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DICER1

  • Official Full Name

    dicer 1, ribonuclease type III

  • Overview

    This gene encodes a protein possessing an RNA helicase motif containing a DEXH box in its amino terminus and an RNA motif in the carboxy terminus. The encoded protein functions as a ribonuclease and is required by the RNA interference and small temporal RNA (stRNA) pathways to produce the active small RNA component that represses gene expression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2010]
  • Synonyms

    DICER1; dicer 1, ribonuclease type III; DCR1; MNG1; Dicer; HERNA; RMSE2; endoribonuclease Dicer; K12H4.8-LIKE; helicase MOI; helicase-moi; Dicer1, Dcr-1 homolog; multinodular goitre 1; helicase with RNAse motif; dicer 1, double-stranded RNA-specific endoribonuclease; DCR-1; Dicer-1; CG4792 gene product from transcript CG4792-RA; Dicer 1 ribonuclease type III; Dicer-1 protein; DICER_HUMAN; Endoribonuclease Dcr-1; ORFNames: CG4792; CG4792-PA; Dcr-1-PA; cg4792; Dcr; dcr 1; Dmel\CG4792; Antagonist decoy receptor for TRAIL/Apo 2L; CD263; Cytotoxic TRAIL receptor 3; DCR1 TNFR; Dctrailr1; Decoy Receptor 1; Decoy TRAIL receptor 1; Decoy TRAIL receptor without death domain; LIT; Lymphocyte inhibitor of TRAIL; MGC149501; MGC149502; mSOB; TNF receptor family member SOB; TNF receptor homolog 1; TNF Related Apoptosis Inducing Ligand Receptor 3; TNF-re ated apoptosis inducing ligand receptor 3; Tnfrh1; TNFRSF10C; Tnfrsf1al1; Tnfrsf23; TRAIL R3; TRAIL receptor 3; TRAIL Receptor Without An Intracellular Domain; TRAILR3; TRID; Tumor necrosis factor receptor p60 homolog 1; Tumor Necrosis Factor Receptor Superfamily Member 10C; Tumor necrosis factor receptor superfamily member 23; Tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • Human cells
  • Mamanlian cells
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • DYKDDDDK
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • Myc|DDK
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human DICER1-4738H Recombinant Human DICER1, GST-tagged Wheat Germ GST
Human DICER1-784H Recombinant Human DICER1 protein, MYC/DDK-tagged HEK293 Myc/DDK
Human DICER1-33H Recombinant Human DICER1 protein, MYC/DDK-tagged HEK293 Myc/DDK
Human DICER1-28329TH Recombinant Human DICER1, His-tagged E.coli His
Human DICER1-1971H Recombinant Human DICER1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human DICER1-01H Recombinant Human DICER1 Protein, DYKDDDDK-tagged Human cells DYKDDDDK
Human DICER1-1088H Recombinant Human DICER1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human DICER1-1780H Recombinant Human DICER1 protein, His-tagged E.coli His Leu6~Ser290
Human DICER1-762H Recombinant Human DICER1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human DICER1-2435HFL Recombinant Full Length Human DICER1 protein, Flag-tagged Mamanlian cells Flag
Human DICER1-762H-B Recombinant Human DICER1 Protein Pre-coupled Magnetic Beads HEK293
Human DICER1-1120HFL Recombinant Full Length Human DICER1 Protein, C-Flag-tagged Mammalian cells Flag
Rhesus Macaque DICER1-1265R Recombinant Rhesus monkey DICER1 Protein, His-tagged Mammalian Cell His
Rhesus Macaque DICER1-1090R-B Recombinant Rhesus Macaque DICER1 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque DICER1-1090R Recombinant Rhesus Macaque DICER1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish DICER1-7503Z Recombinant Zebrafish DICER1 Mammalian Cell His
Chicken DICER1-3414C Recombinant Chicken DICER1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • DICER1 Related Articles
  • DICER1 Related Research Area

DICER1 involved in several pathways and played different roles in them. We selected most pathways DICER1 participated on our site, such as MicroRNAs in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with DICER1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
MicroRNAs in cancerEZH2;NRAS;PIK3R2;PDGFB;PRKCE;MAPK7;VIM;PIK3CA;NOTCH2

DICER1 has several biochemical functions, for example, ATP binding, DNA binding, deoxyribonuclease I activity. Some of the functions are cooperated with other proteins, some of the functions could acted by DICER1 itself. We selected most functions DICER1 had, and list some proteins which have the same functions with DICER1. You can find most of the proteins on our site.

