Recombinant Rat Atxn1 Protein (Thr543-Ile781), N-His tagged

• Cat.No.: Atxn1-6853R
• Product Overview: Recombinant Rattus norvegicusATX1 (Thr543-Ile781) fused with the N-His tag was expressed in E. coli.

Specification

• Description: Predicted to enable several functions, including identical protein binding activity; protein C-terminus binding activity; and single-stranded RNA binding activity. Predicted to be involved in several processes, including learning or memory; negative regulation of transcription by RNA polymerase II; and social behavior. Predicted to act upstream of or within several processes, including negative regulation of insulin-like growth factor receptor signaling pathway; positive regulation of glial cell proliferation; and visual learning. Predicted to be located in cytosol; nuclear inclusion body; and nuclear lumen. Predicted to be part of protein-containing complex. Predicted to be active in nucleus. Human ortholog (s) of this gene implicated in spinocerebellar ataxia type 1. Orthologous to human ATXN1 (ataxin 1).
• Source: E. coli
• Species: Rat
• Tag: N-His
• Form: Lyophilized powder/frozen liquid
• Molecular Mass: 28.55 kDa
• Protein Length: Thr543-Ile781
• Purity: > 90 % as determined by SDS-PAGE
• Notes: For research use only.
• Storage: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8 centigrade for one week. Store at -20 to -80 centigrade for twelve months from the date of receipt.
• Storage Buffer: Supplied as solution form in PBS, pH 7.5 or lyophilized from PBS, pH 7.5.
• Reconstitution: Reconstitute in sterile water for a stock solution.
• Shipping: They are shipped out with dry ice/blue ice unless customers require otherwise.

Gene Information

• Gene Name: Atxn1 ataxin 1 [ Rattus norvegicus (Norway rat) ]
• Official Symbol: Atxn1
• Synonyms: Atxn1; ataxin 1; Sca1; ataxin-1; spinocerebellar ataxia 1; spinocerebellar ataxia type 1 protein homolog
• Gene ID: 25049
• mRNA Refseq: NM_012726
• Protein Refseq: NP_036858
• UniProt ID: Q63540

Reviews

12/10/2020

Using Atxn1 as a catalyst, the rate and yield of chemical reactions can be significantly increased, and the catalytic efficiency is very high.

10/22/2019

The stability of Atxn1 is very good, and its structure and function remain stable even after several freeze-thaw cycles, which shows its excellent quality control and production process.

06/18/2019

Atxn1 are so simple to prepare that we can easily prepare them ourselves.

Q&As

How do mutations in ATXNprotein cause SCA1?

SCA1 is caused by mutations in the ATXN1 gene. The mutation resulted in the expansion of glutamine repeats in ATXN1 protein, resulting in the formation of abnormal polyglutamic acid protein. This protein abnormality can lead to abnormal neuronal function and degenerative changes, leading to the occurrence of SCA1.

Does ATXNprotein interact with other proteins?

Yes, the ATXN1 protein interacts with multiple proteins to form complexes involved in the regulation of a variety of cellular functions. For example, ATXN1 interacts with the Capicua (CIC) protein and is involved in transcriptional regulation.

Which diseases are associated with ATXNprotein?

The protein is associated with spinocerebellar ataxia type 1 (SCA1). SCA1 is an inherited neurodegenerative disease characterized by dysfunction of the cerebellum and spinal cord, leading to ataxia and other neurological symptoms.

In which tissues is ATXNprotein expressed?

ATXN1 protein is expressed in several tissues, but its expression is higher in the central nervous system, especially in the cerebellum and spinal cord.

What is the regulatory mechanism of ATXNprotein function?

The function of ATXN1 protein is regulated by a variety of regulatory mechanisms, including post-translational modification, assembly of protein complexes, and transcriptional regulation. These regulatory mechanisms ensure the adaptability and stability of ATXN1 protein.

What is the role of ATXNprotein in humans?

ATXN1 protein is involved in the regulation of a variety of neural cell functions, including cell cycle regulation, DNA repair, transcription regulation, etc. It plays an important role in the development and functional maintenance of the nervous system.