Recombinant Rhesus Macaque ARRDC3 Protein Pre-coupled Magnetic Beads

• Cat.No.: ARRDC3-248R-B
• Product Overview: The Recombnant protein was conjugated to magnetic beads. This ready-to-use, pre-coupled magnetic beads are in uniform particle size and narrow size distribution with large surface area, which is conducive to convenient and fast capture target molecules with high specificity and achieve magnetic separation. This product can be equipped with automation equipment for high-throughput operations.

Specification

• Source: HEK293
• Species: Rhesus Macaque
• Form: Solution
• Particle size: ~2 μm
• Beads Surface: Hydrophilic
• Capacity: > 200 pmol rabbit IgG/ mg beads
• Applications: Immunoassay, In vitro diagnostics, cell sorting, Immunoprecipitation/Co-precipitation, Protein/antibody separation and purification.
• Stability: Stable for at least 6 months from the date of receipt of the product under proper storage and handling conditions.
• Storage: 2-8℃. Do not to freeze thaw the Beads
• Concentration: 10mg beads/mL
• Storage Buffer: PBS buffer

Gene Information

• Gene Name: ARRDC3 arrestin domain containing 3 [ Macaca mulatta (Rhesus monkey) ]
• Official Symbol: ARRDC3
• Synonyms: ARRDC3; arrestin domain-containing protein 3; TBP-2-like inducible membrane protein
• Gene ID: 695903
• mRNA Refseq: NM_001260940
• Protein Refseq: NP_001247869
• UniProt ID: F7ETB7

Reviews

09/06/2021

Their unwavering commitment to customer satisfaction assures me that any challenges or queries I may encounter will be expertly resolved.

01/03/2020

I am confident that the ARRDC3 protein will unlock vital insights into cellular processes, propelling my scientific investigations to new heights.

01/27/2017

An additional advantage of selecting the ARRDC3 protein is the outstanding technical support offered by its manufacturer.

Q&As

Does ARRDC3 undergo post-translational modifications?

Yes, ARRDC3 can be subjected to post-translational modifications, although the specific modifications are not well-documented. Phosphorylation has been reported to regulate its cellular localization and function in certain contexts.

Are there any known interacting partners of ARRDC3?

Yes, ARRDC3 has been found to interact with proteins such as beta-arrestins, clathrin, and several G protein-coupled receptors (GPCRs). These interactions suggest its involvement in GPCR signaling and endocytic processes.

Does ARRDC3 have any role in cancer?

There is emerging evidence suggesting a potential role for ARRDC3 in cancer, particularly hepatocellular carcinoma (HCC). It has been found to be downregulated in HCC, and its overexpression can inhibit HCC cell proliferation and invasion.

Is there any evidence of ARRDC3 involvement in cardiac diseases?

Yes, several studies have implicated ARRDC3 in cardiac diseases, such as heart failure and arrhythmias. Its expression has been found to be altered in diseased hearts, and its overexpression has been associated with cardiac dysfunction in mouse models.

Are there any known genetic variants or mutations in the ARRDC3 gene?

Genetic variants or mutations in the ARRDC3 gene have been reported in some studies. These variations may be associated with certain diseases or phenotypic traits, but further research is required to determine their functional significance.

Is ARRDC3 conserved across different species?

ARRDC3 is evolutionarily conserved, meaning it is found in different species, including mammals, birds, and fish. The level of sequence conservation varies, with certain regions being more conserved than others.

How is ARRDC3 associated with lipid metabolism and adipogenesis?

Studies have shown that ARRDC3 can modulate the expression of genes involved in lipid metabolism and adipogenesis. It affects the differentiation of pre-adipocytes into mature adipocytes and can regulate the activity of key transcription factors involved in adipogenesis.

Is there any known association between ARRDC3 and disease?

The role of ARRDC3 in disease is still being investigated. Some studies have suggested its involvement in cardiovascular diseases, including heart failure and arrhythmias. It has also been implicated in hepatocellular carcinoma and insulin resistance. However, more research is needed to establish the exact relationship between ARRDC3 and these pathological conditions.

Can ARRDC3 interact with other proteins?

ARRDC3 has the ability to interact with various proteins, including components of the endocytic machinery, membrane receptors, and adaptor proteins. These interactions likely contribute to its role in protein trafficking and signaling pathways.

Can ARRDC3 be used as a potential therapeutic target?

The therapeutic potential of ARRDC3 is still an area of active research. Its involvement in various cellular processes and disease pathways suggests that it could be a potential target for therapeutic interventions. However, more studies are needed to uncover its precise molecular mechanisms and evaluate its viability as a therapeutic target.

Is the expression of ARRDC3 regulated by any specific factors?

The regulation of ARRDC3 expression is not well-characterized. However, studies suggest that it can be influenced by factors such as transcriptional regulation and cellular signaling pathways. Further research is needed to understand the precise mechanisms involved in the regulation of ARRDC3 expression.