ALG1
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Official Full Name
asparagine-linked glycosylation 1, beta-1,4-mannosyltransferase homolog (S. cerevisiae)
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Overview
The enzyme encoded by this gene catalyzes the first mannosylation step in the biosynthesis of lipid-linked oligosaccharides. This gene is mutated in congenital disorder of glycosylation type Ik. -
Synonyms
ALG1; asparagine-linked glycosylation 1, beta-1,4-mannosyltransferase homolog (S. cerevisiae); asparagine linked glycosylation 1 homolog (yeast, beta 1,4 mannosyltransferase); chitobiosyldiphosphodolichol beta-mannosyltransferase; HMAT1; HMT 1; 4-mannosyltransferase; ALG1_HUMAN; asparagine-linked glycosylation 1 homolog (yeast, beta-1,4-mannosyltransferase); Asparagine-linked glycosylation protein 1 homolog; Beta 1 4 mannosyltransferase; Beta-1; CDG1K; GDP Man GlcNAc2 PP dolichol mannosyltransferase; GDP-Man:GlcNAc2-PP-dolichol mannosyltransferase; GDP-mannose-dolichol diphosphochitobiose mannosyltransferase; Hmat-1; HMT1; Mannosyltransferase 1; Mannosyltransferase-1; MT 1; MT-1; MT1; OTTHUMP00000159923; beta-1,4 mannosyltransferase; beta-1,4-mannosyltransferase; HMT-1; Mat-1;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii)
- Dictyostelium discoideum (Slime mold)
- Human
- Mouse
- Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
- Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
- Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
- Zebrafish
- E.coli
- E.coli expression system
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- Myc
- DDK
- N/A
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
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Human | ALG1-459H | Recombinant Human ALG1 Protein, GST-tagged | Wheat Germ | GST | ||
Human | ALG1-771H | Recombinant Human ALG1 | Mammalian Cell | His | ||
Human | ALG1-9569H | Recombinant Human ALG1, GST-tagged | E.coli | GST | C-term-308a.a. | |
Human | ALG1-8909HCL | Recombinant Human ALG1 293 Cell Lysate | HEK293 | N/A | ||
Human | ALG1-2454H | Recombinant Human ALG1 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Human | ALG1-1426HF | Recombinant Full Length Human ALG1 Protein, GST-tagged | In Vitro Cell Free System | GST | 464 amino acids | |
Human | ALG1-2454H-B | Recombinant Human ALG1 Protein Pre-coupled Magnetic Beads | HEK293 | |||
Mouse | ALG1-1540M | Recombinant Mouse ALG1 Protein | Mammalian Cell | His | ||
Mouse | ALG1-461M | Recombinant Mouse ALG1 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Mouse | ALG1-461M-B | Recombinant Mouse ALG1 Protein Pre-coupled Magnetic Beads | HEK293 | |||
Mouse | Alg1-1597M | Recombinant Mouse Alg1 Protein, Myc/DDK-tagged | HEK293T | Myc/DDK | ||
Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii) | RFL35868DF | Recombinant Full Length Debaryomyces Hansenii Chitobiosyldiphosphodolichol Beta-Mannosyltransferase(Alg1) Protein, His-Tagged | E.coli expression system | His | Full Length (1-472) | |
Dictyostelium discoideum (Slime mold) | RFL-7530DF | Recombinant Full Length Dictyostelium Discoideum Chitobiosyldiphosphodolichol Beta-Mannosyltransferase(Alg1) Protein, His-Tagged | E.coli expression system | His | Full Length (1-493) | |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | RFL-21187SF | Recombinant Full Length Saccharomyces Cerevisiae Chitobiosyldiphosphodolichol Beta-Mannosyltransferase(Alg1) Protein, His-Tagged | E.coli expression system | His | Full Length (1-449) | |
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) | RFL-25186SF | Recombinant Full Length Schizosaccharomyces Pombe Chitobiosyldiphosphodolichol Beta-Mannosyltransferase(Alg1) Protein, His-Tagged | E.coli expression system | His | Full Length (1-424) | |
Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica) | RFL28465YF | Recombinant Full Length Yarrowia Lipolytica Chitobiosyldiphosphodolichol Beta-Mannosyltransferase(Alg1) Protein, His-Tagged | E.coli expression system | His | Full Length (1-463) | |
Zebrafish | ALG1-10240Z | Recombinant Zebrafish ALG1 | Mammalian Cell | His |
- Involved Pathway
- Protein Function
- Interacting Protein
ALG1 involved in several pathways and played different roles in them. We selected most pathways ALG1 participated on our site, such as N-Glycan biosynthesis, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with ALG1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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N-Glycan biosynthesis | RABGNT1;ST6GAL2A;MAN1C1;ALG13;MGAT2;MAN1B1;ZNF408;RPN1;MGAT4A |
Metabolic pathways | CHIA.2;PTDSS2;PNP;IDS;HAO2;QDPRB1;PDHX;P4HA2;PAFAH1B1B |
ALG1 has several biochemical functions, for example, chitobiosyldiphosphodolichol beta-mannosyltransferase activity, mannosyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ALG1 itself. We selected most functions ALG1 had, and list some proteins which have the same functions with ALG1. You can find most of the proteins on our site.
Function | Related Protein |
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chitobiosyldiphosphodolichol beta-mannosyltransferase activity | |
mannosyltransferase activity | PIGB;PIGV;DPY19L1L;GTDC2;B3GNTL1;DPY19L1;ALG9;DPY19L3;DPY19L4 |
ALG1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ALG1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ALG1.
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- Q&As
- Reviews
Q&As (19)
Ask a questionALG1 testing costs vary by hospital and region and may fluctuate within a range.
ALG1 testing does not require special preparation before it is performed, but if a blood sample needs to be collected, the blood collection process needs to be completed under the guidance of a doctor.
ALG1 deficiency is a genetic disorder, so it may affect members of its family.
ALG1 defects are usually caused by mutations, loss or deletion of genes, which in turn affect the metabolism of protein glycosylation.
ALG1 defects may affect fertility and can cause problems such as genetic disorders.
ALG1 is an important gene involved in protein glycosylation in human body, and plays an important role in maintaining the normal function of human body.
Testing is not a routine procedure and is usually done on the advice of a doctor.
Detection can be interfered with by a number of factors, such as clinical symptoms, age, gender, diet, and so on.
Deficiency has a familial genetic risk, and the risk of developing the disease depends on the family genetic history.
ALG1 test results need to be interpreted and analyzed by a professional.
ALG1 testing is performed by a professional clinical geneticist and laboratory technician.
ALG1 detection is mainly used to detect CDG1K and other related diseases.
ALG1 deficiency is a genetic disorder that can be passed on to future generations through genes.
This protein can be tested in the form of blood or oral swabs.
Testing does not require fasting.
Deficiency of ALG1 may cause a rare glycoprotein Disorder called Glycosylation 1k syndrome (CDG1K), which includes mental retardation, motor degeneration, and muscle relaxation.
Deficiency may cause mental retardation, motor function degradation, fluid on the head, eye problems and other symptoms.
Deficiency can be treated with targeted treatment for its clinical manifestations, such as symptom relief, rehabilitation, etc.
Testing may help in the early detection of related diseases, so that targeted prevention and treatment measures can be taken, but often cannot prevent all related diseases.
Customer Reviews (4)
Write a reviewThe protein specificity is high and the misdiagnosis rate is low.
The most suitable detection method is ELISA.
High sensitivity in diagnosis.
Detection limit is low, low content can also be successfully detected。
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