BIRC3

Official Full Name

baculoviral IAP repeat containing 3

Background

This gene encodes a member of the IAP family of proteins that inhibit apoptosis by binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2, probably by interfering with activation of ICE-like proteases. The encoded protein inhibits apoptosis induced by serum deprivation but does not affect apoptosis resulting from exposure to menadione, a potent inducer of free radicals. It contains 3 baculovirus IAP repeats and a ring finger domain. Transcript variants encoding the same isoform have been identified.

Synonyms

BIRC3; baculoviral IAP repeat containing 3; API2, baculoviral IAP repeat containing 3; baculoviral IAP repeat-containing protein 3; apoptosis inhibitor 2; c IAP2; cIAP2; hiap 1; inhibitor of apoptosis protein 1; MALT2; mammalian IAP homolog C; MIHC; RNF49; TNFR2 TRAF signaling complex protein; CIAP 2; AIP 1; AIP1; API 2; API2; Baculoviral IAP repeat containing protein 3; BIRC 3; BIRC3_HUMAN; C-IAP2; HAIP 1; HAIP1; HIAP-1; HIAP1; IAP homolog C; IAP-1; MALT 2; RING finger protein 49; TNFR2 TRAF signaling complex protein 1; TNFR2 TRAF signalling complex protein; TNFR2-TRAF-signaling complex protein 1; baculoviral IAP repeat-containing 3; TNFR2-TRAF signaling complex protein