Background
The neurotransmitter serotonin (5-hydroxytryptamine; 5-HT) exerts a wide variety of physiologic functions through a;multiplicity of receptors and may be involved in human neuropsychiatric disorders such as anxiety, depression, or;migraine. These receptors consist of several main groups subdivided into several distinct subtypes on the basis of;their pharmacologic characteristics, coupling to intracellular second messengers, and distribution within the nervous;system (Zifa and Fillion, 1992 (PubMed 1359584)). The serotonergic receptors belong to the multigene family of;receptors coupled to guanine nucleotide-binding proteins.