ALG14
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Official Full Name
ALG14 asparagine-linked glycosylation 14 homolog (S. cerevisiae) [ Homo sapiens ]
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Overview
Asparagine (N)-glycosylation is an essential modification that regulates protein folding and stability. ALG13 and ALG14 (MIM 612866) constitute the UDP-GlcNAc transferase, which catalyzes a key step in endoplasmic reticulum N-linked glycosylation (Averbeck et al., 2007 [PubMed 17686769]). -
Synonyms
asparagine-linked glycosylation 14 homolog (S. cerevisiae); MGC19780; asparagine-linked glycosylation 14 homolog (yeast); UDP-N-acetylglucosamine transferase subunit ALG14 homolog; ALG14;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rat
- Zebrafish
- E.coli
- HEK293
- Mammalian Cell
- His
- His (Fc)
- Avi
- N/A
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
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Human | ALG14-9574H | Recombinant Human ALG14, His-tagged | E.coli | His | 27-216a.a. | |
Human | ALG14-8907HCL | Recombinant Human ALG14 293 Cell Lysate | HEK293 | N/A |
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Mouse | ALG14-1545M | Recombinant Mouse ALG14 Protein | Mammalian Cell | His |
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Mouse | ALG14-465M | Recombinant Mouse ALG14 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi |
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Mouse | ALG14-465M-B | Recombinant Mouse ALG14 Protein Pre-coupled Magnetic Beads | HEK293 |
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Rat | ALG14-629R | Recombinant Rat ALG14 Protein | Mammalian Cell | His |
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Rat | ALG14-285R | Recombinant Rat ALG14 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi |
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Rat | ALG14-285R-B | Recombinant Rat ALG14 Protein Pre-coupled Magnetic Beads | HEK293 |
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Zebrafish | ALG14-1598Z | Recombinant Zebrafish ALG14 | Mammalian Cell | His |
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- Involved Pathway
- Protein Function
- Interacting Protein
- ALG14 Related Articles
ALG14 involved in several pathways and played different roles in them. We selected most pathways ALG14 participated on our site, such as Asparagine N-linked glycosylation, Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with ALG14 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Asparagine N-linked glycosylation | TRAPPC6A;SEC23A;ALG10B;STT3A;TRAPPC6BL;TRAPPC3;NAPB;OS9;MAGT1 |
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein | ST6GALNAC2;NEU4;SLC35A1;ZNF408;MPDU1B;ST3GAL3A;ALG10B;ALG2;GNE |
Metabolic pathways | GULO;GLS;ATP6V0E1;PIGK;NDUFB3;GALCB;UPP2;AKR1B7;AMY1B |
Metabolism of proteins | ALG14;ADAMTS18;PPP6R1;HSCB;GPR119;TRAPPC6A;CPE;PCSK1;NSMCE4A |
N-Glycan biosynthesis | FUT8A;ST6GAL2;MGAT1;STT3B;ST6GAL1;MGAT5B;ALG8;ALG11;DPM1 |
Post-translational protein modification | GALNT6;RING1;MIA3;SCMH1;PHC2;EIF5A2;TRAPPC1;THSD1;ALG14 |
ALG14 has several biochemical functions, for example, contributes_to N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity, protein anchor. Some of the functions are cooperated with other proteins, some of the functions could acted by ALG14 itself. We selected most functions ALG14 had, and list some proteins which have the same functions with ALG14. You can find most of the proteins on our site.
Function | Related Protein |
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contributes_to N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity | |
protein anchor | SUN3;SUN5;RAPSN;AKAP6;NUP153;CIB1;ALG14;SUN1;SLC4A1 |
ALG14 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ALG14 here. Most of them are supplied by our site. Hope this information will be useful for your research of ALG14.
- Q&As
- Reviews
Q&As (18)
Ask a questionOverexpression or knockout of ALG14 may negatively affect cellular glycosylation and the stability of ER and Golgi bodies, but the specific effects need to be further explored.
The relationship between ALG14 and neurological diseases needs further study, but it is known to be associated with diseases such as intellectual deficiency and idiopathic epilepsy.
ALG14 mutations have been shown to be associated with a variety of neurological disorders such as intellectual impairment and idiopathic epilepsy.
ALG14 is involved in metabolic pathways such as glycosylation and glucose metabolism, and has important biological functions.
ALG14 is mainly distributed in the endoplasmic reticulum (ER) and the Golgi apparatus.
ALG14 is involved in several biological processes including protein glycosylation, ER and Golgi body sugar metabolism.
ALG14, as a member of UDP-glucose-glycosyltransferase, is involved in the synthesis and modification of sugar chains during glycosylation, and plays an important role in the glycosylation and modification of post-translational mitochondrial proteins and plasma membrane proteins.
This protein can selectively catalyze the specific chemical structure of sugar chains, thereby affecting the biological properties and function of proteins.
This is an important UDP-glucose-glycosyltransferase. It plays a very important role in protein glycosylation and cell growth.
As a member of the UDP-glucose-glycosyltransferase family, ALG14 is functionally similar to ALG13, ALG1 and other family members.
Although the function of ALG14 in the non-cellular autophagy pathway has not been clearly studied, there are indications that it may be involved in the TCA cycle and gluconeogenic pathway.
This protein can influence the specific structure, length and branching of sugar chains through selective glycosylation reactions.
ALG14 interacts with glycosylation enzymes such as ALG13, ALG1 and mannosyltransferase to jointly regulate the glycosylation process of proteins.
ALG14 may be involved in mitochondrial glucose metabolism, although more research is needed to investigate the specific mechanism.
There is currently no direct evidence that ALG14 is associated with the onset and development of diabetes, but glycosylation plays a key role in metabolism and disease development, so it may be involved in diabetes.
No studies have shown that ALG14 is directly related to the occurrence of neurodegenerative diseases, but glycosylation plays a crucial role in the development and function of the nervous system, so it may be related to neurodegenerative diseases.
The regulates the expression of glycosylase and the balance of glycosylation reaction by interacting with other glycosylated enzymes such as ALG13 and ALG1.
Several inhibitors have been developed to target ALG14, including inhibiting its glycosylation activity and regulating its interactions with other glycosylated enzymes.
Customer Reviews (3)
Write a reviewCatalyze the hydrolysis of clindamycin phosphate to clindamycin, and make it play an antibiotic role.
ALG14 had high purity and no obvious impurities.
Can be detected by AGAR electrophoresis method, it is convenient.
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