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DVL1

  • Official Full Name

    dishevelled, dsh homolog 1 (Drosophila)

  • Overview

    DVL1, the human homolog of the Drosophila dishevelled gene (dsh) encodes a cytoplasmic phosphoprotein that regulates cell proliferation, acting as a transducer molecule for developmental processes, including segmentation and neuroblast specification. DVL1 is a candidate gene for neuroblastomatous transformation. The Schwartz-Jampel syndrome and Charcot-Marie-Tooth disease type 2A have been mapped to the same region as DVL1. The phenotypes of these diseases may be consistent with defects which might be expected from aberrant expression of a DVL gene during development.
  • Synonyms

    DVL1; dishevelled, dsh homolog 1 (Drosophila); dishevelled 1 (homologous to Drosophila dsh); segment polarity protein dishevelled homolog DVL-1; Dishevelled 1; dishevelled 1 like; Dishevelled; Dishevelled dsh homolog 1; Dishevelled-1; Dishevelled1; DSH homolog 1; Dvl 1; Dvl; DVL1_HUMAN; DVL1L1; MGC54245; Segment polarity protein dishevelled homolog DVL 1; segment polarity protein dishevelled homolog DVL 1 like; Segment polarity protein dishevelled homolog DVL1;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • E.coli
  • HEK293
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • His|T7
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human DVL1-2959H Recombinant Human DVL1 Protein, GST-tagged Wheat Germ GST
Human DVL1-28351TH Recombinant Human DVL1 Wheat Germ N/A 110 amino acids
Human DVL1-6766HCL Recombinant Human DVL1 293 Cell Lysate HEK293 N/A
Human DVL1-1682H Recombinant Human DVL1 protein, His & T7-tagged E.coli His/T7 Arg150~Lys285 (Accession # O14640)
Human DVL1-4135HF Recombinant Full Length Human DVL1 Protein, GST-tagged In Vitro Cell Free System GST 444 amino acids
Human DVL1-2011H Recombinant Human DVL1 Protein (Arg150-Lys285), N-His tagged E.coli N-His Arg150-Lys285
Mouse DVL1-4899M Recombinant Mouse DVL1 Protein Mammalian Cell His
Mouse DVL1-2574M Recombinant Mouse DVL1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Dvl1-1683M Recombinant Mouse Dvl1 protein, His & T7-tagged E.coli His/T7 Arg150~Ser332 (Accession # P51141)
Mouse DVL1-2574M-B Recombinant Mouse DVL1 Protein Pre-coupled Magnetic Beads HEK293
Rat DVL1-1980R Recombinant Rat DVL1 Protein Mammalian Cell His
Rat DVL1-1638R-B Recombinant Rat DVL1 Protein Pre-coupled Magnetic Beads HEK293
Rat DVL1-1638R Recombinant Rat DVL1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • DVL1 Related Articles
  • DVL1 Related Research Area
  • DVL1 Related Signal Pathway

DVL1 involved in several pathways and played different roles in them. We selected most pathways DVL1 participated on our site, such as Adipogenesis, Basal cell carcinoma, Beta-catenin independent WNT signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with DVL1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
AdipogenesisEGR2B;DLK1;SMAD3B;NDN;CREB1;FOXC2;CTNNB1;KLF6A;AHR
Basal cell carcinomaWNT5A;HHIP;WNT6;WNT9A;SETD6;AXIN2;TP53;AXIN1;FZD1
Beta-catenin independent WNT signalingAGO1;CTNNB2;MOV10;DVL2;AGO3;AP2M1;GNB5;CLTB;DVL3
Canonical Wnt signaling pathwayCSNK1E;DVL2;DVL3;DVL1;CSNK1D;CSNK1A1;KLHL12
DNA damage response (only ATM dependent)BIK;DVL1;DVL3;MLKL;DVL2
Degradation of DVLHECW1;DVL3;KLHL12;DVL1;DVL2;DACT1;HECW1B
Disassembly of the destruction complex and recruitment of AXIN to the membraneDVL3;WNT8-2;CSNK1G2;DVL1;DVL2
HTLV-I infectionTBPL2;DVL2;WNT5B;ITGAL;PIK3CB;HLA-DMB;CD3D;Pdgfa&Pdgfb;MAPK8

DVL1 has several biochemical functions, for example, Rac GTPase binding, enzyme binding, frizzled binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DVL1 itself. We selected most functions DVL1 had, and list some proteins which have the same functions with DVL1. You can find most of the proteins on our site.

Function Related Protein
Rac GTPase bindingDVL1;SRGAP2A;NCF2;RCC2;RAB7;OCRL;HACE1;EPS8;FLNA
enzyme bindingYWHAB;LAMB1;NPC2;NOTCH1;PEX5;SUDS3;GSTM1;PIAS1;APOA5
frizzled bindingWNT1;WNT8A;RNF43;RSPO3;WNT4;WNT3A;WNT8B;WNT11R;WNT9B
identical protein bindingLZTFL1;STIM1;BNIP3L;S100B;PDCD6;DIAPH1;RIPK3;HSPB1;CDC42
molecular_functionGM7861;TMEM237B;TMEM233;DUB;HDHD1A;SLC35F2;ARHGAP42;CRYBA1A;IGSF3
protein bindingODC1;ZNF131;SERPINB1A;NUBP2;TOMM20;CTNNA3;RAB43;BSCL2;SHFM1
protein kinase bindingLCK;DNAJC3;SCN5A;CCND2;RCC2;MAP2K7;KIF11;DNM1;BORA

DVL1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DVL1 here. Most of them are supplied by our site. Hope this information will be useful for your research of DVL1.

Axin1; CSNK1E; DVL3

Huang, MY; Yen, LC; et al. Significant Overexpression of DVL1 in Taiwanese Colorectal Cancer Patients with Liver Metastasis. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 14:20492-20507(2013).
Lee, YN; Gao, Y; et al. Differential mediation of the Wnt canonical pathway by mammalian Dishevelleds-1,-2, and-3. CELLULAR SIGNALLING 20:443-452(2008).
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