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DVL1

Official Full Name

dishevelled, dsh homolog 1 (Drosophila)
Overview

DVL1, the human homolog of the Drosophila dishevelled gene (dsh) encodes a cytoplasmic phosphoprotein that regulates cell proliferation, acting as a transducer molecule for developmental processes, including segmentation and neuroblast specification. DVL1 is a candidate gene for neuroblastomatous transformation. The Schwartz-Jampel syndrome and Charcot-Marie-Tooth disease type 2A have been mapped to the same region as DVL1. The phenotypes of these diseases may be consistent with defects which might be expected from aberrant expression of a DVL gene during development.
Synonyms

DVL1; dishevelled, dsh homolog 1 (Drosophila); dishevelled 1 (homologous to Drosophila dsh); segment polarity protein dishevelled homolog DVL-1; Dishevelled 1; dishevelled 1 like; Dishevelled; Dishevelled dsh homolog 1; Dishevelled-1; Dishevelled1; DSH homolog 1; Dvl 1; Dvl; DVL1_HUMAN; DVL1L1; MGC54245; Segment polarity protein dishevelled homolog DVL 1; segment polarity protein dishevelled homolog DVL 1 like; Segment polarity protein dishevelled homolog DVL1;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse
Rat

Source

E.coli
HEK293
In Vitro Cell Free System
Mammalian Cell
Wheat Germ

Tag

GST
His
His (Fc)
Avi
His|T7
N/A
N

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	DVL1-2959H	Recombinant Human DVL1 Protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	DVL1-28351TH	Recombinant Human DVL1	Wheat Germ	N/A	110 amino acids	Inquiry
Human	DVL1-6766HCL	Recombinant Human DVL1 293 Cell Lysate	HEK293	N/A		Inquiry
Human	DVL1-1682H	Recombinant Human DVL1 protein, His & T7-tagged	E.coli	His/T7	Arg150~Lys285 (Accession # O14640)	Inquiry
Human	DVL1-4135HF	Recombinant Full Length Human DVL1 Protein, GST-tagged	In Vitro Cell Free System	GST	444 amino acids	Inquiry
Human	DVL1-2011H	Recombinant Human DVL1 Protein (Arg150-Lys285), N-His tagged	E.coli	N-His	Arg150-Lys285	Inquiry
Mouse	DVL1-4899M	Recombinant Mouse DVL1 Protein	Mammalian Cell	His		Inquiry
Mouse	DVL1-2574M	Recombinant Mouse DVL1 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Mouse	Dvl1-1683M	Recombinant Mouse Dvl1 protein, His & T7-tagged	E.coli	His/T7	Arg150~Ser332 (Accession # P51141)	Inquiry
Mouse	DVL1-2574M-B	Recombinant Mouse DVL1 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Rat	DVL1-1980R	Recombinant Rat DVL1 Protein	Mammalian Cell	His		Inquiry
Rat	DVL1-1638R-B	Recombinant Rat DVL1 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Rat	DVL1-1638R	Recombinant Rat DVL1 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry

Involved Pathway
Protein Function
Interacting Protein
Other Resource
DVL1 Related Signal Pathway

DVL1 involved in several pathways and played different roles in them. We selected most pathways DVL1 participated on our site, such as Adipogenesis, Basal cell carcinoma, Beta-catenin independent WNT signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with DVL1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Adipogenesis	FOXC2;CEBPA;EGR2;AGT;KLF7A;BSCL2;NRIP1;NDN;BMP1
Basal cell carcinoma	STK36;WNT10B;TRP53;Shh;WNT7B;WNT7A;SMO;TCF7L2;FZD8
Beta-catenin independent WNT signaling	ROR1;DVL1;AGO3;ROR2;PRICKLE1B;AGO1;AP2A2;AGO2;RYK
Canonical Wnt signaling pathway	CSNK1D;CSNK1E;CSNK1A1;KLHL12;DVL3;DVL1;DVL2
DNA damage response (only ATM dependent)	DVL3;DVL1;BIK;MLKL;DVL2
Degradation of DVL	KLHL12;DVL2;DACT1;DVL1;HECW1B;HECW1;DVL3
Disassembly of the destruction complex and recruitment of AXIN to the membrane	DVL3;DVL2;DVL1;CSNK1G2;WNT8-2
HTLV-I infection	ANAPC2;HLA-DRB5;PRKACB;EGR1;MAP2K4;IL15RA;WNT9B;KAT2B;Adcy4

DVL1 has several biochemical functions, for example, Rac GTPase binding, enzyme binding, frizzled binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DVL1 itself. We selected most functions DVL1 had, and list some proteins which have the same functions with DVL1. You can find most of the proteins on our site.

Function	Related Protein
Rac GTPase binding	DVL1;SOD1;DOCK4;PAK7;EPS8;CDKL5;MAP3K11;PAK4;DOCK7
enzyme binding	GSTM1;PLCB1;SRC;APBA3;HMGA1-RS1;BLZF1;CASP2;UGT1A7;UGT1A3
frizzled binding	DVL3A;WNT4B;WNT7AA;WNT11;WNT3A;BAMBI;WNT6;WNT5B;WNT8A
identical protein binding	MCIN;GRB7;FAS;VWA1;SMURF2;UGP2;ALK;EGFR;HNRNPC
molecular_function	SWT1;CCDC169;COMMD4;ZFP830;KBTBD6;SCML4;CCDC105;CX52.7;NUPR1
protein binding	AKAP12;LANCL1;CFL2;AKAP17A;KAT7;ITPR3;L3MBTL3;RAB9A;CD2BP2
protein kinase binding	USP37;AURKA;DNM2;ELAVL1;ADRA2A;SOCS1;NCS1;SLC12A4;PPP1CC

DVL1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DVL1 here. Most of them are supplied by our site. Hope this information will be useful for your research of DVL1.

Axin1; CSNK1E; DVL3

Research Area

EMT Induction

Huang, MY; Yen, LC; et al. Significant Overexpression of DVL1 in Taiwanese Colorectal Cancer Patients with Liver Metastasis. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 14:20492-20507(2013).

Lee, YN; Gao, Y; et al. Differential mediation of the Wnt canonical pathway by mammalian Dishevelleds-1,-2, and-3. CELLULAR SIGNALLING 20:443-452(2008).