ARSB
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Official Full Name
arylsulfatase B
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Overview
Arylsulfatase B encoded by this gene belongs to the sulfatase family. The arylsulfatase B homodimer hydrolyzes sulfate groups of N-Acetyl-D-galactosamine, chondriotin sulfate, and dermatan sulfate. The protein is targetted to the lysozyme. Mucopolysaccharidosis type VI is an autosomal recessive lysosomal storage disorder resulting from a deficiency of arylsulfatase B. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. -
Synonyms
ARSB; arylsulfatase B; ARSB_HUMAN; ArylsulfataseB; ASB; G4S; MPS6; N acetylgalactosamine 4 sulfatase; N-acetylgalactosamine-4-sulfatase; OTTHUMP00000135268; OTTHUMP00000222674;
- Recombinant Proteins
- Cell & Tissue Lysates
- Therapeutic Proteins
- Protein Pre-coupled Magnetic Beads
- Bacillus subtilis
- Human
- Mouse
- Rat
- Staphylococcus
- CHO
- E. coli or Yeast
- E.coli
- E.Coli or Yeast
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian Cell
- Mammalian cells
- Wheat Germ
- Yeast
- Flag
- GST
- His
- His (Fc)
- Avi
- SUMO
- Myc
- DDK
- MYC
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
- ARSB Related Articles
- ARSB Related Research Area
ARSB involved in several pathways and played different roles in them. We selected most pathways ARSB participated on our site, such as Glycosaminoglycan degradation, Metabolic pathways, Lysosome, which may be useful for your reference. Also, other proteins which involved in the same pathway with ARSB were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Glycosaminoglycan degradation | GALNS;NAGLU;HPSE2;SPAM1;HYAL6;HYAL2;GNSA;HYAL1;GNSB |
Metabolic pathways | PDHX;SPTLC2;NDUFV1;MOGS;OXSR1;XYLB;GMPPB;RGN;AGPAT4 |
Lysosome | IDUA;CTSE;HEXA;LAPTM4B;ATP6AP1;GUSB;TCIRG1;ACP5B;GALC |
ARSB has several biochemical functions, for example, N-acetylgalactosamine-4-sulfatase activity, arylsulfatase activity, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ARSB itself. We selected most functions ARSB had, and list some proteins which have the same functions with ARSB. You can find most of the proteins on our site.
Function | Related Protein |
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N-acetylgalactosamine-4-sulfatase activity | GALNS;ARSB |
arylsulfatase activity | ARSE;SULF2;ARSA;ARSG;ARSJ;ARSB;ARSI;ARSD;ARSF |
metal ion binding | PRKCBB;GNA11;ZFP770;LPO;CIZ1B;ZBBX;UNC13C;ADARB2;TCN2 |
ARSB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ARSB here. Most of them are supplied by our site. Hope this information will be useful for your research of ARSB.
MYC; ESR1
- Q&As
- Reviews
Q&As (6)
Ask a questionAlthough the primary function of the ARSB protein is related to the breakdown of GAGs, recent studies have suggested its involvement in other biological processes. It has been implicated in cellular signaling, inflammatory responses, and tissue remodeling. Additionally, ARSB mutations or dysregulation have been associated with certain cancers, neurodegenerative disorders, and metabolic disorders.
Yes, mutations in the ARSB gene can cause mucopolysaccharidosis type VI (MPS VI). Over 170 different mutations have been identified, including insertions, deletions, and point mutations, each leading to a deficiency in ARSB enzyme activity.
A deficiency in the ARSB protein leads to a rare inherited disorder called mucopolysaccharidosis type VI (MPS VI). This condition results in the accumulation of GAGs in various tissues and organs, causing various symptoms including skeletal abnormalities, cardiovascular issues, respiratory problems, and impaired vision and hearing.
The expression of the ARSB protein is regulated by various factors, including transcription factors and signaling pathways that control gene expression. Additionally, post-translational modifications such as phosphorylation or glycosylation can affect its activity and localization within the cell.
Yes, there are treatments available for mucopolysaccharidosis type VI. Enzyme replacement therapy (ERT) involves regular infusion of a man-made version of the ARSB enzyme to help break down the accumulated GAGs. Additionally, supportive therapies such as physical therapy, surgery, and medications are utilized to manage symptoms and complications. Gene therapy approaches are also being explored.
Mutations in the ARSB gene lead to a deficiency in the ARSB enzyme, resulting in the accumulation of GAGs within lysosomes. This accumulation is characteristic of lysosomal storage disorders, including mucopolysaccharidosis type VI. These disorders occur due to impaired lysosomal function, which leads to the build-up of undigested substances and subsequent cellular dysfunction.
Customer Reviews (3)
Write a reviewthe ARSB protein has proven to be a valuable asset in protein electron microscopy structure analysis.
By utilizing the ARSB protein, researchers can unravel the intricate three-dimensional architecture of proteins, furthering our understanding of their function and facilitating the development of novel therapeutic interventions.
The ARSB protein's superior performance in ELISA paves the way for robust and precise data analysis, providing invaluable insights into various biological processes.
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