Recombinant S.cervisiae Atx1p
Cat.No. : | ATX1-438S |
Product Overview : | Recombinant S.cervisiae Atx1 copper chaperone expressed inE.coliwas cloned from S.cerevisiae cDNA. It consists of the full length Atx1 protein, residues 1-73 (swissprot accession A6ZRI4). The protein is in the apo form. MW = 8.2 kDa, |
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Cat. No. : | ATX1-438S |
Source : | Escherichia Coli. |
Purity : | > 95% by SDS-PAGE. The protein was observed as a single band migrating at a molecular weight <10 kDa. |
Supplied As : | Solution at 1 mg/ml in KH2PO4/K2HPO4 100 mM pH 7, DTT (Dithiothreitol) 1mM. The concentration is calculated from the absorbance at 280nm (e280 = 4000 M-1 cm-1). |
Characteristics : | To avoid precipitation handle the proteinin an inert atmosphere or in presence of at least 2mM DTT. Under the above conditions the product can be concentrated to a maximum of 1.5 mM. |
Storage : | -20ºC. The protein is stable at 4ºC for at least 1 week and at 25ºC for at least several hours. After initial defrost, aliquot product into individual tubes and refreeze at -20ºC. Avoid repeated freeze/defrost cycles. |
Gene Name : | Atx1p [ Saccharomyces cerevisiae ] |
Synonyms : | ATX1; Atx1p; YNL259C |
Gene ID : | 855462 |
Protein Refseq : | NP_014140 |
UniProt ID : | S47930.1 |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (6)
Ask a questionSCA1 is caused by mutations in the ATXN1 gene. The mutation resulted in the expansion of glutamine repeats in ATXN1 protein, resulting in the formation of abnormal polyglutamic acid protein. This protein abnormality can lead to abnormal neuronal function and degenerative changes, leading to the occurrence of SCA1.
Yes, the ATXN1 protein interacts with multiple proteins to form complexes involved in the regulation of a variety of cellular functions. For example, ATXN1 interacts with the Capicua (CIC) protein and is involved in transcriptional regulation.
The protein is associated with spinocerebellar ataxia type 1 (SCA1). SCA1 is an inherited neurodegenerative disease characterized by dysfunction of the cerebellum and spinal cord, leading to ataxia and other neurological symptoms.
ATXN1 protein is expressed in several tissues, but its expression is higher in the central nervous system, especially in the cerebellum and spinal cord.
The function of ATXN1 protein is regulated by a variety of regulatory mechanisms, including post-translational modification, assembly of protein complexes, and transcriptional regulation. These regulatory mechanisms ensure the adaptability and stability of ATXN1 protein.
ATXN1 protein is involved in the regulation of a variety of neural cell functions, including cell cycle regulation, DNA repair, transcription regulation, etc. It plays an important role in the development and functional maintenance of the nervous system.
Customer Reviews (3)
Write a reviewUsing Atxn1 as a catalyst, the rate and yield of chemical reactions can be significantly increased, and the catalytic efficiency is very high.
The stability of Atxn1 is very good, and its structure and function remain stable even after several freeze-thaw cycles, which shows its excellent quality control and production process.
Atxn1 are so simple to prepare that we can easily prepare them ourselves.
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