Recombinant Rat Arsb, His-tagged

• Cat.No.: Arsb-3659R
• Product Overview: Arylsulfatase B (Arsb)

Specification

• Source: E. Coli or Yeast
• Species: Rat
• Tag: His
• Form: This item requires custom production and lead time is between 5-9 weeks. We can custom produce according to your specifications.
• Protein length: 528
• Purity: >90%
• Notes: Small volumes of Arsb recombinant protein may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice.
• Storage: Store at -20 degree C. For extended storage, store at -20 or -80 degree C.
• Storage Buffer: PBS pH 7.4, 50% glycerol
• Warning: This product is for research use only. Not for use in diagnostic or therapeutic procedures.

Gene Information

• Gene Name: Arsb
• Official Symbol: Arsb
• Synonyms: Arsb ; Arsb; Arsb; ASB; G4S
• Gene ID: 25227
• mRNA Refseq: NM_033443.1
• Protein Refseq: NP_254278.1
• UniProt ID: P50430
• Chromosome Location: Chromosome: 2; NC_005101.3 (42559854..42717753). Location: 2q12

Reviews

01/25/2023

the ARSB protein has proven to be a valuable asset in protein electron microscopy structure analysis.

09/09/2019

By utilizing the ARSB protein, researchers can unravel the intricate three-dimensional architecture of proteins, furthering our understanding of their function and facilitating the development of novel therapeutic interventions.

08/03/2019

The ARSB protein's superior performance in ELISA paves the way for robust and precise data analysis, providing invaluable insights into various biological processes.

Q&As

Is the ARSB protein involved in any other biological processes or diseases?

Although the primary function of the ARSB protein is related to the breakdown of GAGs, recent studies have suggested its involvement in other biological processes. It has been implicated in cellular signaling, inflammatory responses, and tissue remodeling. Additionally, ARSB mutations or dysregulation have been associated with certain cancers, neurodegenerative disorders, and metabolic disorders.

Are there any known mutations or variations in the ARSB gene?

Yes, mutations in the ARSB gene can cause mucopolysaccharidosis type VI (MPS VI). Over 170 different mutations have been identified, including insertions, deletions, and point mutations, each leading to a deficiency in ARSB enzyme activity.

What are the consequences of ARSB protein deficiency?

A deficiency in the ARSB protein leads to a rare inherited disorder called mucopolysaccharidosis type VI (MPS VI). This condition results in the accumulation of GAGs in various tissues and organs, causing various symptoms including skeletal abnormalities, cardiovascular issues, respiratory problems, and impaired vision and hearing.

How is the ARSB protein regulated in the body?

The expression of the ARSB protein is regulated by various factors, including transcription factors and signaling pathways that control gene expression. Additionally, post-translational modifications such as phosphorylation or glycosylation can affect its activity and localization within the cell.

Are there any treatments available for mucopolysaccharidosis type VI?

Yes, there are treatments available for mucopolysaccharidosis type VI. Enzyme replacement therapy (ERT) involves regular infusion of a man-made version of the ARSB enzyme to help break down the accumulated GAGs. Additionally, supportive therapies such as physical therapy, surgery, and medications are utilized to manage symptoms and complications. Gene therapy approaches are also being explored.

How is the ARSB protein related to lysosomal storage disorders?

Mutations in the ARSB gene lead to a deficiency in the ARSB enzyme, resulting in the accumulation of GAGs within lysosomes. This accumulation is characteristic of lysosomal storage disorders, including mucopolysaccharidosis type VI. These disorders occur due to impaired lysosomal function, which leads to the build-up of undigested substances and subsequent cellular dysfunction.