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KRT18

  • Official Full Name

    keratin 18

  • Overview

    KRT18 encodes the type I intermediate filament chain keratin 18. Keratin 18, together with its filament partner keratin 8, are perhaps the most commonly found members of the intermediate filament gene family. They are expressed in single layer epithelial tissues of the body. Mutations in this gene have been linked to cryptogenic cirrhosis. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
  • Synonyms

    KRT18; keratin 18; K18; CYK18; keratin, type I cytoskeletal 18; CK-18; keratin-18; cytokeratin 18; cytokeratin-18; cell proliferation-inducing protein 46; cell proliferation-inducing gene 46 protein;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Native Proteins
  • Bovine
  • Human
  • Mouse
  • Pig
  • Rat
  • Zebrafish
  • bovine liver
  • E. coli
  • E.coli
  • HEK293
  • In Vitro Cell Free System
  • Insect Cell
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • His|T7
  • N/A
  • N
  • T7|His|TEV cleavage site
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human KRT18-12H Recombinant Human KRT18 protein, His-tagged E.coli His
Human KRT18-266H Recombinant Human Cytokeratin-18 , His-tagged E.coli His
Human KRT18-174H Recombinant Human KRT18 Protein, His-tagged E.coli His Ser2~His430
Human KRT18-464H Recombinant Human Keratin 18 E.coli N/A
Human KRT18-13H Recombinant Human KRT18 protein, T7/His-tagged E.coli T7/His/TEV cleavage site 1 a.a. - 100 a.a.
Human KRT18-27702TH Recombinant Human KRT18, His-tagged E.coli His
Human KRT18-4877HCL Recombinant Human KRT18 293 Cell Lysate HEK293 N/A
Human KRT18-4876HCL Recombinant Human KRT18 293 Cell Lysate HEK293 N/A
Human KRT18-487H Recombinant Human KRT18 protein, GST-tagged E. coli GST 127-430 aa
Human KRT18-4867H Recombinant Human KRT18 Protein, GST-tagged Wheat Germ GST
Human KRT18-4348H Recombinant Human KRT18 protein, His-tagged Insect Cell His 2-430aa
Human KRT18-3146H Recombinant Human KRT18 protein, His-tagged E.coli His 11-430aa
Human KRT18-5030H Recombinant Human KRT18 protein, His-tagged HEK293 His 2-430aa
Human KRT18-4393H Recombinant Human KRT18 Protein (Asp238-Leu396), N-His tagged E.coli N-His Asp238-Leu396
Human KRT18-3147H Recombinant Human KRT18 protein, His-tagged E.coli His 102-396aa
Human KRT18-3148H Recombinant Human KRT18 protein E.coli N/A 2-430aa
Human KRT18-5928HF Recombinant Full Length Human KRT18 Protein, GST-tagged In Vitro Cell Free System GST 430 amino acids
Human KRT18-1075H Recombinant Human KRT18 Protein, His-tagged E.coli N-His Ser2-His430
Human KRT18-1585HFL Recombinant Full Length Human KRT18 Protein, N-His-tagged E.coli His
Mouse KRT18-1745M Active Recombinant Mouse Krt18 Protein, His-tagged E.coli His
Mouse KRT18-8821M Recombinant Mouse KRT18 Protein Mammalian Cell His
Mouse Krt18-5841M Recombinant Mouse Krt18 protein, His-tagged E.coli His Met1~His423 (Accession # P05784)
Mouse KRT18-4914M Recombinant Mouse KRT18 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse KRT18-4914M-B Recombinant Mouse KRT18 Protein Pre-coupled Magnetic Beads HEK293
Rat KRT18-3315R Recombinant Rat KRT18 Protein Mammalian Cell His
Rat Krt18-5843R Recombinant Rat Krt18 protein, His-tagged E.coli His Glu72~Gly380
Rat KRT18-2971R-B Recombinant Rat KRT18 Protein Pre-coupled Magnetic Beads HEK293
Rat KRT18-2971R Recombinant Rat KRT18 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Bovine KRT18-173B Native bovine KRT18 bovine liver N/A
Zebrafish KRT18-9605Z Recombinant Zebrafish KRT18 Mammalian Cell His
Pig KRT18-5842P Recombinant Pig KRT18 protein, His & T7-tagged E.coli His/T7 Arg1~Thr159 (Accession # A8D349)
  • Involved Pathway
  • Protein Function
  • Interacting Protein

KRT18 involved in several pathways and played different roles in them. We selected most pathways KRT18 participated on our site, such as Pathogenic Escherichia coli infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with KRT18 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Pathogenic Escherichia coli infectionCDH1;HCLS1;WASL;ROCK2;NCK1;TUBA1C;TUBA3E;FYN;ABL1

KRT18 has several biochemical functions, for example, poly(A) RNA binding, protein binding, scaffold protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by KRT18 itself. We selected most functions KRT18 had, and list some proteins which have the same functions with KRT18. You can find most of the proteins on our site.

Function Related Protein
poly(A) RNA bindingTPR;NOVA1;PSMD4;TBCA;RPUSD3;CHTOP;TARDBP;CELF1;HDLBP
protein bindingCTSK;PCBD1;MRPL48;BUD13;HIST1H3G;MRPL27;RIMS2;CTSG;MGAT5B
scaffold protein bindingIKBKB;CIT;P2RY1;SRC;NLGN4Y;CASP8;GRIN2A;PARK7;DLG4
structural molecule activityKRT26;CLDN15LA;IVL;KRT86;COPE;CLTB;KRT28;SNTB1;CLDN15B

KRT18 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KRT18 here. Most of them are supplied by our site. Hope this information will be useful for your research of KRT18.

KRT8; YWHAZ; DNAJB6; TRADD

  • Q&As
  • Reviews

Q&As (6)

Ask a question
What is the relationship between KRT18 protein and nail diseases? 10/23/2022

KRT18 protein may be associated with nail diseases, such as brittle nails, white spots, and longitudinal cracks. These diseases can affect the hardness and structure of the nails, causing them to appear brittle, deformed, and painful.

What is the relationship between KRT18 protein and hair color? 06/15/2022

KRT18 protein is not directly related to hair color. Hair color is mainly determined by melanocytes, while the KRT18 protein is mainly involved in the process of keratinization.

How can genetic testing be used to understand the genetic variation of KRT18 protein? 04/01/2022

Genetic testing can be done by analyzing DNA sequences to understand genetic variation in the KRT18 protein. These variants may affect the expression level and function of the KRT18 protein, thereby increasing the risk of certain diseases.

How can lifestyle changes affect the function of KRT18 protein? 01/21/2021

Lifestyle changes, such as eating a healthy diet, exercising moderately, and avoiding UV damage, can affect the function and expression levels of KRT18 protein. These alterations can promote the normal function of keratinocytes, which can help maintain healthy skin.

How can KRT18 protein-related diseases be prevented? 08/15/2020

Prevention of KRT18 protein-related diseases is mainly through maintaining a healthy lifestyle, such as a balanced diet, moderate exercise, maintaining water intake, and avoiding UV damage. In addition, regular skin and oral exams can also help detect potential problems early.

What is the role of KRT18 protein in melanoma? 03/13/2020

In melanoma, the KRT18 protein may play a role in promoting tumor growth and metastasis. This may be related to the proliferation and migration of melanoma cells.

Customer Reviews (3)

Write a review
Reviews
01/17/2022

    The sensitivity is very high, the experimental results are very good, and the unnecessary trouble is reduced.

    10/31/2021

      No doping impurities, the experimental effect is very good, will be recommended to other laboratory students.

      01/03/2021

        Easy to operate, cost-effective.

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