ADCK2
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Official Full Name
aarF domain containing kinase 2
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Synonyms
ADCK2; aarF domain containing kinase 2; uncharacterized aarF domain-containing protein kinase 2; MGC20727; putative ubiquinone biosynthesis protein AarF; AARF;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Homo sapiens (Human)
- Human
- Mouse
- E.coli
- E.coli expression system
- HEK293
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- Yeast
- GST
- His
- His (Fc)
- Avi
- His|SUMO
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
ADCK2 involved in several pathways and played different roles in them. We selected most pathways ADCK2 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with ADCK2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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ADCK2 has several biochemical functions, for example, ATP binding, protein serine/threonine kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ADCK2 itself. We selected most functions ADCK2 had, and list some proteins which have the same functions with ADCK2. You can find most of the proteins on our site.
Function | Related Protein |
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ATP binding | SYN2A;EPHA4A;ACTR2;ABCB4;DMPK;RAD50;KIF21A;RAD54B;BRAF |
protein serine/threonine kinase activity | GSK3B;MAST4;WNK1;SGK2;NEK3;TGFBR1A;OXSR1B;CDKL5;HUNK |
ADCK2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ADCK2 here. Most of them are supplied by our site. Hope this information will be useful for your research of ADCK2.
- Q&As
- Reviews
Q&As (13)
Ask a questionMutations in ADCK2 are associated with various diseases, including primary and secondary CoQ10 deficiencies, cerebellar ataxia, and steroid-resistant nephrotic syndrome. These mutations can affect the enzyme's ability to phosphorylate the intermediate compound in the CoQ10 biosynthesis pathway, leading to reduced levels of CoQ10 in tissues and cells. As CoQ10 plays important roles in energy production and protection against oxidative stress, CoQ10 deficiency can result in a range of symptoms, including muscle weakness, neurological problems, and kidney dysfunction.
Some studies have investigated ADCK2 protein levels as a potential biomarker for CoQ10 deficiency, but the results have been mixed and more research is needed to determine whether ADCK2 levels could be used for diagnostic or prognostic purposes. Additionally, ADCK2 mutations have been associated with several diseases, so testing for these mutations may be a useful diagnostic tool in certain populations.
While there are currently no specific drugs targeting ADCK2 protein, the regulation of the CoQ10 biosynthesis pathway and its involvement in various diseases suggest that ADCK2 protein may be a useful target for drug development. Compounds that can increase CoQ10 biosynthesis or protect against oxidative stress may be potential therapeutic agents for diseases associated with CoQ10 deficiency.
The use of ADCK2 protein as a therapeutic agent has not been extensively studied, so there may be potential risks and side effects that are not yet known.
There is currently no specific drug targeting ADCK2 protein for therapeutic interventions. However, CoQ10 supplementation is widely used to treat CoQ10 deficiency-related disorders, and some studies have investigated compounds that can increase CoQ10 biosynthesis or protect against oxidative stress as potential therapeutic agents. Modulating the expression or activity of other proteins involved in the CoQ10 biosynthesis pathway may also be a potential strategy for increasing CoQ10 levels in cells or tissues.
The potential therapeutic applications of ADCK2 protein are not well understood. However, ADCK2 protein has been linked to several metabolic pathways, including CoQ10 biosynthesis, suggesting that it may be a potential therapeutic target for conditions related to CoQ10 deficiency.
There is limited research on the effects of exercise on ADCK2 protein levels, but some studies have suggested that exercise may help maintain mitochondrial function and reduce oxidative stress, which could potentially affect ADCK2 expression. However, more research is needed to confirm these findings.
The regulation of ADCK2 expression in the body is not yet fully understood, but some studies have suggested that dietary intake may play a role. For example, a diet high in fruits and vegetables, which are rich in antioxidants, may help protect against oxidative stress and maintain mitochondrial function, possibly affecting ADCK2 protein levels.
The regulation of ADCK2 expression in the body is not yet fully understood. Some studies have suggested that ADCK2 expression may be regulated by a transcription factor called Nrf2, which is involved in the cellular stress response and plays a role in maintaining mitochondrial function. Other studies have found that ADCK2 expression may be affected by a variety of other factors, such as dietary intake, aging, and exercise, but more research is needed to confirm these findings.
One potential application of ADCK2 protein is as a therapeutic target for the treatment of diseases associated with CoQ10 deficiency, such as primary and secondary CoQ10 deficiencies, cerebellar ataxia, and steroid-resistant nephrotic syndrome. In addition, ADCK2 protein levels or mutations may be useful biomarkers for diagnostic or prognostic purposes in certain populations.
Yes, diagnostic tests are available for ADCK2 mutations. These tests can be used to identify mutations associated with diseases such as cerebellar ataxia and steroid-resistant nephrotic syndrome.
There are currently no clinical trials underway that focus on ADCK2 protein. However, there are ongoing studies investigating CoQ10 supplementation in various conditions, including heart disease and neurodegenerative disorders.
ADCK2 protein levels may provide indirect information about CoQ10 levels in the body, but it is not a direct diagnostic tool for CoQ10 deficiency. Diagnosis of CoQ10 deficiency usually requires specific tests that measure CoQ10 levels in blood or tissues.
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