.

Q&As

How is ELAC1 protein relevant to mitochondrial disorders?

ELAC1 protein is involved in maintaining mitochondrial function, and mutations in the ELAC1 gene can contribute to mitochondrial disorders.

Are there any clinical trials focusing on ELAC1 protein for mitochondrial disorders?

Clinical trials investigating the role of ELAC1 protein in mitochondrial disorders are currently underway, aiming to develop targeted therapies.

Are there any specific treatments targeting ELAC1 protein for mitochondrial disorders?

As of now, there are no specific treatments targeting ELAC1 protein for mitochondrial disorders, but ongoing research may lead to future therapeutic approaches.

What other diseases are associated with mutations in ELAC1 gene?

In addition to pontocerebellar hypoplasia and mitochondrial disorders, mutations in ELAC1 gene have been linked to infantile hypertrophic cardiomyopathy.

How does ELAC1 protein affect cardiac function?

ELAC1 protein plays a role in mitochondrial RNA processing, which is essential for proper cardiac function. Mutations in ELAC1 gene can lead to cardiomyopathy.