Function Related Protein
ATP bindingNLRC5;GATB;LATS2;MAPK14B;DAPK2;ATP5B;CKMT2A;ADCK3;CDK20
DNA bindingCLOCKA;ZNF32;ZFP36L3;POGZ;ZSCAN18;RIMKLB;ZFP410;HIST2H2BE;TA
deoxyribonuclease I activityDNASE1;DICER1
double-stranded RNA bindingSTRBP;OASL;MYH4;IFIH1;ZFP346;HSPD1;TLR8;AGO2;EIF2C3
endoribonuclease activityPLD6;TSN;DROSHA;RNASEL;DICER1;ENDOU2;AGO2;CPSF3;ERN1
helicase activityHELQ;DDX11;DNA2;DDX52;HELZ;HLTF;DHX36;PIF1;MCM8
metal ion bindingLNPB;ING5A;ZNF80;ZNF174;ALOX8;MYLIPA;SNAI1A;ATF2;HNRNPA0L
miRNA bindingEIF2C3;TARBP2;RBM4;LIN28A;AGO4;DICER1;TRIM71;AGO1;AGO2
pre-miRNA bindingDICER1;TARBP2;XPO5
contributes_to pre-miRNA bindingRAN;DICER1;TARBP2;XPO5
protein bindingHDAC5;PCDHA4;TEAD4;MST1R;RPL28;ATP2A1;MAPK11;HACL1;MYOCD
protein domain specific bindingVPS4A;MECP2;MYH9;MPP5;CALM;PLG;IST1;ICAL1;HIST2H4A
ribonuclease III activityMRPL44;BARHL1;DICER1;DROSHA;RNASEN;AGFG1A
siRNA bindingMECP2;DICER1;TLR7;TLR9;AGO2;TARBP2

DICER1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DICER1 here. Most of them are supplied by our site. Hope this information will be useful for your research of DICER1.

AGO2; TARBP2

Devouassoux-Shisheboran, M; et al. Ovarian cancer: molecular biology. ONCOLOGIE 16:306-312(2014).
Stewart, CJR; Alexiadis, M; et al. An immunohistochemical and molecular analysis of problematic and unclassified ovarian sex cord stromal tumors. HUMAN PATHOLOGY 44:2774-2781(2013).
  • Q&As
  • Reviews

Q&As (5)

Ask a question
Can DICER1 mutations affect non-cancer-related health conditions? 07/21/2021

DICER1 mutations may also lead to non-cancer conditions, such as pleuropulmonary blastoma syndrome and cystic nephroma.

Is there any potential for using DICER1 in targeted cancer therapies? 06/23/2021

Research is ongoing to explore whether targeting DICER1-related pathways could lead to novel cancer treatments.

Are there any clinical tests or assays that measure DICER1 levels in patients? 01/21/2020

Yes, some diagnostic tests can measure DICER1 expression, which may be relevant in certain cancer types.

Can DICER1 mutations be hereditary? 02/09/2019

Yes, DICER1 mutations can be passed down through families and cause a hereditary predisposition to certain cancers.

How is DICER1 involved in cancer development and progression? 03/09/2018

DICER1 mutations or dysregulation can lead to abnormal microRNA processing, contributing to the development of cancer.

Customer Reviews (3)

Write a review
Reviews
04/26/2023

    Its purity and functional integrity guarantee optimal performance in a wide range of experimental applications.

    10/26/2018

      Their team of experts is readily available to assist you with any inquiries or challenges you may encounter during your experiments.

      03/28/2018

        This protein, manufactured with utmost precision, provides reliable and consistent results, ensuring the accuracy and reproducibility of your research findings.

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