Other Hematopoietic Stem Cell Growth Factors
About Other Hematopoietic Stem Cell Growth Factors
IL-3, SCF, Flt-3 ligand, and M-CSF are several hematopoietic stem cell growth factors that play crucial roles in the regulation and development of hematopoietic stem cells (HSC).
IL-3 (Interleukin-3) is a multifunctional cytokine. It is mainly produced by activated T cells and other immune cells, stimulates the proliferation and differentiation of hematopoietic stem cells, and promotes the development of cell lineages such as granulocytes, monocytes, and macrophages. In addition, IL-3 is involved in the functional regulation of immune cells and inflammatory responses.
SCF (stem cell factor), also known as steel factor or c-Kit ligand, is a key regulator of HSC self-renewal, proliferation, and differentiation. It is produced by bone marrow mesenchymal stromal cells, fibroblasts, and other cells. It promotes the proliferation and survival of hematopoietic stem cells, as well as the development of several cell lineages (including granulocytes, erythrocytes, macrophages, and myeloid stromal cells, among others) by binding to the c-Kit receptor.
Flt-3 ligand (Fms-like tyrosine kinase 3 ligand) is a cytokine that binds to the Flt-3 receptor and regulates the proliferation and differentiation of hematopoietic stem cells. It is mainly produced by bone marrow mesenchymal stromal cells and T cells.Flt-3 ligand promotes the proliferation and development of hematopoietic stem cells, especially lymphoid and myeloid precursor cells such as lymphocytes and macrophage precursors, by binding to the Flt-3 receptor.
M-CSF (macrophage colony-stimulating factor), also known as CSF-1, is an important hematopoietic cell growth factor produced primarily by bone marrow mesenchymal stromal cells and some other cell types. It primarily regulates the proliferation, differentiation, and survival of monocytes and macrophages, and also acts on HSCs and other progenitor cells to enhance their survival and promote bone marrow lineage differentiation. In addition, M-CSF plays an important role in the formation and maintenance of the bone marrow microenvironment.
These hematopoietic stem cell growth factors, including IL-3, SCF, Flt-3 ligand, and M-CSF, work synergistically to maintain hematopoietic homeostasis and ensure the normal production of various blood cell types. They play critical roles in normal hematopoiesis as well as under conditions of stress or injury, making them valuable targets for hematopoietic disorder research and potential therapeutic interventions.
Available Resources of Other Hematopoietic Stem Cell Growth Factors
At Creative BioMart, we offer a comprehensive range of research tools and services to support studies related to other hematopoietic stem cell growth factors, including recombinant proteins, cell and tissue solutions, transfected stable cell lines, GMP proteins, protein pre-coupled magnetic beads, chromatography reagents, native proteins, antibodies, and other assay kits. The following other hematopoietic stem cell growth factors are displayed, click to view all related molecules/targets and research reagents. Please feel free to contact us with any questions or requests.
