ALPPL2
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Official Full Name
alkaline phosphatase, placental-like 2
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Overview
There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The product of this gene is a membrane bound glycosylated enzyme, localized to testis, thymus and certain germ cell tumors, that is closely related to both the placental and intestinal forms of alkaline phosphatase. -
Synonyms
ALPPL2; alkaline phosphatase, placental-like 2; alkaline phosphatase, placental-like; ALP-1; Nagao isozyme; germ cell alkaline phosphatase; alkaline phosphatase Nagao isozyme; placental-like alkaline phosphatase; testicular and thymus alkaline phosphatase;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- E.coli
- HEK293
- In Vitro Cell Free System
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- Myc|DDK
- N/A
- N
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
---|---|---|---|---|---|---|
Human | ALPPL2-496H | Recombinant Human ALPPL2 Protein, GST-tagged | Wheat Germ | GST | ||
Human | ALPPL2-3272H | Recombinant Human ALPPL2, His-tagged | E.coli | His | 532 | |
Human | ALPPL2-65HCL | Recombinant Human ALPPL2 cell lysate | N/A | |||
Human | ALPPL2-1488HF | Recombinant Full Length Human ALPPL2 Protein, GST-tagged | In Vitro Cell Free System | GST | 532 amino acids | |
Human | ALPPL2-2862H | Active Recombinant Human ALPPL2 protein, His-Avi-tagged, Biotinylated | HEK293 | His-Avi | Ile 20-Asp 503 | |
Human | ALPPL2-1993H | Recombinant Human ALPPL2 Protein, MYC/DDK-tagged | HEK293 | Myc/DDK | ||
Mouse | ALPPL2-1576M | Recombinant Mouse ALPPL2 protein, His-tagged | HEK293 | His | Val 19 - Ser 502 | |
Mouse | ALPPL2-490M | Recombinant Mouse ALPPL2 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Mouse | Alppl2-126M | Recombinant Mouse Alppl2 Protein, His&GST-tagged | E.coli | N-His&GST | Val19-Ser502 | |
Mouse | ALPPL2-490M-B | Recombinant Mouse ALPPL2 Protein Pre-coupled Magnetic Beads | HEK293 |
- Involved Pathway
- Protein Function
- Interacting Protein
ALPPL2 involved in several pathways and played different roles in them. We selected most pathways ALPPL2 participated on our site, such as Folate biosynthesis, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with ALPPL2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Folate biosynthesis | DHFRL1;SPRA;ALPI;ALPL;ALPI.2;QDPR;GCH2;QDPRB2;PTS |
Metabolic pathways | ALDH3B1;POLR2GL;ATP5C1;ATP5E;ALG10;B3GALT2;MAT2AB;UGT1A7;MTMR7 |
ALPPL2 has several biochemical functions, for example, alkaline phosphatase activity, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ALPPL2 itself. We selected most functions ALPPL2 had, and list some proteins which have the same functions with ALPPL2. You can find most of the proteins on our site.
Function | Related Protein |
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alkaline phosphatase activity | ALPI;ALPP;ALPL;ALPPL2;ALP3;ALPI.1 |
metal ion binding | PHF23B;LONRF1L;MARCH9;ZNF423;RBM22;RPS27.2;TRIM35-29;ROCK1;XGB |
ALPPL2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ALPPL2 here. Most of them are supplied by our site. Hope this information will be useful for your research of ALPPL2.
Erh; Cep76
- Q&As
- Reviews
Q&As (10)
Ask a questionManipulating ALPPL2 activity and function holds promise for modulating cellular processes and disease outcomes, potentially offering new therapeutic avenues for metabolic disorders, liver diseases, and lipid-related conditions.
Dysregulation or deficiency of ALPPL2 has been associated with metabolic disorders, liver diseases, and dyslipidemia, highlighting its contribution to the pathogenesis of these conditions.
ALPPL2 may serve as a potential diagnostic biomarker for specific diseases, providing insights into disease progression and therapeutic response, and it could be explored as a therapeutic target for developing interventions in certain pathological contexts.
ALPPL2 participates in cellular processes such as lipid metabolism, cell signaling, and membrane dynamics, and it interacts with other proteins and molecules involved in these processes.
ALPPL2 expression and activity are influenced by various physiological and pathological stimuli, including hormonal regulation, nutrient availability, and disease conditions.
ALPPL2 exhibits a specific expression pattern, with higher levels in certain tissues such as the liver, kidney, and intestine, and it is primarily localized to the plasma membrane or specific subcellular compartments.
ALPPL2 regulates downstream signaling pathways and molecular targets involved in lipid metabolism, cell proliferation, and cell survival, influencing cellular processes such as lipid signaling, membrane trafficking, and cell growth.
ALPPL2 is involved in the metabolism and turnover of its substrates, including lipid molecules and membrane components, playing important roles in cellular lipid homeostasis and membrane remodeling.
ALPPL2 expression is controlled by transcriptional regulators, signaling pathways, and epigenetic modifications that respond to specific cellular signals and environmental cues.
ALPPL2 activity can be modulated by specific factors, such as hormones or lipid-binding proteins, and inhibitors that target its catalytic site or affect its membrane association, leading to altered enzymatic activity and cellular functions.
Customer Reviews (3)
Write a reviewVersatile applications in multiple assay formats.
Easy-to-use assay kit with clear protocols.
Fast and efficient protein purification.
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